2019 Scheme
Q.P. Code: 216001
Reg. no.: .....................
Second Professional MBBS Degree Regular/Supplementary Examinations
December 2024
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Indicate the question number correctly for the answer in the margin space
Draw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(20x1=20)
The Answers to MCQ questions (Q.No. i to Q.No. xx) shall be written continuously on the first two
Read the following clinical history and select the most appropriate response for questions (i) -(v)
A 4 year old boy was brought to the emergency with a history of altered sensorium, inability to eat and one
episode of seizure in the last 2 days. The child used to play with street dogs.
i. What is the likely clinical diagnosis
c) Rabies
b) ECHO virus encephalitis
d) Herpes Simplex encephalitis
ii. An antemortem diagnostic method is
c) Antibody detection in saliva
b) Antigen in corneal smear by immunofluorescence d) RNA in brain by RTPCR
iii. Vaccine to prevent rabies in humans is
a) Sheep brain vaccine
iv. Rabies virus can be transmitted to humans by all of the following routes EXCEPT
a) Bite by infected bats
c) Cornea transplantation
b) Inhalation of virus containing aerosols
v. The protein which acts as virulence factor is the
a) Nucleoprotein
b) Glycoprotein G c) Matrix protein d) Hemagglutinin
Question numbers (vi)-(x) are multiple response type questions. Read the statements & mark the
vi. Cholera
1) Has potential to cause pandemics
2) Hanging drop test of stool sample helps in rapid diagnosis
3) Causes dysentery in children
a) 1, 2, 3 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 4 are correct
vii. Bile-stained eggs are seen in infection with
1) Ascaris
2) Hookworm
4) Taenia
a) 1, 2, 3 are correct b) 1, 2, 4 are correct c) 1, 3, 4 are correct d) 2, 3, 4 are correct
viii. Hand foot and mouth disease is NOT caused by
1) Cytomegalovirus
a) 1, 2, 3 are correct b) 2, 3, 4 are correct c) 1, 3, 4 are correct d) 1, 2, 4 are correct
ix. This is NOT a mode of transmission of Schistosoma hematobium
1) Bite of Tsetse fly
2) Consumption of vegetables contaminated with metacercaria
a) 2, 3, 4 are correct b) 1, 2, 3 are correct c) 1, 3, 4 are correct d) 1, 2, 4 are correct
x. A 28 year old male, following consumption of canned food, came with complaints of difficulty in
swallowing, blurred vision, which soon progressed to respiratory paralysis. This bacteria is NOT the
likely etiology.
2) Clostridium botulinum
3) Campylobacter jejuni 4) Yersinia enterocolitica
a) 1, 2, 4 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 3 are correct
Question numbers (xi) ? (xv) are single response types
a) Acanthamoeba
b) Naegleria
c) Balamuthia d) Sappinia
xii. Meningitis caused by the following agents can be prevented by vaccination EXCEPT
c) Hemophilus influenzae
b) Streptococcus pneumoniae
d) Listeria monocytogenes
(PTO)
xiii. Swimming pool granuloma is caused by Mycobacterium
a) marinum
b) kansasii
c) ulcerans
xiv. River blindness is caused by
a) Brugia malayi
b) Oncocerca volvulus
c) Loa loa
xv. Diphtheria vaccine is a
a) Subunit vaccine
b) Toxoid vaccine
c) Whole cell vaccine d) Recombinant vaccine
questions by selecting the appropriate options given below.
xvi. A: Whooping cough is caused by Bordetella pertussis.
R: Whooping cough is mainly seen in adults.
a) Both A and R are true and R is the correct explanation of A
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
xvii. A: Specific antivirals are available to treat Japanese Encephalitis.
R: Japanese Encephalitis is the most common cause of vaccine preventable encephalitis in Asia.
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
xviii. A: Cryptococcus neoformans cannot be cultured.
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
R: Hepatitis B can be transmitted parenterally.
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
xx. A: Plasmodium falciparum is the species of Plasmodium producing most serious complications.
R: Malaria is caused by bite of female Anopheles mosquito
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
d) A is false but R is true
Essays
(2x10=20)
2. A 70 year old man was brought to the emergency department with fever, cough, and dyspnoea. Physical
gram stain of sputum sample revealed numerous pus cells and Gram positive lanceolate shaped
diplococci.
a) What is the clinical diagnosis and what is the probable etiological agent.
b) What culture media is used to enable the growth of the organism suspected and how will you confirm
c) Discuss the virulence factors and pathogenesis of this etiological agent.
d) What are the vaccines available for this etiological agent. Discuss.
(2+3+3+2)
3. A 30 year old female was brought to the hospital with complaints of loss of weight and appetite of
blood transfusion in the past. Lab investigation showed she was HBsAg positive.
a) What is the most probable clinical diagnosis.
b) What are the different modes of transmission of this agent.
c) Discuss the laboratory diagnosis of this infection.
