Download MBBS KGMU 1st Year 2021 Biochemistry Paper I Question Paper

Note:- Attempt all questions. All part of a question should be answered together. Figures in parenthesis indicate marks allotted to a question.

Section-A

Q1. Write in detail about inter-relationship between various metabolic pathways. (20)

Q2. Write briefly on: (2x10)

1. HMP Shunt pathway

--- Content provided by⁠ FirstRanker.com ---

2. Detoxification of ammonia from brain

Q3. Multiple Choice Questions: (10x1)

1. Hydroxylation of phenylalanine requires all of the following EXCEPT
   1. Molecular oxygen
   2. Phenylalanine hydroxylase
   3. Tetrahydrobiopterin

   --- Content provided by‌ FirstRanker.com ---

   4. FADH2
2. The diet of a child suffering from Maple Syrup Urine Disease should be low in which of the following amino-acid content?
   1. Tryptophan
   2. Methionine
   3. Phenylalanine

   --- Content provided by FirstRanker.com ---

   4. Branched chain amino-acids
3. The deficiency of which of the following enzyme of pentose phosphate pathway causes haemolytic anaemia?
   1. Transketolase
   2. Transaldolase
   3. Glucose-6-phosphate dehydrogenase

   --- Content provided by‌ FirstRanker.com ---

   4. Phosphohexose isomerase
4. Disease associated with deficiency of Glucose-6-phosphatase in liver:
   1. von Gierke's Disease
   2. Pompe's Disease
   3. McArdle Disease

   --- Content provided by​ FirstRanker.com ---

   4. Cori's Disease
5. Insulin stimulates:
   1. Hepatic glycogenesis
   2. Hepatic glycogenolysis
   3. Gluconeogenesis

   --- Content provided by⁠ FirstRanker.com ---

   4. Lipolysis
6. Which one of the following enzyme acts as biomarker in the diagnosis of prostate cancer?
   1. Acid phosphatase
   2. Alkaline phosphatase
   3. Amylase

   --- Content provided by‍ FirstRanker.com ---

   4. Acetylase
7. Refsum's Disease is due to defect in:
   1. β-oxidation
   2. α-oxidation
   3. ω-oxidation

   --- Content provided by FirstRanker.com ---

   4. Peroxisomes
8. Antimycin A, an inhibitor of Electron Transport Chain inhibits the flow of electrons from:
   1. Complex I
   2. Complex II
   3. Complex III

   --- Content provided by⁠ FirstRanker.com ---

   4. Complex IV
9. Pumping of the hydrogen ions between two membranes of mitochondria from the matrix is best explained by which of the following:
   1. Oxidative phosphorylation
   2. Loop mechanism
   3. Uncouplers

   --- Content provided by‌ FirstRanker.com ---

   4. Ionophores
10. Activation of fatty acids requires all the following except:
    1. ATP
    2. Coenzyme A
    3. Thiokinase

    --- Content provided by FirstRanker.com ---

    4. Carnitine

Section-B

Q1. Write in detail about important role of biochemistry in medicine. Add a note on (20) role of calcium in human body.

Q2. Write short notes on: (2x10)

--- Content provided by⁠ FirstRanker.com ---

1. Structure and functions proteins.
2. Km, Vmax and regulation of enzyme activities.

Q3. Multiple Choice Questions: (10x1)

1. The amino acid which contains an indole group is:
   1. Histidine
   2. Arginine

   --- Content provided by​ FirstRanker.com ---

   3. Cystine
   4. Tryptophan
2. Cyclic AMP is formed from ATP by the enzyme adenylate cyclase which is activated by the hormone:
   1. Insulin
   2. Epinephrine

   --- Content provided by FirstRanker.com ---

   3. Testosterone
   4. Progesterone
3. The synthesis of mRNA in human is catalyzed by:
   1. RNA polymerase I
   2. RNA polymerase II

   --- Content provided by FirstRanker.com ---

   3. RNA polymerase III
   4. RNA polymerase IV
4. Which of the following is known to be involved in the initial presentation of antigen to T-lymphocytes?
   1. Dendritic cells
   2. Plasma cells

   --- Content provided by FirstRanker.com ---

   3. Platelets
   4. Erythrocytes
5. Perforin is a protein secreted by:
   1. Helper T cell
   2. Cytotoxic T cell

   --- Content provided by​ FirstRanker.com ---

   3. Natural killer cell
   4. Suppressor T cell
6. Memory cells are formed from:
   1. Erythropoietic stem cells
   2. Monocytes

