Download RGUHS B.Pharm 2020 4th Sem 5014 Medicinal Chemistry I Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Bachelor of Pharmacy (B.Pharm) 2020 4th Sem 5014 Medicinal Chemistry I Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
Fourth Semester B. Pharm Degree Examination ? 07-Jan-2020
Time: Three Hours






Max. Marks: 75 Marks
MEDICINAL CHEMISTRY - I
Q.P. CODE: 5014
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAYS (Answer any Two)
2 x 10 = 20 Marks
1.
Define and classify sedatives and hypnotic giving examples with one structure from each
class. Discuss the SAR of benzodiazepines.
2.
Define and classify general anesthetic with examples. Explain their mode of action. Write
the synthesis of methahexital sodium.
3.
a) What are adrenergic blockers? Classify alpha and beta adrenergic blockers with one
structure from each class.
b) Write the synthesis and uses of Tolazoline and Propronolol.
SHORT ESSAYS (Answer any Seven)
7 x 5 = 35 Marks
4.
Define and classify NSAIDS with example. Give the structure of one drug from each class.
5.
Discuss the SAR of phenothiazine analogs used as tranquilizers.
6.
What are direct acting sympathomimetics? Write four structures and their uses. Outline the
synthesis of any one.
7.
Explain the role of hydrogen bonding and protein binding on drug action.
8.
Explain the importance of optical and geometrical isomerism in relation to biological action
of drugs.
9.
What is Phase ? I metabolism? Explain reductive and hydrolytic metabolisms with
examples.
10. Write the mechanism of action of cholinesterase inhibitors. Give two structural examples
each for reversible and irreversible type.
11. Discuss the SAR of cholinergic agonists.
12. Give an account on solanaceous alkaloids with structural examples. Write the synthesis of
Ipratropium bromide.
SHORT ANSWERS (Answer All)
10 x 2 = 20 Marks
13. Write a note on nicotinic receptors.
14. Write the structure and uses of Pilocorpine and Pyridostigmine.
15. Write the synthesis of Procyclidine hydrochloride.
16. What are Narcotic antagonists? Give two examples with structure.
17. Write a note on the role of ionization on drug action.
18. Explain amino acid conjugation in phase-II metabolism.
19. Write the structure and uses of Atenolol and Metaprolol.
20. Write a note on mixed acting sympathomimetics.
21. Write the structure and uses of Dicyclomine and Clodinium.
22. Write the structure and uses of Haloperidol and Phenytoin.
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