Explain all the conjugation reactions involved in the drug metabolism.
Explain how the following properties influence the biological action of a drug molecule.
a) Partition coefficient (b) Chelation
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OR
Describe different prodrug approaches involved in the prolongation of drug activity and masking drug toxicity.
Explain the importance of bio-isosterism in drug design.
Explain the S.A.R. of ß-adrenergic blocking agents.
Write synthesis and uses of (a) Meprobamate (b) Dicyclomine.
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OR
Classify anti cholinergics giving two examples for each class with structures, mechanism of action and uses.
Write the synthesis and therapeutic uses of (a) Atenonol (b) Carbachol.
What are anti-arrythmic drugs? Classify them with examples.
Outline the synthesis, mechanism of action and uses of (a) Captopril (b) Nifedipine.
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OR
Classify anti hyper lipidemic agents with suitable example.
Write a note on cardiac glycosides and their mechanism of action.
Write the structure and uses of a) Clonidine b) Diltiazem
Give the classification of oral hypoglycemics agents with examples.
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Give the synthesis, mechanism of action and uses of a) Furosemide b) Tolbutamide
OR
Write a short note on Immuno modulator drugs.
Write a note on anti thyroid drugs and the synthesis of propylthio uracil.
Classify anti histamines / H1-receptor antagonists giving one example for each class with structures.
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Write the synthesis, mechanism of action and uses of a) Omeprazole (b) Ranitidine.
OR
Write the structural activity relationships and mechanism of action of proton pump inhibitors.
Write a note on anti-coagulants.
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This download link is referred from the post: OU B.Pharm Question Papers Last 10 Years 2010-2020 || Osmania University
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