Download OU B.Pharma 2-1 Year 2013 7209 Pharmaceutical Analysis I Question Paper

Note: Answer all questions. All questions carry equal marks.

1. a) i) What are primary and secondary standard substances? Give examples. (8)
   OR
   

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   b) i) Define the terms :
   A) Specificity B) Sensitivity (4)
   C) Linearity D) Ruggedness
   ii) Explain the calibration of volumetric flask. (4)
   iii) A substance was known to contain 15.20 + 0.03% of a component, A. The results obtained by two experiments taking the same substance and employing the same analytical method as follows : (6)
   

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   Experiment—1 : % of A : 15.0, 15.31, 15.16 and 15.10
   Experiment—II : % of A : 15.30, 15.34, 15.36 and 15.36
   Discuss the results with reference to accuracy and precision of the measurements.
2. a) i) Calculate the pH of a 0.01 M acetic acid. (Dissociation constant pKa = 4.76). (4)
   ii) Write a note on different concepts of acid and bases. (6)
   

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   iii) Write a note on common ion effect. (4)
   OR
   b) i) Derive equations to calculate the pH value of aqueous solutions of salts obtained from weak acid and strong base. (10)
   ii) Write a note on amphoteric-substances by giving few examples. (4)
3. a) i) Describe the various steps involved in gravimetric analysis. (10)
   

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   ii) How do you prepare and standardize 0.1 N sodium thiosulphate? (4)
   OR
   b) i) Explain in-detail about redox indicators. (7)
   ii) Explain Volhard’s method for the determination of chlorides. (7)
4. a) i) Write about different solvents and indicators used in non-aqueous titration. (7)
   

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   ii) Discuss the theory and applications of complexometric analysis with examples. (7)
   OR
   b) i) Explain Iodometry and Iodimetry with examples. (7)
   ii) Write the principle and procedure involved in assay of calcium gluconate. (7)
5. a) i) Calculate the number of moles of sodium hydroxide in 500 ml. of 0.1 M sodium hydroxide solution. (4)
   

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   ii) Calculate the percentage composition of the elements in Na₂CO₃; [Na=23 , C=12, O=16]. (5)
   iii) 0.202 gm of a carbon compound on combustion gave 0.361 gm of CO₂ and 0.147 gm of water. Calculate the empirical formula of the compound. (5)
   OR
   b) i) Write the mass balance equation for the following : (2x3=6)
   A) Reaction between ammonium hydroxide and sulphuric acid
   

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   B) Reaction between sodium carbonate and hydrochloric acid
   ii) Calculate the percentage composition of the elements in Na₂S₂O₄ [Na=23, S=32, O=16]. (5)
   iii) Calculate the molarity of 17 g of pure Na₂CO₃ in 600 ml. of solution. (3)

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