Time: Three Hours
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Max. Marks: 80 Marks
MEDICINAL CHEMISTRY - II
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(Revised Scheme - 2)Q.P. CODE: 1969
Your answers should be specific to the questions asked
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Draw neat labeled diagrams wherever necessary
LONG ESSAYS (Answer any Two)
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2 x 10 = 20 Marks1.
Classify antiarrhythmic drugs with relevant examples and structures. Add a note on
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antianginal agents and antihyperlipidemic agents.2.
Define and classify antibiotics. Explain the chemistry and SAR of tetracyclines.
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3.
Define and classify antimalarial drugs. Write the synthesis of Chloroquine and
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pyrimethamine.SHORT ESSAYS (Answer any Eight)
8 x 5 = 40 Marks
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4.
Write the structure and mechanism of action of Methotrexate.
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5.Give an account of loop diuretics.
6.
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Explain the SAR of thiazide diuretics.
7.
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Write a note on chemistry and SAR of sulfonamides.8.
Give an account of oral hypoglycaemics. Write the synthesis of chlorpropamide.
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9.
Write the synthesis of metronidazole and dapsone.
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10.Enlist various antitubercular drugs. Write the synthesis of INH.
11.
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Give an account of anthelemintic agents.
12.
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Explain the significance of prodrugs and combinatorial chemistry in drug design.13.
Write the structure and uses of the following: i) Clavulanic acid ii) Clotrimazole
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iii) Caffeine iv) Ampicillin.
SHORT ANSWERS
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10 x 2 = 20 Marks14.
Outline the synthesis and uses of Warfarin.
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15.
Give examples and structures for antithyroid drugs.
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16.Write the structure and uses of spironolactone.
17.
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Name two antifungal antibiotics with their specific uses.
18.
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Write the structure and uses of benzyl benzoate.19.
Write the structure and uses of Erythromycin.
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20.
Give the mechanism of action and uses of Pyrimethamine.
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21.Write structures of acetazolamide and chloramphenicol.
22.
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Define sclerosing agent with example.
23.
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Write the synthesis and uses of Tolnaftate.*****