Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - May 2011
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[Time: 3 Hours] [Max. Marks: 100]
MEDICINAL CHEMISTRY I (DRUG DESIGN)
PAPER III
(RS 2 & RS 3)
Q.P. CODE: 9233
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- a) Explain the historical development of QSAR.
b) Explain the design of stereo and geometric isomers. - What is protein engineering and site directed mutagenesis? Give it's development as therapeutic agent.
- a) Explain the role of proton pump inhibitors in therapeutic use.
b) Explain the applications of Hansch analysis.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain the role of Bioisosteric replacements and rigid analogs in drug design.
- Explain various practical aspects of microbial transformation.
- Give various approaches to rational drug design of non-covalently binding enzyme inhibitors.
- Discuss about immunosuppressive and immunostimulative agents.
- Write about the development and uses of pro drug design.
- Write about the theoretical aspects of drug action.
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SHORT NOTES 2 X 5 = 10 Marks
- Add a note on recombinant DNA technology
- Write a note on the importance of ACE inhibitors.
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