RGUHS M.Pharm 1st Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination – May 2011
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| [Time: 3 Hours] | [Max. Marks: 100] |
PHARMACOLOGICAL SCREENING METHODS AND CLINICAL EVALUATION
PAPER III
(RS 2 & RS 3)
Q.P. CODE: 9243
Your answers should be specific to the questions asked.
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Draw neat labeled diagrams wherever necessary. Answer all questions
| LONG ESSAY (Answer any TWO) | 2 X 20 = 40 Marks |
- a) Explain the various methods of Bio - assay. Give its merits & demerits
b) Discuss the bioassay of Posterior pituitary extract. - a) How will you experimentally induce diabetes in laboratory animals
b) Explain the various methods used to screen antidiabetic drugs - Arrive at the various pharmacokinetic parameters following one compartment model extra vascular drug administration
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| SHORT ESSAY (Answer any FIVE) | 5 X 10 = 50 Marks |
- Volume of distribution & its importance
- List various screening models for anti-arrhythmic activity. Explain an in-vitro & an in- vivo method
- Kinetics of drug absorption
- Explain the different patch clamp techniques
- General characteristics of Lab Mice
- List the different screening models for anti-inflammatory drugs. Explain Randal selato model
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| SHORT NOTES | 2 X 5 = 10 Marks |
- Institutional animal ethical committee (IAEC)
- Role of genetics in variability of drug metabolism
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