Download RGUHS B.Pharm 2020 3rd Year 2611 Medicinal Chemistry I Revised Scheme 3 Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Bachelor of Pharmacy (B.Pharm) 2020 3rd Year 2611 Medicinal Chemistry I Revised Scheme 3 Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
III Year B.Pharm Degree Examination ? 04-Jan-2020
Time: Three Hours





Max. Marks: 70 Marks
MEDICINAL CHEMISTRY - I
(Revised Scheme 3)
Q.P. CODE: 2611
Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAYS (Answer any Two)
2 x 10 = 20 Marks
1.
What are analgesics? Classify analgesics with examples. Outline the synthesis of piroxicam and
Oxyphenbutazone.
2.
Illustrate with examples adrenergic blocking agents. Write the synthesis of Phentolamine &
Propranolol.
3.
Discuss how the following physicochemical properties influence the biological activity
a) Solubility b) Protein binding c) Redox potential d) Surface activity.
SHORT ESSAYS (Answer any Six)
6 x 5 = 30 Marks
4.
Outline the synthesis and uses of Glutethimide and Chloralhydrate.
5.
Outline the synthesis and uses of Clonazepam and Phenobarbitone.
6.
Write the structure and uses of the following compounds?
a) Ranitidine b) Omeprazole c) Practolol.
7.
Write the structure and uses of any five cholinergic blocking agents.
8.
What are general anaesthetics? Give its classification. Write a note on dissociative anaesthetics
9.
Write the SAR of Barbiturates as Sedatives & Hypnotics.
10. What are Eicosanoids? Give some examples.
11. Write a note on reversible cholinesterase inhibitors.
SHORT ANSWERS
10 x 2 = 20 Marks
12. Outline the synthesis of Diphenhydramine HCl.
13. What is Glycine conjugation reaction in drug metabolism & give one example?
14. Write the structure and use of Carbamazepine and Methohexital Sodium.
15. Outline the synthesis of Chlorphensin.
16. Drugs used in spasticity.
17. Outline the synthesis of Naphazoline.
18. Write in brief about cholinergic receptors.
19. Structure and uses of Cyclopentamine and Meprobomate.
20. Write the structure of any two Narcotic Antagonists.
21. Synthesis of Procaine.
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