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Rajiv Gandhi University of Health Sciences, Karnataka
IIT Year B.Pharm Degree Examination — 04-Jan-2020
Time: Three Hours Max. Marks: 70 Marks
MEDICINAL CHEMISTRY -1
(Revised Scheme 3)
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Q.P. CODE: 2611
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- What are analgesics? Classify analgesics with examples. Outline the synthesis of piroxicam and Oxyphenbutazone.
- Illustrate with examples adrenergic blocking agents. Write the synthesis of Phentolamine & Propranolol.
- Discuss how the following physicochemical properties influence the biological activity a) Solubility b) Protein binding c) Redox potential d) Surface activity.
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SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Outline the synthesis and uses of Glutethimide and Chloralhydrate.
- Outline the synthesis and uses of Clonazepam and Phenobarbitone.
- Write the structure and uses of the following compounds? a) Ranitidine b) Omeprazole c) Practolol.
- Write the structure and uses of any five cholinergic blocking agents.
- What are general anaesthetics? Give its classification. Write a note on dissociative anaesthetics
- Write the SAR of Barbiturates as Sedatives & Hypnotics.
- What are Eicosanoids? Give some examples.
- Write a note on reversible cholinesterase inhibitors.
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SHORT ANSWERS 10 x 2 = 20 Marks
- Outline the synthesis of Diphenhydramine HCl.
- What is Glycine conjugation reaction in drug metabolism & give one example?
- Write the structure and use of Carbamazepine and Methohexital Sodium.
- Outline the synthesis of Chlorphensin.
- Drugs used in spasticity.
- Outline the synthesis of Naphazoline.
- Write in brief about cholinergic receptors.
- Structure and uses of Cyclopentamine and Meprobomate.
- Write the structure of any two Narcotic Antagonists.
- Synthesis of Procaine.
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