Download RGUHS M.Pharm 1st Year 2020 7891 Modern Pharmaceutical Analysis Os And Rs Question Paper

First Year M. Pharm Degree Examination

[Time: 3 Hours] [Max. Marks: 100]

MODERN PHARMACEUTICAL ANALYSIS (OS & RS)

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Q.P. CODE : 7891

Your answers should be specific to the questions asked.

Draw neat labeled diagrams wherever necessary. Answer FOUR questions

LONG ESSAYS (ANSWER ANY FOUR) 4 X 25 = 100 Marks

1. a) Explain the general fragmentation rules for organic compounds in mass spectroscopy.

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   b) Write the principles involved in the functioning of quadrupoles and time of flight analyzers.

2. a) What is chemical shift in NMR? Write factors affecting the chemical shift.

   b) Write a brief account on 2D-NMR.

   c) Identify the structure of organic compound using following data:

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   Mol. Wt: C₅H₁₀O

   IR peaks: 2980, 1715, 1375, and 1120 cm^-1

   Mass spectra peak: 86, 71, 58, 43 (base peak) and 27

   ¹³C-NMR peak: 210, 55, 34, 22, 18

   ¹H-NMR spectra (d): 2.4 (2H, triplet), 2.1 (3H, singlet), 1.7 (2H, hextet), 0.9 (3H, triplet)

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3. a) What is Hooke’s law? Write its importance in IR spectroscopy.

   b) What are the difference between dispersive and FT-IR spectrophotometer?

   c) How will you identify the following functional groups in an organic compound?

   OH-, -NH₂, -COOR, -C=C-, -CHO

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4. Write a note on any FIVE only

   1. Atomic absorption spectroscopy
   2. HPTLC
   3. Precolumn derivatisation technique

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   4. Octant rule
   5. Bravais lattices
   6. Test for statistical significance and Student ‘T’ test

5. a) Explain Woodward's rule and its applications in structural elucidation.

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   b) Explain in detail any two methods for simultaneous estimation of multicomponent sample by UV Spectrophotometry.

   c) Explain principle and working of phototube and photomultiplier tube detector in UV-Visible spectrophotometer.

6. a) Write the principles of gas chromatography. Draw a neat labeled diagram of GC instrument and explain any two detectors used.

   b) Explain the principle of super critical fluid chromatography.

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   c) What are theoretical plates? Explain Van-Deemter equation.

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