Download MBBS Anatomy PPT 3 Embryo Urinary System Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) Human Anatomy ppt lectures Topic 3 Embryo Urinary System Notes. - anatomy ppt free download human anatomy ppt lectures, medicine notes ppt, anatomy handwritten notes pdf, mbbs 1st year anatomy notes pdf download, best anatomy notes pdf, human anatomy notes pdf, anatomy easy notes pdf, anatomy notes online, anatomy short notes, Anatomy ppt, Powerpoint Presentations and lecture notes.




Intermediate Mesoderm Forms Much

of the Urogenital System

Mesoderm in the Chick Embryo

Lateral Rotation




Hindgut with allantois

Hind Gut-Cloaca

Urorectal Septum

Urorectal Septum




Urorectal Septum

Urorectal Septal Defects and

Imperforate Anus

Kidney Systems

Pronephric Kidney







Collecting System Forms from the

Ureteric Bud


The Ureteric Bud Induces the Metanephric

Blastema to Form Filtration Units




MCQ

When does the metanephros become
functional?
(A) At week 3 of development
(B) At week 4 of development
(C) At week 10 of development
(D) Just before birth
(E) Just after birth

Molecular Regulation of Kidney

Development


Renal Tumors and Defects

? Wilms' tumor is a cancer of the kidneys that

usually affects children by 5 years of age but may

also occur in the fetus.

? Wilms' tumor is due to mutations in the WT1

gene on 11p13, and it may be associated with

other abnormalities and syndromes.

? For example, WAGR syndrome is characterized by

aniridia, Genitourinary abnormalities, and Wilms'

tumor and mental retardation

? Denys-Drash syndrome consists of renal failure,

pseudohermaphrodism, and Wilms' tumor.

Renal dysplasias and agenesis

? Multicystic dysplastic kidney in which

numerous ducts are surrounded by

undifferentiated cells.

? Nephrons fail to develop
? ureteric bud fails to branch,
? the collecting ducts never form.
In some cases, these defects cause involution of

the kidneys and renal agenesis

Position of the Kidney

? The kidney, initially in the pelvic region, later shifts to a

more cranial position in the abdomen.

This ascent of the kidney is caused by
? diminution of body curvature
? by growth of the body in the lumbar and sacral regions
In the pelvis, the metanephros receives its arterial

supply from a pelvic branch of the aorta. During its ascent

to the abdominal level, it is vascularized by arteries that

originate from the aorta at continuously higher levels.

The lower vessels usually degenerate, but some may

remain.




Kidneys Develop in the Pelvic Region

Ascent of the Kidneys

Rotation Of Kidney


Developmental anomalies of the kidney

A. Renal agenesis :
? Failure of one or both kidneys to develop
? Bilateral: rare, associated with other

congenital anomalies, incompatible with life

? Unilateral: common (one in 4,000 infants,

more boys than girls) , asymptomatic;

? Other kidney enlarges to compensate#Absent

ipsilateral renal artery

Pelvic and Horseshoe Kidneys

Developmental Anamoly-

Fused Kidneys

Developmental Anamoly- Disc Kidney


In congenital polycystic kidney disease

? It may be inherited as an autosomal recessive or autosomal

dominant disorder or may be caused by other factors.

Autosomal recessive polycystic kidney disease
? which occurs in 1/5,000 births, is a progressive disorder in

which cysts form from collecting ducts. The kidneys

become very large, and renal failure occurs in infancy or

childhood.

In autosomal dominant polycystic kidney disease,

cysts form from all segments of the nephron and usually do

not cause renal failure until adulthood. The autosomal

dominant disease is more common (1/500 to 1/1,000 births)

but less progressive than the autosomal recessive disease.

Polycystic Kidney

Recessive form: 1:5000; cysts from collecting tubules; renal failure in infancy

Dominant form: 1:500-1000: cysts from anywhere; renal failure in adulthood

Duplications of the Ureters

Kidneys With Double Ureter


Duplication of the ureter

? results from early splitting of the ureteric bud
? Splitting may be partial or complete, and metanephric

tissue may be divided into two parts, each with its own

renal pelvis and ureter. More frequently, however, the two

parts have a number of lobes in common as a result of

intermingling of collecting tubules.

? In rare cases, one ureter opens into the bladder, and the

other is ectopic, entering the vagina, urethra, or vestibule .

This abnormality results from development of two ureteric

buds. One of the buds usually has a normal position,

whereas the abnormal bud moves down together with the

mesonephric duct. Thus it has a low, abnormal entrance in

the bladder, urethra, vagina, or epididymal region.

Possible Positions for Ectopic Ureters

MCQ

During surgery for a benign cyst on the kidney, the

surgeon notes that the patient's right kidney has two

ureters and two renal pelves. This malformation is
? (A) an abnormal division of the pronephros
? (B) an abnormal division of the

mesonephros
? (C) formation of an extra mass of intermediate

mesoderm
? (D) a premature division of the metanephric

blastema
? (E) a premature division of the ureteric bud
MCQ

? The transitional epithelium lining the urinary
bladder is derived from
? (A) ectoderm
? (B) endoderm
? (C) mesoderm
? (D) endoderm and mesoderm
? (E) neural crest cells

MCQ

The transitional epithelium lining the ureter is

derived from
? (A) ectoderm
? (B) endoderm
? (C) mesoderm
? (D) endoderm and mesoderm
? (E) neural crest cells

MCQ

The podocytes of Bowman's capsule are derived

from
? (A) ectoderm
? (B) endoderm
? (C) mesoderm
? (D) endoderm and mesoderm
? (E) neural crest cells

MCQ

The proximal convoluted tubules of the

definitive adult kidney are derived from the
? (A) ureteric bud
? (B) metanephric vesicle
? (C) mesonephric duct
? (D) mesonephric tubules
? (E) pronephric tubules


Floating kidney- Dietl's Crisis

Bladder Development

Final Position of the Ureters and

Mesonephric Duct (Vas Deferens)


Bladder Development: Incorporation

of the Mesonephric Duct

Urachal Abnormalities

MCQ

The trigone on the posterior wall of the urinary

bladder is formed by the
? (A) incorporation of the lower end of the

mesonephric ducts
? (B) incorporation of the lower end of the

pronephric ducts
? (C) incorporation of the metanephric

blastema
? (D) incorporation of the mesonephric tubules
? (E) incorporation of the pronephric tubules


Ectopic Vesicae


MCQ

Immediately after birth of a boy, a moist, red

protrusion of tissue is noted just superior to his

pubic symphysis. After observation, urine drainage

is noted from the upper lateral corners of this tissue

mass. What is the diagnosis?
? (A) Pelvic kidney
? (B) Horseshoe kidney
? (C) Polycystic disease of the kidney
? (D) Urachal cyst
? (E) Exstrophy of the bladder

MCQ

A urachal cyst is a remnant of the
? (A) urogenital sinus
? (B) urogenital ridge
? (C) cloaca
? (D) allantois
? (E) mesonephric duc



This post was last modified on 05 April 2022