Rajahdaandhi University of Health Sciences
First Year M. Pharm Degree Examination - Oct/Nov 2014
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[Time: 3 Hours] [Max. Marks: 100]
Advanced Pharmacology and Toxicology
(Revised Scheme 4)
Q.P. CODE: 9349
Your answers should be specific to the questions asked.
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Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Enumerate various cell surface receptor families and explain the transduction pathway involved in ion channel receptors and tyrosine kinase linked receptors.
- Explain pathophysiology and pharmacotherapy of Parkinson's and Alzheimer's disease. (10+10)
- What is mutagenicity? Enlist and explain various mutagenicity studies. (2+18)
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Explain the pathogenesis of cardiac arrhythmias and write the pharmacology of any one drug used for treatment of arrhythmias. (4+6)
- Explain the role of neurotransmitters as signaling molecules with examples.
- Explain biosynthesis, physiological roles of 5-hydroxy tryptamine. (4+6)
- Explain the principles and methods involved in male reproductive toxicity studies. (5+5)
- Write a note on pharmacotherapy and critical analysis of rational use of drugs for COPD. (7+3)
- Explain cAMP as intracellular signal transduction secondary messenger.
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SHORT NOTES 2 X 5 = 10 Marks
- Explain the pharmacotherapy of congestive heart failure.
- Explain the generation and actions of cytokines.
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