Rajiv Gandhi University of Health Sciences, Karnataka
III Year B. Pharm Degree Examination — 04-Jan-2020
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Time: Three Hours Max. Marks: 70 Marks
MEDICINAL CHEMISTRY - I
(RS - 4)
Q.P. CODE: 2635
Your answers should be specific to the questions asked
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Draw neat labeled diagrams wherever necessary.
LONG ESSAYS (Answer any Two) 2 x 10 = 20 Marks
- What are conjugation reactions? Explain the role of these reactions in drug metabolism with any two examples.
- Explain the SAR of phenothiazines. Outline the synthesis of haloperidol and chlorpromazine.
- a) Explain role of Cytochrome P-450 in biotransformation.
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b) Explain the SAR of barbiturates.
SHORT ESSAYS (Answer any Six) 6 x 5 = 30 Marks
- Outline the biosynthesis and metabolism of adrenergic neurotransmitters
- Give the synthesis of dicyclomine and tropicamide
- Classify local anaesthetic agents and explain their mechanism of action
- What are H2 receptor antagonists? Explain their mechanism of action and mention their medicinal uses.
- Write the synthesis and uses of methadone and dextromethorphan
- Explain the interrelationship between caffeine, theophylline and theobromine.
- Write a note on B-adrenergic blocking agents.
- Write a note on cholinesterase inhibitors.
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SHORT ANSWERS 10 x 2 = 20 Marks
- What is phase I biotransformation
- Give the structure and chemical name of phenobarbitone
- Give the structure and uses of baclofen and buspirone
- Give the structure and medicinal uses of methyl dopa and naphazoline
- Outline the synthesis of neostigmine
- Write the structure and uses of any two neuromuscular blocking agents
- Write the structure and uses of tripelenamine and pheniramine
- What are anti-tussive agents? Give an example with structure
- Give the structure and chemical name of ibuprofen
- Write the structure and medicinal uses of any two prostaglandins
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This download link is referred from the post: RGUHS B.Pharm 4th Year 2020 Previous Question Papers - Rajiv Gandhi University of Health Sciences
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