Download JNTUH Pharm D 3rd Year PH3 Medicinal Chemistry Question Paper

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Answer any five questions
All questions carry equal marks
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1.a) What is Hansch analysis? Write its merits.

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b) What is CADD? Write its importance. [7+7]

2.a) What are anti-tubercular agents? Classify them with examples. Add a note on the
regimens currently employed in theraphy.
b) Outline the synthesis and uses of Isoniazid. [7+7]

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3.a) Write the mechanism of action of sulphonamides.
b) Outline the synthesis of sulphamethaxozole and pyrimethamine. [7+7]

4.a) What are antibiotics? Classify them with examples and add a note on ?-lactam

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antibiotics.
b) Outline the synthesis of mercaptopurine and busulphan. [7+7]

5.a) What is essential hypertension? Classify the anti-hypertensive agents with their
mode of action.

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b) What do you know of anti-hyperlipidemic agents? [7+7]

6.a) Outline the synthesis of metformin and glibenclamide.
b) What do you know of thyroid drugs? [7+7]

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7.a) What are diureties? Classify them with examples and write the mode of action of
acetazolamide and hydrochlorthiazide?
b) Write the SAR of thiazide diureties. [7+7]

8.a) Write the synthesis of iopanoic acid and diatrizoate sodium.

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b) What do you know of adrenocorticoids? [7+7]


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