IV Year B.Pharm Degree Examination
Time: 3 Hours [Max. marks : 70]
Medicinal Chemistry II
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(Revised Scheme - 3)
QP Code: 2619
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary.
LONG ESSAY (Answer any two) 2 X 10 = 20 Marks
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- Classify diuretics with examples. Give the mechanism of action of loop diuretics. Write the synthesis of ethacrynic acid and furosemide.
- Classify antimalarials with example. Give their mechanism of action. Write synthesis of trimethoprim and primaquine.
- Classify local anti infective agents with examples. Explain the synthesis of Furazolidone.
SHORT ESSAY (Answer any six) 6 X 5 = 30 Marks
- Classify antitubercular agents with examples. Write the synthesis of p-aminosalicylic acid and ethambutol.
- Write a note on calcium channel blockers.
- Write the SAR of quinolones.
- Write a note on CADD and combinatorial chemistry.
- Classify antiarrhythmic agents with example. Write the synthesis of warfarin
- Write a note on prodrug.
- Classify antihypertensive agents and give the synthesis of chlorpropamide.
- Classify antineoplastic agents. Explain the mechanism of action of Chlorambucil
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SHORT ANSWERS 10 X 2 = 20 Marks
- Write the synthesis of diethyl carbamazine.
- Write the synthesis of thiabendazole.
- Write the structure and use of cycloserine and diloxanide furoate.
- Write the structure and use of thienamycin and chloramphenicol.
- Write the structure and use of macrolide antibiotic.
- Write the synthesis of metronidazole.
- Outline the synthesis of Tolnaftate
- Mention two examples of plant products used as antineoplastic agents.
- Write the structure of any two cephalosporin antibiotics.
- Write the structure and use of L-thyroxine and methimazole.
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