(1+2+5+2)
Short Essays
(6X6=36)
5. Define pandemic. Name any four pandemics. Describe in detail strategies taken for their control. (1+2+3)
6. List FOUR clinically important anaerobes. List samples to be collected. Describe the sample collection
process.
(2+2+2)
8. Mode of transmission, clinical presentation and laboratory diagnosis of Nipah virus infection (2+2+2)
9. Shigellosis.
Short Answers
10. Antibiotic associated diarrhea.
11. List, in tabular form, the CSF parameters, in normal CSF and in pyogenic, viral and tubercular meningitis.
12. How will you instruct a patient with suspected lower respiratory tract infection to collect a sputum sample.
13. How is Toxoplasma gondii transmitted. Add a note on the laboratory diagnosis of congenital Toxoplasma
14. Modes of transmission and laboratory diagnosis of Monkey pox (M Pox)
15. List FOUR oncogenic viruses.
***************************
Q.P. Code: 216001
Reg. no.: .....................
Second Professional MBBS Degree Regular/Supplementary Examinations
December 2024
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Microbiology Paper IITime: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Indicate the question number correctly for the answer in the margin space
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Answer all parts of a single question together ? Leave sufficient space between answersDraw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(20x1=20)
The Answers to MCQ questions (Q.No. i to Q.No. xx) shall be written continuously on the first two
--- Content provided by FirstRanker.com ---
writing sheets (ie Page No. 3 & 4) onlyRead the following clinical history and select the most appropriate response for questions (i) -(v)
A 4 year old boy was brought to the emergency with a history of altered sensorium, inability to eat and one
episode of seizure in the last 2 days. The child used to play with street dogs.
i. What is the likely clinical diagnosis
--- Content provided by FirstRanker.com ---
a) Guillain barre syndromec) Rabies
b) ECHO virus encephalitis
d) Herpes Simplex encephalitis
ii. An antemortem diagnostic method is
--- Content provided by FirstRanker.com ---
a) Negri bodies in brain by Immunohistochemistryc) Antibody detection in saliva
b) Antigen in corneal smear by immunofluorescence d) RNA in brain by RTPCR
iii. Vaccine to prevent rabies in humans is
a) Sheep brain vaccine
--- Content provided by FirstRanker.com ---
b) Neural vaccine c) Human diploid cell vaccine d) Jeryl Lynn vaccineiv. Rabies virus can be transmitted to humans by all of the following routes EXCEPT
a) Bite by infected bats
c) Cornea transplantation
b) Inhalation of virus containing aerosols
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d) Consumption of raw milk of infected animalsv. The protein which acts as virulence factor is the
a) Nucleoprotein
b) Glycoprotein G c) Matrix protein d) Hemagglutinin
Question numbers (vi)-(x) are multiple response type questions. Read the statements & mark the
--- Content provided by FirstRanker.com ---
answers appropriately.vi. Cholera
1) Has potential to cause pandemics
2) Hanging drop test of stool sample helps in rapid diagnosis
3) Causes dysentery in children
--- Content provided by FirstRanker.com ---
4) Can present as hypovolemic shock in severe cases leading to deatha) 1, 2, 3 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 4 are correct
vii. Bile-stained eggs are seen in infection with
1) Ascaris
2) Hookworm
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3) Trichuris4) Taenia
a) 1, 2, 3 are correct b) 1, 2, 4 are correct c) 1, 3, 4 are correct d) 2, 3, 4 are correct
viii. Hand foot and mouth disease is NOT caused by
1) Cytomegalovirus
--- Content provided by FirstRanker.com ---
2) Coxsackie virus 3) Calicivirus 4) ECHO virusa) 1, 2, 3 are correct b) 2, 3, 4 are correct c) 1, 3, 4 are correct d) 1, 2, 4 are correct
ix. This is NOT a mode of transmission of Schistosoma hematobium
1) Bite of Tsetse fly
2) Consumption of vegetables contaminated with metacercaria
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3) Penetration of cercaria through the skin 4) Blood transfusiona) 2, 3, 4 are correct b) 1, 2, 3 are correct c) 1, 3, 4 are correct d) 1, 2, 4 are correct
x. A 28 year old male, following consumption of canned food, came with complaints of difficulty in
swallowing, blurred vision, which soon progressed to respiratory paralysis. This bacteria is NOT the
likely etiology.
