Download RGUHS (Rajiv Gandhi University of Health Sciences) M Pharma (Master of Pharmacy) First Year (1st Year) 2011 May 9243 Pharmacological Screening Methods And Clinical Evaluation Paper III Question Paper.
Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination ? May 2011
[Time: 3 Hours] [Max. Marks: 100]
PHARMACOLOGICAL SCREENING METHODS
AND CLINICAL EVALUATION
PAPER III
(RS 2 & RS 3)
Q.P. CODE: 9243
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
1. a) Explain the various methods of Bio ? assay. Give its merits & demerits
b) Discuss the bioassay of Posterior pituitary extract.
2. a) How will you experimentally induce diabetes in laboratory animals
b) Explain the various methods used to screen antidiabetic drugs
3. Arrive at the various pharmacokinetic parameters following one compartment model extra
vascular drug administration
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
4. Volume of distribution & its importance
5. List various screening models for anti ? arrhythmic activity. Explain an in ? vitro & an in ? vivo
method
6. Kinetics of drug absorption
7. Explain the different patch clamp techniques
8. General characteristics of Lab Mice
9. List the different screening models for anti-inflammatory drugs. Explain Randal selato model
SHORT NOTES 2 X 5 = 10 Marks
10. Institutional animal ethical committee (IAEC)
11. Role of genetics in variability of drug metabolism
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This post was last modified on 20 December 2019