Max. Marks: 80 Marks
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BIOPHARMACEUTICS AND PHARMACOKINETICS
(OS & RS)
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Q.P. CODE: 1875Your answers should be specific to the questions asked
Draw neat labeled diagrams wherever necessary
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LONG ESSAYS (Answer any Two)
2 x 10 = 20 Marks
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1.Explain the various mechanism of drug absorption.
2.
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Define drug distribution, name the various factors influencing drug distribution and write a
note on Blood Brain Barrier.
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3.Explain the method of residuals procedure in determining absorption rate constant with its
applications and limitations.
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SHORT ESSAYS (Answer any Eight)
8 x 5 = 40 Marks
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4.Write a brief note on dialysis and haemoperfusion.
5.
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Effect of gastric emptying and intestinal transit time on drug adsorption
6.
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Write a note on Pre-systemic metabolism of drugs.7.
Write a brief note on Two compartment model.
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8.
Explain Darson-Danniel theory in explaining cell membrane.
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9.Dosage regimen adjustment in renal failure
10.
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Influence of process variables on drug absorption
11.
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Explain trapezoidal method in estimating bioavailability.12.
Name the Pharmacokinetic parameters with their final mathematical equations for one
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compartment Kinetics with iv bolus administration.13.
Write a note on renal Clearance.
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SHORT ANSWERS
10 x 2 = 20 Marks
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14.Effect of ionization on drug absorption
15.
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Non renal clearance
16.
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For which drugs rapid gastric emptying is desirable17.
Define transcellular and paracellular drug absorption mechanisms.
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18.
Name the rate limiting steps in the absorption of lipophillic and hydrophilic drugs.
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19.Limitations of one compartment model
20.
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Drug metabolizing organs
21.
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Onset time and onset of action22.
Binding of drugs to globulins
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23.
Absolute bioavailability and Relative bioavailability
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