Download MBBS UHS Lahore 3rd Year Special Pathology MCQ Question Paper

Download MBBS (Bachelor of Medicine and Bachelor of Surgery) UHS Lahore (University of Health Sciences Lahore) 3rd Year Special Pathology MCQ Previous Year Question Paper



Special Pathology

(Multiple Choice Questions)


A 58 -year-old man died after an episode of severe chest pain that radiated

to the back. Autopsy showed an intimal tear in the aortic wall 5cm from the

aortic valve with intramural aortic hematoma. Elastic tissue fragmentation

is noted in the aortic wall. What is the major risk factor predisposing to this


a) Hyperlipidemia

b) Cigarette smoking

c) Alcohol consumption

d) Hypertension

e) Defects in lipid metabolism


A patient who is a known case of hypertension and coronary artery disease

complains of severe chest pain radiating to left arm, while admitted to the

CCU for worsening angina. The pain does not subside with sublingual

nitroglycerine. ECG shows ST segment elevation. The registrar institutes

thrombolytic therapy within 20 minutes of onset of symptoms. What is the

most likely outcome if successful thrombolysis is achieved in this patient:

a) More than 80% of the myocardium at risk will be salvaged

b) Myocardial death will be prevented

c) More than 50% of the myocardium at risk would be salvaged

d) Reperfusion injury would be minimized

e) Complete infarction of the myocardium at risk


Four months following a dental surgery a 65-year old man develops flu-like

symptoms with fatigue and weight loss. Chest auscultation reveals an

aortic murmur and Echocardiography shows calcific stenosis of the aortic

valve with large vegetations. A blood culture in this patient is likely to be

positive for:

a) Staphylococcus aureus

b) Group B beta hemolytic streptococci

c) Staphylococcus epidermidis

d) Streptococcus viridans

e) Gram negative bacilli


Bone marrow examination of a patient presenting with severe anemia and

jaundice reveals increased number of normoblasts and a reticulocyte count

of 10%. Bilirubin is 8mg/dl and predominantly unconjugated. If the patient

has no hemoglobinuria or hemoglobinemia, what is the most likely cause of


a) Iron deficiency

b) Cobalamine deficiency

c) Intravascular hemolysis

d) Aplastic anemia

e) Extravascular hemolysis


A traveller from Europe is given antimalarial prophylaxis before he

travelled to Pakistan. He presented to a local hospital with lethargy, anemia

and jaundice. Urine routine examination shows hemoglobinuria. A

peripheral smear shows bite cells and membrane-bound precipitates in red

blood cells which stain as dark inclusions on cresyl violet staining. What

enzyme deficiency is likely to be present in this patient:

a) Phosphofructokinase

b) Glucose 6-phosphate dehydrogenase (G6PD)

c) Alpha 1 antitrypsin

d) Glutathione reductase

e) Glutathione peroxidase


A patient presents with weakness, pallor and repeated episodes of fever

and chills 2 months after he recovered from an episode of viral hepatitis.

Blood CP shows pancytopenia. Bone marrow biopsy shows fatty infiltration

of marrow with marked hypocellularity. The findings are most consistent

with a diagnosis of:

a) Myelodysplastic syndrome

b) Acute leukemia

c) Aplastic anemia

d) Non Hodgkin's Lymphoma

e) Chronic leukemia


A 30-year-old female presenting with insidious onset of shortness of breath

associated with dry cough is found to have bilateral hilar lymphadenopathy

with pulmonary infiltrates. Bronchoscopic biopsy shows non-caseating

granulomas with giant cells containing Schaumann bodies and asteroid

bodies. These features are most consistent with a diagnosis of:

a) Tuberculosis

b) Silicosis

c) Interstitial pneumonitis

d) Sarcoidosis

e) Fungal infection


A 45-year-old woman presents with anemia and fatiguability. She has mild

jaundice on clinical examination. Blood CP shows a raised MCV of 105fl and

leucopenia. Peripheral smear shows macrovalocytes and hypersegmented

neutrophils. Schilling test for absorption of orally administered cobalamin is

positive. What is a gastric biopsy from this patient likely to show:

a) H. pylori infection

b) Chronic non specific gastritis

c) Peptic ulceration

d) Hypertrophic gastritis

e) Atrophy of fundic glands with intestinalization


A 40-year-old male develops chronic diarrhea following antibiotic therapy

for enterocolitis. Sigmoidoscopy reveals plaques of yellow fibrin and

inflammatory debris adherent to colonic mucosa. Histologic examination of

biopsy material reveals a plaque-like adhesion of fibrinopurulent necrotic

debris and mucous to damaged colonic mucosa. Diagnosis is confirmed by

finding of which bacterial toxin in stool:

a) Shiga toxin

b) C. difficile cytotoxin

c) Vibrio cholera enterotoxin

d) Campylobacter enterotoxin

e) E. coli enterotoxin

Q.10 A 30-year-old female has attacks of bloody mucoid diarrhea lasting a week

to 10 days with symptom free intervals of 3-4 months in between.

Sigmoidoscopy shows uninterrupted mucosal inflammation from rectum to

splenic flexure. Biopsy material shows mucosal ulceration, cryptitis and

crypt abscess formation, pseudopolyps and mild epithelial dysplasia. No

granulomas are seen. What morphologic feature is the most important

predictor of long-term prognosis of this patient:

a) Absence of granulomas

b) Ulceration

c) Cryptitis

d) Dysplasia

e) Pseudopolyps

This post was last modified on 04 December 2021