--- Content provided by FirstRanker.com ---
1) Enterotoxigenic Escherichia coli2) Clostridium botulinum
3) Campylobacter jejuni 4) Yersinia enterocolitica
a) 1, 2, 4 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 3 are correct
Question numbers (xi) ? (xv) are single response types
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xi. Which of the following parasites causes keratitis.a) Acanthamoeba
b) Naegleria
c) Balamuthia d) Sappinia
xii. Meningitis caused by the following agents can be prevented by vaccination EXCEPT
--- Content provided by FirstRanker.com ---
a) Neisseria meningitidisc) Hemophilus influenzae
b) Streptococcus pneumoniae
d) Listeria monocytogenes
(PTO)
--- Content provided by FirstRanker.com ---
xiii. Swimming pool granuloma is caused by Mycobacterium
a) marinum
b) kansasii
c) ulcerans
--- Content provided by FirstRanker.com ---
d) abscessusxiv. River blindness is caused by
a) Brugia malayi
b) Oncocerca volvulus
c) Loa loa
--- Content provided by FirstRanker.com ---
d) Mansonella speciesxv. Diphtheria vaccine is a
a) Subunit vaccine
b) Toxoid vaccine
c) Whole cell vaccine d) Recombinant vaccine
--- Content provided by FirstRanker.com ---
Question numbers (xvi) ? (xx) consists of two Statements-Assertion (A) and Reason (R). Answer thesequestions by selecting the appropriate options given below.
xvi. A: Whooping cough is caused by Bordetella pertussis.
R: Whooping cough is mainly seen in adults.
a) Both A and R are true and R is the correct explanation of A
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c) A is true but R is falseb) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
xvii. A: Specific antivirals are available to treat Japanese Encephalitis.
R: Japanese Encephalitis is the most common cause of vaccine preventable encephalitis in Asia.
--- Content provided by FirstRanker.com ---
a) Both A and R are true and R is the correct explanation of Ac) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
xviii. A: Cryptococcus neoformans cannot be cultured.
--- Content provided by FirstRanker.com ---
R: Rapid diagnosis of Cryptococcal meningitis can be done on CSF sample by India Ink preparation.a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
d) A is false but R is true
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xix. A: Hepatitis B virus is preventable by vaccination.R: Hepatitis B can be transmitted parenterally.
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true and R is not the correct explanation of A
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d) A is false but R is truexx. A: Plasmodium falciparum is the species of Plasmodium producing most serious complications.
R: Malaria is caused by bite of female Anopheles mosquito
a) Both A and R are true and R is the correct explanation of A
c) A is true but R is false
--- Content provided by FirstRanker.com ---
b) Both A and R are true and R is not the correct explanation of Ad) A is false but R is true
Essays
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(2x10=20)
2. A 70 year old man was brought to the emergency department with fever, cough, and dyspnoea. Physical
--- Content provided by FirstRanker.com ---
examination revealed a dull note on percussion. X-ray chest revealed a patch on the right lung area. Thegram stain of sputum sample revealed numerous pus cells and Gram positive lanceolate shaped
diplococci.
a) What is the clinical diagnosis and what is the probable etiological agent.
b) What culture media is used to enable the growth of the organism suspected and how will you confirm
--- Content provided by FirstRanker.com ---
the identity of the organism.c) Discuss the virulence factors and pathogenesis of this etiological agent.
d) What are the vaccines available for this etiological agent. Discuss.
(2+3+3+2)
3. A 30 year old female was brought to the hospital with complaints of loss of weight and appetite of
--- Content provided by FirstRanker.com ---
3 months duration. On examination, she was jaundiced and hepatomegaly present. she gave a history ofblood transfusion in the past. Lab investigation showed she was HBsAg positive.
a) What is the most probable clinical diagnosis.
b) What are the different modes of transmission of this agent.
c) Discuss the laboratory diagnosis of this infection.
--- Content provided by FirstRanker.com ---
d) Add a note on the immunoprophylaxis.(1+2+5+2)
Short Essays
(6X6=36)
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4. Hydatid disease.5. Define pandemic. Name any four pandemics. Describe in detail strategies taken for their control. (1+2+3)
6. List FOUR clinically important anaerobes. List samples to be collected. Describe the sample collection
process.
(2+2+2)
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7. Primary Amoebic meningoencephalitis ? discuss etiology, pathogenesis and laboratory diagnosis.(1+2+3)8. Mode of transmission, clinical presentation and laboratory diagnosis of Nipah virus infection (2+2+2)
9. Shigellosis.
Short Answers
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(6x4=24)10. Antibiotic associated diarrhea.
11. List, in tabular form, the CSF parameters, in normal CSF and in pyogenic, viral and tubercular meningitis.
12. How will you instruct a patient with suspected lower respiratory tract infection to collect a sputum sample.
13. How is Toxoplasma gondii transmitted. Add a note on the laboratory diagnosis of congenital Toxoplasma
--- Content provided by FirstRanker.com ---
infection.14. Modes of transmission and laboratory diagnosis of Monkey pox (M Pox)
15. List FOUR oncogenic viruses.
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