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THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[MBBS 0924]
SEPTEMBER 2024 Sub. Code :6056
M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2020 -2021 Onwards)
FIRST PROFESSIONAL ? (CBME) - SUPPLEMENTARY
PAPER II ? BIOCHEMISTRY
Q.P. Code: 526056
Time: 20 Minutes
Maximum : 20 Marks
Answer All Questions
Choose one correct answer in the box provided in the Answer Script.
No overwriting should be done. Choice should be given in Capital Letters.
III. Multiple Choice Questions:
(20 x 1 = 20)
1. The most common form of DNA is,
A) B DNA B) Z DNA C) A DNA D) E DNA
2. The features of B DNA include, all EXCEPT
A) It is a right-handed helix
B) One full turn of DNA has 10 nucleotides and measure 34A0 , width 20A0
C) Major groove is equal to minor groove in terms of width
D) It is the form that is present under physiological conditions
3. C2 of pyrimidine ring is donated by
A) N5, N10 methylene THFA B) N10 formyl THFA
C) N5, N10 methenyl THFA D) Carbon dioxide
4. Base excision repair is done by
A) Apurinic endonuclease B) DNA polymerase
C) GATC endonuclease D) Ku helicase
5. Which of the following is best described as being trans-acting?
A) CAP site B) Operator C) Promoter D) Repressor
6. Amino acids, which carry nitrogen to the liver from peripheral tissues, include
A) Alanine and glutamine B) Arginine and ornithine
C) Glutamate and aspartate D) Branched chain amino acids
7. A couple of African American descent gives birth to a boy after an otherwise
uneventful pregnancy. The child is exceptionally fair- skinned and has almost white
hair. Further examination reveals red pupils. A postnatal screen is likely to confirm the
deficiency of which of the following enzymes in the child?
A) Inducible nitric oxide synthase (iNOS) B) Glutathione reductase
C) Tyrosinase
D) Phenylalanine hydroxylase
8. A 56-year-old woman with no known medical conditions presents to the emergency
room with pain in the upper arm. She denies any trauma; however, a fracture of the
humerus is found on radiograph. She is found to have an elevated PTH level. Which
of the following statements best describes PTH?
A) It lowers serum calcium
B) It stimulates the conversion of vitamin D to the active form
C) It promotes the reabsorption of phosphate from the kidney
D) It promotes the excretion of calcium from the kidney
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9. Methotrexate is often used as a chemotherapeutic agent to treat patients with leukemia.
This drug is effective because it inhibits cells in which part of the cell cycle?
A) G1 phase B) S phase C) M phase D) G2 phase
10. The effect of thyroid hormones on CVS includes all EXCEPT:
A) Decreases peripheral resistance B) Increases heart rate
C) Increases stroke volume D) Increases diastolic BP
11. The mutation seen in Sickle cell anemia is:
A) A missense point mutation B) A nonsense point mutation
C) An insertion D) A frameshift mutation
12. The backbone of a DNA strand is composed of which of the following?
A) Sugars and bases B) Phosphates and sugar
C) Bases and phosphates D) Nucleotides and sugars
13. Which of the following enzymes is required to actively enhance the separation of
DNA strands during replication?
A) Helicase B) 3' to 5'exonuclease C) DNA ligase D) Primase
14. Chaperone plays a role in
A) Increases the activity of inactive protein B) protein folding
C) Prevent the activity of harmful proteins D) All the above
15. The Kidney contributes to acid-base balance by
A) production of 25- hydroxycholecalciferol B) Reclamation of bicarbonate
C) Increased ketogenesis D) Renin ? angiotensin synthesis
16. A suppressed TSH and raised free T3 and T4 indicate
A) Thyrotoxicosis B) Myxoedema
C) Cretinism D) Subclinical Hyperthyroidism
17. The separation of molecules based on their size, is done by
A) Ion exchange chromatography B) Gel filtration chromatography
C) Adsorption chromatography D) Affinity chromatography
18. Hartnup's disease is associated with defective absorption of the following amino acid
A) Tryptophan B) Alanine C) Proline D) Arginine
19. Selenium is a co factor in which of the following enzymes
A) Glutathione peroxidase B) Cytochrome oxidase
C) Cytochrome reductase D) Xanthine oxidase
20. All the following conditions leads to hypernatremia EXCEPT
A) Vomiting and diarrhoea B) Burns
C) Addison's disease D) Cushing's syndrome.
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[MBBS 0924]
This post was last modified on 30 November 2024