Download RGUHS M.Pharm 1st Year 2020 7891 Modern Pharmaceutical Analysis Os And Rs Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M.Pharm (Master of Pharmacy) 1st Year (First Semester) 2020 7891 Modern Pharmaceutical Analysis Os And Rs Previous Question Paper

Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination ? 09-Jan-2020
[Time: 3 Hours]
[Max. Marks: 100]
MODERN PHARMACEUTICAL ANALYSIS
(OS & RS)
Q.P. CODE : 7891
Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer FOUR questions
LONG ESSAYS (ANSWER ANY FOUR)
4 X 25 = 100 Marks
1.
a) Explain the general fragmentation rules for organic compounds in mass spectroscopy.
b) Write the principles involved in the functioning of quadrupoles and time of flight analyzers.
2.
a) What is chemical shift in NMR? Write factors affecting the chemical shift.
b) Write a brief account on 2D-NMR.
c) Identify the structure of organic compound using following data:
Mol. Wt: C5H10O
IR peaks: 2980, 1715, 1375, and 1120 cm-1
Mass spectra peak: 86, 71, 58, 43 (base peak) and 27
C-NMR peak: 210, 55, 34, 22, 18
NMR spectra (): 2.4 (2H, triplet), 2.1 (3H, singlet), 1.7 (2H, hextet), 0.9 (3H, triplet)
3.
a) What is Hooke's law? Write its importance in IR spectroscopy.
b) What are the difference between dispersive and FT-IR spectrophotometer?
c) How will you identify the following functional groups in an organic compound?
OH-, -NH2, --COOR, -C=C-, -CHO
4.
Write a note on any FIVE only
a) Atomic absorption spectroscopy
b) HPTLC
c) Precolumn derivatisation technique
d) Octant rule
e) Bravis's lattices
f) Test for statistical significance and Student `T' test
5.
a) Explain Woodward's rule and its applications in structural elucidation.
b) Explain in detail any two methods for simultaneous estimation of multicomponent sample by
UV Spectrophotometry.
c) Explain principle and working of phototube and photomultiplier tube detector in UV-Visible
spectrophotometer.
6.
a) Write the principles of gas chromatography. Draw a neat labeled diagram of GC instrument
and explain any two detectors used.
b) Explain the principle of super critical fluid chromatography.
c) What are theoretical plates? Explain Van-Deemter equation.
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