--- Content provided by FirstRanker.com ---Answer any five questions
All questions carry equal marks
- - -
1.a) Define Biopharmaceutics. Explain the mechanism of drug absorption by passive
b) Explain the factors influencing drug absorption from GIT. [6+8]
2.a) Describe the compartment model and physiologic pharmacokinetic model.
b) Write short notes on plasma drug concentration-time curve. [8+6]
3.a) Derive an equation for one compartment open model intravenous Bolus injection.
b) Write short notes on clearance. [10+4]
4. Write short notes on:
b) Estimation of excretion rate constant by Sigma-Minus method. [8+6]
5.a) Write short notes on drug accumulation.
b) Explain the plasma versus time profile for repetitive IV Injection using one compartment
6.a) Discuss in detail the potential causes for Nonlinear Pharmacokinetics.
b) Derive Michaelis-Menton equation. [6+8]
b) Derive an equation for determination of MRT from plasma concentration data of an
IV bolus administration following elimination by first order process. [6+8]
8.a) Give the Table for Bioavailability study protocol.
c) Write a note on Cross over design. [3+6+5]
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All questions carry equal marks
- - -
1.a) Define Biopharmaceutics. Explain the mechanism of drug absorption by passive
--- Content provided by FirstRanker.com ---
diffusion and active transport.b) Explain the factors influencing drug absorption from GIT. [6+8]
2.a) Describe the compartment model and physiologic pharmacokinetic model.
b) Write short notes on plasma drug concentration-time curve. [8+6]
--- Content provided by FirstRanker.com ---
3.a) Derive an equation for one compartment open model intravenous Bolus injection.
b) Write short notes on clearance. [10+4]
4. Write short notes on:
--- Content provided by FirstRanker.com ---
a) Determination of absorption rate constant by Wagner-Nelson method.b) Estimation of excretion rate constant by Sigma-Minus method. [8+6]
5.a) Write short notes on drug accumulation.
b) Explain the plasma versus time profile for repetitive IV Injection using one compartment
--- Content provided by FirstRanker.com ---
open model. [4+10]6.a) Discuss in detail the potential causes for Nonlinear Pharmacokinetics.
b) Derive Michaelis-Menton equation. [6+8]
--- Content provided by FirstRanker.com ---
7.a) Write short notes on Statistical Moment Theory.b) Derive an equation for determination of MRT from plasma concentration data of an
IV bolus administration following elimination by first order process. [6+8]
8.a) Give the Table for Bioavailability study protocol.
--- Content provided by FirstRanker.com ---
b) Explain the method of assessment of Bioavailability from plasma data.c) Write a note on Cross over design. [3+6+5]
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