Download RGUHS B.Pharm 2018 January 4th Year 1875 Biopharmaceutics And Pharmacokinetics Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) B.Pharm (Bachelor of Pharmacy) 2018 January 4th Year 1875 Biopharmaceutics And Pharmacokinetics Previous Question Paper

Rajiv Gandhi University of Health Sciences, Karnataka

IV Year B.Pharm Degree Examination ? JAN-2019

Time: Three Hours



Max. Marks: 80 Marks

BIOPHARMACEUTICS AND PHARMACOKINETICS

(OS & RS)

Q.P. CODE: 1875

Your answers should be specific to the questions asked

Draw neat labeled diagrams wherever necessary

LONG ESSAYS (Answer any Two)

2 x 10 = 20 Marks

1.

Explain the various mechanism of drug absorption.

2.

Define drug distribution, name the various factors influencing drug distribution and write a

note on Blood Brain Barrier.

3.

Explain the method of residuals procedure in determining absorption rate constant with its

applications and limitations.

SHORT ESSAYS (Answer any Eight)

8 x 5 = 40 Marks

4.

Write a brief note on dialysis and haemoperfusion.

5.

Effect of gastric emptying and intestinal transit time on drug adsorption

6.

Write a note on Pre-systemic metabolism of drugs.

7.

Write a brief note on Two compartment model.

8.

Explain Darson-Danniel theory in explaining cell membrane.

9.

Dosage regimen adjustment in renal failure

10.

Influence of process variables on drug absorption

11.

Explain trapezoidal method in estimating bioavailability.

12.

Name the Pharmacokinetic parameters with their final mathematical equations for one
compartment Kinetics with iv bolus administration.

13.

Write a note on renal Clearance.

SHORT ANSWERS

10 x 2 = 20 Marks

14.

Effect of ionization on drug absorption

15.

Non renal clearance

16.

For which drugs rapid gastric emptying is desirable

17.

Define transcellular and paracellular drug absorption mechanisms.

18.

Name the rate limiting steps in the absorption of lipophillic and hydrophilic drugs.

19.

Limitations of one compartment model

20.

Drug metabolizing organs

21.

Onset time and onset of action

22.

Binding of drugs to globulins

23.

Absolute bioavailability and Relative bioavailability

*****