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Rajiv Gandhi University of Health Sciences, Karnataka
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IV Year Pharma-D (Post Baccalaureate) Examination - Mar 2013
Time: Three Hours
Max. Marks: 70 Marks
BIOPHARMACEUTICS & PHARMACOKINETICS
Q.P. CODE: 2871
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Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- Explain various approaches to improve the dissolution of poorly soluble drugs
- What are the advantages of Non compartment models over compartment modeling? Discuss in brief the statistical moment theory, mean residence time and physiologic models
- Define the terms Dosage Regimen, loading dose and maintenance dose. What are the various way of monitoring drug therapy in individual patient?
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Discuss absorption of drugs by active transport
- State the pH partition hypothesis briefly. On what assumptions this statement is based
- Why are first-order processes said to follow linear kinetics? Explain
- The parameter K? has different meanings for one-and two-compartment models - Explain
- What are the merits and demerits of Wagner-Nelson method in computing Ka?
- Discuss Glucuronidation in Phase II reactions
- Discuss the causes of Nonlinearity in pharmacokinetics
- What is the criteria for obtaining valid urinary excretion data?
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SHORT ANSWERS 10 x 2 = 20 Marks
- It is better to express AUC (Area Under the Curve) as mg.hr/kg body weight. Why?
- What are the 2 major sources of variability in drug response?
- What is flip-flop phenomenon and when it is observed?
- What are drug metabolizing organs?
- Why is bio equivalency studies always performed in healthy human volunteers?
- Define zero order process. Give the equation for zero order half life
- How Crohn's disease affects drug absorption?
- In compartment modeling what does the term 'open' mean
- Define minimum effective concentration and maximum safe concentration
- Define enzyme induction and auto-induction
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