Download MBBS (Bachelor of Medicine and Bachelor of Surgery) KGMU (King George's Medical University) 1st Year (First Year) 2021 Biochemistry Paper I Previous Year Question Paper
M- 005M
MBBS FIRST PROFESSIONAL EXAM]NATION, 2021
BIOCHEMISTRY
Paper |
Time Allowed: Three Hours Maximum Marks- 100
Note:- Attempt all questions. All part of a question should be answered together. Figures in
parenthesis indicate marks allotted 10 a question.
Section-A
Q1. Write in detail about inter-relationship between various metabolic pathways, (20)
Q2. Write briefly on: (2x10)
(a) HMP Shunt pathway
(b) Detoxification of ammonia from brain
Q3. Multiple Choice Questions: (10x1)
A Molecular oxygen
b. Phenylalanine hydroxylase
c. Tetrahydrobiopterin
& FADH2
2. The diet of a child suffering from Maple Syrup Urine Disease
should be low in which of the following amino-acid content?
a. Tryptophan
b. Methionine
?. Phenylalanine
& Branched chain amino-acids
3. The deficiency of which of the following enzyme of pentose
phosphate pathway causes haemolytic anaemia?
a. Transketolase
b. Transaldolase
&~ Glucose-6-phosphate dehydrogenase
d. Phosphohexose isomerase
4. Disease associated with deficiency of Glucose-6-phosphatase in
liver:
3~ von Gierke?s Disease
b. Pompe?s Disease
?. McArdle Disease
d. Cori?s Disease
5. Insulin stimulates:
& Hepatic glycogenesis h
b. Hepatic glycogenolysis
?. Gluconeogenesis
e
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KGMU- Feb, 29y,
wing enzyme i i
diagnosis of Prostate cancfr? ? Homarker B
LA Acid phosphatase
b. Alkaline phosphatage
C. Amylase
d. Acetylase
7. Refsum?s Disease is
a. PB-oxidation
- @-oxidation
?. w-oxidation
d. Peroxisomes
8. Antimycin A, an inhibitor of Electron Tmnsport Chain inhibits the
flow of electrons from:
a. Complex |
b. Complex |1
e Complex I1]
due to defect in:
B Oxidative phosphorylation
b. Loop mechanism
?. Uncouplers
d. Ionophores
10. Activation of fatty acids requires all the following except:
o ATP
- - -
?. Thiokinase
Section-B
. e 20
1 Write in detail about important role of biochemistry in medicine. Add anoteon (20)
3 role of calcium in human body. ?
Q2. Write short notes on:
(a) Structure and functions proteins. -
(b) Km, Vmax and regulation of enzyme activities. s
iple Choice Questions: .
5 Mulltl : The amino acid which contains an indole group is:
" a Histidine
b. Arginine
c. Cystine
_d- Tryptophan denylate cyclase
<8 ATP by the enzyme aden
is formed from AT
2. Cyeclic AMP
which is activated by the hormone: Z
a lnsulin
vb? Epinephrine
c. Testosterone
d. Progesterone
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KGMLUL. Feh 2021
mRrN s
RP"?A polymerase 11
(?) RNA polymerase 111
rase |V
4 Which of the fol
lowing is know )
of antigen to T- lym o 10 be invalved in the initial presentation
L) Dendritic cally T initial presen
(b) Plasma cells
(?) Plaelets
d) El?)r?htocylc?
- l?erfo?. isa protein
(a) Helper T CCT
(b) Cytotoxic T cell
JeT Natura) killer cell
(d) Suppressor T cell
6. Memory cells ure formed from:
(a) Erythropoietic stem cells
(b) Monocytes
LeT"T- lymphocytes
(d) B- lymphocytes
7. For measurement of HbAlc sample blood specimen is collected in 2 tube
containing aniicoagulant:
(2) Sodium fluoride
ium citrate
(c) Heparin
(d) EDTA
8. Which fraction of bilirubin can cross blood brain barrier and enter the
neurons of basal ganglia, hippocampus and cerebhellum causing necrosis
of nerve cells leading to the development of bilirubin encepbalopathy?
(a) Del irubin
(b)Hrconjugated bilirubin
ic) Bilirubin mono-glucuronide
(d) Bilirubin di-glucuronide
9. Which one Is the most common cause of raised nWld bilirubie in
n ysiological Jaundice of Newborn?
Reduced activity of UDP-glucuronosy|-transferase enzyme
(b) Cholestasis X B
(c) Blood group incompatibility.~
(d) G6PD deficiency
10. Elevated homocysteine levels are associated with:
secreted by:
artery discase
(b) Bronchitis
(?) Common cold
(d) Diarrhoca
Section-B
Vitamin D3 is a prohormone and calcitriol is a hormone ? Justify the statement. (20)
. W soch :ui:ll?m' nd deficiency disorders of Vitamin D
5 - " ) . (2x10)
What cmlulW? Write briefly about the biochemical basis of
a) arc
the odeol:n?oufaywlmmwhhwhdpnhweu
b) Describe the m orm
) jabelled diagram.
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Q3.
Multiple Choice Questions:
1.
A lumorhsuppressor gene is:
L] Inactivated by mutation
(b) Activated by mutation?
(?) Functional during tumor formation
(d) Metastasis promoting gene
2. Retrovirus can induce cancer by:
(a) Injeeting oncogenes into the cells
onverting proto-oncogenes into oncogenes
(?) Causing mutations in G proteins
(d) Suppressing p53
3. Whi the following enzyme is deficient in Gaucher's disease?
lucosidase (glucocerebrosidase)
" (b) Glucoceramide
(c) Sphingomyelinase
(d) Galactosidase
4. Thyroid hormones are transported in blood bound to:
yroxine binding prealbumin
(b) Transcortin
(c) Sex hormone binding globulin
(d) Thyroglobulin
5. The temporary storage form of iron in intestinal mucosal cell is:
(a) Hemosiderin
(b) Transferrin
qm?f:;:in
d) Haemoglobin . .
6. %Znnl lu_hi defect is associated with the deficiency of:
(arPy?doxinc
(b) Thiamine
w (c)AFolate
(d) Cobalamine 2 ) .
7. The vitamin deficient in maize is:
(a) Thiamine
(b) Ratoflavin
Niacin
d) Pyridoxine ) - .
8 SI'Inin nelndJSbeuLpnmm?gd by
?nsketolase level l?:ol:iloo
Eb; g;?u?g?sl:i ??I?l::sphate dehydrogenase activity
c .
(d) Reticulocytosis
KGMU- Feb, 2021
(10x1)
9 Bi di 0 0/ o'i. Ilo?l!OleS to melzlol activate ad BV? \C?
. n .? f t?e f ? g ivat ? < ase
except .
Vasopressint
(b)_Glucagon
yroxine
%:inephrine
th h:
10. Carqtenss are transported (hrOUE
"4y Proteins
b) Lipids
EC) Minerals .
v(d% Lipopfmell?
e
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This post was last modified on 01 December 2021