Download KUHS First Year (1st Year) 2023 November 116001 Biochemistry Paper II Previous Question Paper
Q.P. Code: 116001
Reg. no.: .....................
First Professional MBBS Degree Regular/Supplementary Examinations
November 2023
Biochemistry - Paper II
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers ?
Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together ? Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
Long Essays
(2x15=30)
1. A 54-year-old man was admitted to emergency in a disoriented state. He had a feeble
pulse, low blood pressure and sweetish odour of breath. Arterial blood gas analysis
showed pH : 7.1, HCO3 :11 mmol/L, pCO2 : 38 mmHg.
a) What is the most likely acid base disorder in this case
b) Interpret the ABG findings and give the normal reference interval
c) Give four causes for the above acid base disorder
d) Enumerate the major buffer systems in the body
e) Discuss the renal regulatory mechanisms of acid base balance
(1+3+4+3+4)
2. Describe the absorption, transport and storage of iron in the body. Explain the
regulation of iron homeostasis. Enumerate the biochemical functions of iron. Add a
note on disorders associated iron metabolism.
(6+3+2+4)
Short essays
(5x8=40)
3. Give the sources of carbon and nitrogen atoms of purine and pyrimidine rings. How is
the de novo synthesis regulated. Indicate the clinical uses of inhibitors of purine
nucleotide synthesis.
(2+2+2+2)
4. Describe the process of DNA replication in eukaryotes. Name two inhibitors of
replication.
(6+2)
5. Describe recombinant DNA technology. Add a note on its applications.
(5+3)
6. Name the renal clearance tests. Give details of any one of them. What is its clinical
significance
(3+4+1)
7. Enumerate the immunoglobulin and classify their functions. Describe the structure of
immunoglobulins.
(5+3)
Short answers
(5x4=20)
8. Oncogenes
9. Hormonal regulation of calcium level
10. Van den Bergh test
11. Post translational modifications.
12. Antioxidants
Give Precise Answers
(10x1=10)
13. Hyperkalaemia is treated by giving glucose and insulin. Why
14. Name two antimutagens
15. Enlist two applications of Southern blotting technique.
16. Name two vectors used for gene therapy.
17. What is apoptosis.
18. Name two inhibitors of RNA synthesis
19. Enzyme defect in orotic aciduria.
20. Name two copper containing enzymes.
21. Which amino acids are used for detoxification.
22. Give the reference interval in plasma to (a) Sodium (b) Chloride
***********************
This post was last modified on 02 December 2024