Download RGUHS M.Pharm 1st Year 2020 5112 Advanced Pharmaceutical Analysis Question Paper

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1. Explain the principle and procedure of assay as per IP for the following methods
   1. Non-aqueous titrations
   2. Potentiometric titrations

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2. Explain the principle and applications of the following reagents
   1. Methyl -2 benzthiazolinone hydrazine(MBTH)
   2. Para-dimethyl —amino benzaldehyde (PDAB)
3. Explain the principle and procedure involved in quantitative estimation of drugs containing following functional groups/Element.
   1. Carboxyl group
   2. Halogen group

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4. Describe in detail the biological assay of Adsorbed Diphtheria vaccine.

SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks

1. Describe analysis of any one drug by RP-HPLC.
2. Explain in brief analysis of any one drug by UV-extinction method.

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3. Explain the principle and applications of 2, 6 Dichloroquinone chlorimide in drug analysis?
4. Write the procedure and applications of 1, 2 - napthaquinone-4-sulfonate in drug analysis?
5. Explain a method for determination of calcium.
6. Explain the principle and procedure of any one method for the estimation of Sodium.
7. Describe in brief biological assay of Oxytocin.

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8. Write a brief note on biological assay of Heparin sodium IP.
9. Classify residual solvents and describe their permissible limits in drug products.
10. Write a brief note on potential sources of elemental impurities.

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