Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - Nov 2011
[Time: 3 Hours] [Max. Marks: 100]
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PHARMACEUTICAL BIOTECHNOLOGY - I
(RS 2 & RS 3)
Q.P. CODE: 9312
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
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LONG ESSAY (Answer any FOUR) 4 X 25 = 100 Marks
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- Define taxonomy, species, strain and binomial system. Discuss numerical taxonomy
- Differentiate anabolism from catabolism. Explain glycolysis, with respect to carbohydrate metabolism
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- Enlist any four important characteristics of viruses and discuss the replication process of animal viruses containing RNA
- Describe the nutritional requirements of bacteria with specific examples and explain the mechanisms of substrate entry into the cell
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- Define Mutation and enlist various mutagens with specific examples. Discuss various strain improvement techniques
- Differentiate primary screening from secondary screening. Discuss the detection methods and briefly outline the assay methods of fermentation products
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- Discuss the production of citric acid by fermentation and mention its uses
- Explain the salient features of mixed fermentation and discuss animal cell culture techniques
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- Discuss the production of penicillin by fermentation process
- What are the advantages of microbial transformations over other methods? Discuss microbial transformations of alkaloids and terpenes
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Write short notes on:
- Growth of microorganisms and general considerations
- Aerobic respiration and anaerobic respiration
- Ergot alkaloids
- Role of plasmids in antibiotic resistance
- Patents
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