Download RGUHS Pharma D 2020 3rd Year 2865 Medicinal Chemistry Rs And Rs2 Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) Pharma-D (Doctor of Pharmacy) 2020 3rd Year 2865 Medicinal Chemistry Rs And Rs2 Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka
III Year Pharm-D Degree Examination ? 10-Jan-2020
Time: Three Hours





Max. Marks: 70 Marks
MEDICINAL CHEMISTRY (RS & RS2)
Q.P. CODE: 2865
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS (answer any two)
2 x 10 = 20 Marks
1. What are Beta lactum antibiotics? Give the degradation products of penicillins. Outline the
synthesis of Chloramphenicol
2. Classify antihypertensive agents? Write a note on antianginal agents? Give the structure and uses
of any two nitro vasodilators
3. a) What is crystal urea? How to overcome from it.
b) How malaria is caused? Classify antimalarial agents.
SHORT ESSAYS (answer any six)
6 x 5 = 30 Marks
4. Give examples of drugs that act as DNA polymerase inhibitors. Describe their chemistry and
therapeutic uses
5. What are anti TB drugs? Enlist the problems associated with the treatment. Give the structure of
Para amino salicylic acid and INH
6. Add a note on folate reductase inhibitors. Explain the synergistic action of Sulphamethoxazole and
Trimethoprim
7. Write the SAR of i) 8-amino quinolines ii) 4-amino quinolines
8. Give the structure, MOA and therapeutic uses of Chlorambucil
9. Write the briefly about the chemistry and MOA of anticoagulants
10. Give the examples of substituted Imidazoles as antifungal agents? Give the synthesis of
Miconazole.
11. Name any four antiamoebic drugs. Give the synthesis of Metronidazole.
SHORT ANSWERS
10 x 2 = 20 Marks
12. What is CADD? Enlist the applications
13. Write the structure of one prodrug and its active metabolites
14. Name any two calcium channel blockers with their uses
15. Define hyperglycemia? Name any two biguanides used in the treatment of diabetes
16. Give the MOA of biguanides
17. What are antithyroid drugs? Why are they called goitrogens?
18. Structure and uses of Furosemide
19. What are potassium sparing diuretics? Give examples
20. Name any two drugs used for examination of liver function
21. What are steroidal drugs? Name any two steroidal drugs with their uses
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