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Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination - Nov 2011
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[Time: 3 Hours] [Max. Marks: 100]
PREFORMULATION AND PRODUCTION MANAGEMENT
(RS 2 & RS 3)
Q.P. CODE: 9282
Your answers should be specific to the questions asked.
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Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- What is the objective of preformulation studies? How are crystal properties studied? Explain the ß-cyclodextrin drug dispersion systems.
- Explain the concepts of TQM. How are validation systems evolved and implemented in a tablet manufacturing unit?
- a) Write briefly about effect of particle size, moisture content and lubrication on strength of tablets
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b) Explain the concepts of scale up and pilot plant with particular reference to tablets.
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Mechanical hazards and fire accidents
- Drug exipient interaction
- Centralized and decentralized purchasing
- Types of material handling systems
- Inventory evaluation
- Solubilisation
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SHORT NOTES 2 X 5 = 10 Marks
- Energy involved in compression consolidation in high loads for tablets.
- TRIPS and TRIMS
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*****
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