Download RGUHS Pharm-D 4th Semester 2016 Nov-Dec 2871 Biopharmaceutics And Pharmacokinetics Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharm.D (Doctor of Pharmacy) 4th Semester 2016 Nov-Dec 2871 Biopharmaceutics And Pharmacokinetics Question Paper.

Rajiv Gandhi University of Health Sciences, Karnataka
IV Year Pharm-D / I Year Pharm-D (Post Baccalaureate) Degree Examination ? NOV
2016
Time: Three Hours Max. Marks: 70 Marks
BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. CODE: 2871
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (Answer any two) 2 x 10 = 20 Marks
1. Define absorption. What are the various physicochemical factors affecting rate of
absorption?
2. What is compartment modeling? State the assumptions of Two Compartment Model and
explain Two Compartment Model with administration through i.v infusion.
3. What are non-linear pharmacokinetics? Discuss the various factors causing non-linearity.

SHORT ESSAYS (Answer any six) 6 x 5 = 30 Marks
4. Explain Statistical Moment theory.
5. What is gastric emptying? Discuss the factors affecting gastric emptying of drugs.
6. Explain the influence of pharmaceutical ingredients on drug absorption.
7. What is renal clearance? Discuss any three factors affecting renal clearance.
8. Loading and maintenance dose
9. Discuss various methods to improve bioavailability of Class II drugs.
10. What is protein binding? Discuss the significance of protein binding with examples.
11. Influence of physiological barriers in drug distribution

SHORT ANSWERS 10 x 2 = 20 Marks
12. Fick?s first law of diffusion
13. Buffered Aspirin tablets are more suitable than sodium salt forms of the drug. Why?
14. Unlike glomerular filtration, active secretion of drug is unaffected by protein binding. Give
reasons.
15. Define Pharmacokinetics. Mention its application in drug discovery.
16. Calculate the amount of drug in the body when the plasma concentration is 10ng/ml and
volume of distribution of drug is 300lts.
17. Absorption window ? mention its significance.
18. Demerits of Wagner Nelson method in calculating Ka
19. Define Pharmaceutical and biological equivalence.
20. What is Zero Order reaction? Give example.
21.
What is AUC? Give the equation to calculate ?
?
?
AUC.
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