Download RGUHS M.Pharmacy First Year 2015 November 9351 Molecular Biology RS 4 Question Paper

First Rajahdaandhi University of Health Sciences

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First Year M. Pharm Degree Examination - NOVEMBER 2015

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[Time: 3 Hours] Q.P. CODE: 9351 [Max. Marks: 100]

Molecular Biology (Revised Scheme 4)

Your answers should be specific to the questions asked.

Draw neat, labeled diagrams wherever necessary.

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks

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1. Explain various phases of cell cycle with a diagrammatic representation. Enumerate the various checkpoints in cell cycles. Add a note on regulators and modifiers of cell cycle. (10+4+6)

2. What is gene expression? Explain the process of gene expression in eukaryotic cell. Enumerate the genetic elements that control the gene expression. (2+12+6)

3. List various cell signaling and communication pathways between cells. What are biosensors? Explain the construction and applications of biosensors. (4+2+8+6)

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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks

4. a) Explain the applications of rDNA technology.

5. a) Explain salient feature of various vectors used in gene therapy.

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6. Explain the events of apoptosis. Add a note on regulators of apoptosis. (6+4)

7. Write a note on plasma membrane transport proteins and their inhibitors. (5+5)

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8. What is gene mapping? Name and explain various methods of gene mapping. (2+2+6)

9. Write the principles and applications of radio-ligand binding assay. (5+5)

10. b) Explain the principle of antisense technology.

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11. With a neat-labeled diagram, explain the structure and functions of cell membrane and mitochondria. (5+5)

SHORT NOTES 2 X 5 = 10 Marks

10. Explain in brief the concept of human genome project.

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11. Write a note on pharmacological applications on animal tissue culture.

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