Download RGUHS (Rajiv Gandhi University of Health Sciences) MBBS (Bachelor of Medicine and Bachelor of Surgery) 2024 August 1025 Biochemistry Paper II Rs 4 Previous Question Paper
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase ? I (CBME) Degree Examination - 21-Aug-2024
Time: Three Hours
Max. Marks: 100 Marks
BIOCHEMISTRY ? PAPER II (RS-4)
Q.P. CODE: 1025
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS
2 x 10 = 20 Marks
1.
A 2 day old neonate was found to have yellowish discoloration of skin. Biochemical
investigation revealed: serum total bilirubin 5.5 mg/dl and serum direct bilirubin was 0.2
mg/dl.
a) Write biological reference interval for serum total bilirubin and serum direct
bilirubin.
b) Explain the formation and fate of bilirubin.
c) What is the biochemical basis for physiological jaundice?
d) Write the basis of giving phototherapy in a case of physiological jaundice.
2.
Describe the recombinant DNA technology and mention its applications in medicine.
SHORT ESSAYS
8 x 5 = 40 Marks
3. a) A 45 year old business executive after partying in the night with alcohol and red meat got
up in the morning with severe pain in the right toe. It was swollen. He rushed to a hospital
and his biochemical investigations were as follows: Serum creatinine: 0.9 mg/dl and
serum uric acid: 10mg/dl.
a) Interpret serum uric acid level in this patient
b) Explain the steps in the formation of uric acid
c) Explain role of allopurinol in this condition
4.
A 60 year old man who has a history of diabetes mellitus and hypertension, presented to
Nephrology OPD with swelling in the lower limb. His serum creatinine value was 3.8 mg/dl.
A diagnosis of chronic kidney disease was made.
a) Write biological reference interval for serum creatinine.
b) Explain creatinine clearance test.
5.
Explain mechanism of action of steroid hormones.
6.
Classify plasma proteins. Describe the functions of albumin.
7.
Explain DNA replication in prokaryotes.
8.
Explain urea cycle. Mention its regulation.
9.
Describe post-transcriptional modifications of RNA.
10. Explain secondary structural organisation of protein.
SHORT ANSWERS
10 x 3 = 30 Marks
11. Define Transamination and mention the importance of Transamination.
12. Write the characteristics of genetic code.
13. Write the role of p53 protein in cancer.
14. How is aspirin detoxified in the body?
15. Write three examples of transmethylation reactions.
16. Name three biologically important nucleotides and write their functions.
17. Enumerate three classes of immunoglobulins and write their functions.
18. Name the antioxidant enzymes and write the biochemical reaction of anyone of them.
19. Mention any three pre-analytical variables encountered in the clinical laboratory.
20. Write the reactions of purine salvage pathway.
Page 1 of 2
QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
Multiple Choice Questions
10 x 1 = 10 Marks
21 i) The following are carcinogens EXCEPT
A. Aflatoxin
B. Gamma rays
C. Benzopyrene
D. Actinomycin
21 ii
) The class of antibody most abundant in the serum is
A. IgG
B. IgM
C. IgA
D. IgE
21 ii
i) Which of the following amino acids is not found in proteins?
A. Arginine
B. Histidine
C. Methionine
D. Citrulline
21 iv)
Which of the following is a nucleotide?
A. Adenylic acid
B. Adenine
C. Adenosine
D. Agmantine
21 v)
Bilirubin is made water soluble by conjugation with
A. Lithocholic acid
B. Cholic acid
C. Glucuronic acid
D. Chenodeoxycholic acid
22 i) Serotonin is synthesized from
A. Tyrosine
B. Tryptophan
C. Phenylalanine
D. Proline
22
ii) Western blotting technique is used for the detection of
A. DNA
B. RNA
C. Proteins
D. Lipoproteins
22 iii) N1 of pyrimidine ring is contributed by
A. Glutamine
B. Aspartic acid
C. Glycine
D. Arginine
22 iv)
Which of the following cells does not produce free radicals?
A. Erythrocytes
B. Neutrophils
C. Basophils
D. Macrophages
22 v)
Test used to detect urobilinogen in urine is
A. Fouchet's test
B. Hay's test
C. Ehrlich's test
D. Rothera
's test
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This post was last modified on 02 December 2024