RGUHS M.Pharm 2nd Year Last 10 Years 2011-2021 Question Papers || Rajiv Gandhi University of Health Sciences
LONG ESSAY (Answer all questions) 3 x 15 = 45 Marks
- Explain the various mechanisms that determine drug solubility?
- Discuss in detail one-compartment open model for a drug administered extravascularly. Give the schematic representation, graphs and equations for the same.
- Explain the biopharmaceutical considerations in drug development design.
- Define Bioequivalence. Explain the purpose of bioequivalence studies.
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SHORT ESSAY (Answer any Nine) 9 X 5 = 45 Marks
- Write a short note of pH partition hypothesis.
- Write Noyes-Whitney equation. What are the factors affecting dissolution rate?
- What is effect of tablets on drug absorption?
- Discuss the various study designs in for performing bioavailability.
- Explain various pharmacokinetic parameters after oral administration of drug.
- Write about the advantages and disadvantages of compartment modeling.
- What are the special concerns in performing bioequivalence studies for generic substitution?
- Describe the application of pharmacokinetics in the development of biotechnological products.
- Write a short note on biosimilar drug products.
- Explain the various factors leading to non-linearity.
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