   --- Content provided by‌ FirstRanker.com ---

   3. T-lymphocytes
   4. B-lymphocytes
7. For measurement of HbA1c sample blood specimen is collected in a tube containing anticoagulant:
   1. Sodium fluoride
   2. Sodium citrate

   --- Content provided by​ FirstRanker.com ---

   3. Heparin
   4. EDTA
8. Which fraction of bilirubin can cross blood brain barrier and enter the neurons of basal ganglia, hippocampus and cerebellum causing necrosis of nerve cells leading to the development of bilirubin encephalopathy?
   1. Delta bilirubin
   2. Unconjugated bilirubin

   --- Content provided by⁠ FirstRanker.com ---

   3. Bilirubin mono-glucuronide
   4. Bilirubin di-glucuronide
9. Which one is the most common cause of raised unconjugated bilirubin in a case of Physiological Jaundice of Newborn?
   1. Reduced activity of UDP-glucuronosyl-transferase enzyme
   2. Cholestasis

   --- Content provided by​ FirstRanker.com ---

   3. Blood group incompatibility
   4. G6PD deficiency
10. Elevated homocysteine levels are associated with:
    1. Coronary artery disease
    2. Bronchitis

    --- Content provided by‌ FirstRanker.com ---

    3. Common cold
    4. Diarrhoea

Section-B

Q1. Vitamin D3 is a prohormone and calcitriol is a hormone - Justify the statement. (20) Describe the synthesis, biochemical functions and deficiency disorders of Vitamin D

--- Content provided by‍ FirstRanker.com ---

Q2. Write short notes on: (2x10)

1. What are chemical carcinogens? Write briefly about the biochemical basis of cancer chemotherapy.
2. Describe the mode of action for group I hormones with the help of a well labelled diagram.

Q3. Multiple Choice Questions: (10x1)

1. A tumor suppressor gene is:
   1. Inactivated by mutation

   --- Content provided by‌ FirstRanker.com ---

   2. Activated by mutation
   3. Functional during tumor formation
   4. Metastasis promoting gene
2. Retrovirus can induce cancer by:
   1. Injecting oncogenes into the cells

   --- Content provided by​ FirstRanker.com ---

   2. Converting proto-oncogenes into oncogenes
   3. Causing mutations in G proteins
   4. Suppressing p53
3. Which of the following enzyme is deficient in Gaucher's disease?
   1. Glucosidase (glucocerebrosidase)

   --- Content provided by‌ FirstRanker.com ---

   2. Glucoceramide
   3. Sphingomyelinase
   4. Galactosidase
4. Thyroid hormones are transported in blood bound to:
   1. Thyroxine binding prealbumin

   --- Content provided by FirstRanker.com ---

   2. Transcortin
   3. Sex hormone binding globulin
   4. Thyroglobulin
5. The temporary storage form of iron in intestinal mucosal cell is:
   1. Hemosiderin

   --- Content provided by​ FirstRanker.com ---

   2. Transferrin
   3. Ferritin
   4. Haemoglobin
6. Neural tube defect is associated with the deficiency of:
   1. Pyridoxine

   --- Content provided by‍ FirstRanker.com ---

   2. Thiamine
   3. Folate
   4. Cobalamine
7. The vitamin deficient in maize is:
   1. Thiamine

   --- Content provided by​ FirstRanker.com ---

   2. Riboflavin
   3. Niacin
   4. Pyridoxine
8. Thiamine level is best monitored by:
   1. Transketolase level in blood

   --- Content provided by⁠ FirstRanker.com ---

   2. Thiamine level in blood
   3. Glucose-6-phosphate dehydrogenase activity
   4. Reticulocytosis
9. Binding of the following hormones to receptor activate adenyl cyclase except:
   1. Vasopressin

   --- Content provided by‌ FirstRanker.com ---

   2. Glucagon
   3. Thyroxine
   4. Epinephrine
10. Carotenes are transported through:
    1. Proteins

    --- Content provided by⁠ FirstRanker.com ---

    2. Lipids
    3. Minerals
    4. Lipoproteins

FirstRanker.com

--- Content provided by​ FirstRanker.com ---