[Max. marks : 70]
Medicinal Chemistry II
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(Revised Scheme ? 3)
QP Code: 2619
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Your answers should be specific to the questions asked.Draw neat labeled diagrams wherever necessary.
LONG ESSAY (Answer any two)
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2 X 10 = 20 Marks
1.
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Classify sulphonamides. Give the SAR and chemistry of sulphonamides. Write the synthesis ofsulphamethoxazole
2.
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Classify anti-hypertensive agents with examples and give their mechanism of action. Outline the
synthesis of Nitrofurantoin.
3. What are anti-malarial agents classify them with examples. Give their mechanism of action and
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outline the synthesis of pamaquine
SHORT ESSAY (Answer any six)
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6 X 5 = 30 Marks4.
Write the synthesis, medicinal uses and mode of action of thiabendazole
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5.
What are anti neo-plastic agents? Discuss hormones as anti-neoplastic agents
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6.Write a short note on computer aided drug design and combitorial chemistry
7.
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Discuss the chemistry of macrolide antibiotics giving their uses and side effects
8.
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What are calcium channel blockers? Describe their effects on cardiovascular system9.
Write a note on carbonic acid anhydrase inhibitors. Give their structure and uses.
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10. Explain the SAR of tetracylines.
11. Write the structure and medicinal uses of any four antiprotozoal drugs.
SHORT ANSWERS
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10 X 2 = 20 Marks
12.
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Give the synthesis and medicinal uses of ciprofloxacin13.
Give the structure and mechanism of action of lomustine
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14.
Write the structure and uses of any two anti-thyroid drugs.
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15.What are potassium sparing diuretics? Give the structure of triampterene.
16.
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What are monolactam antibiotics? Give the structure and medicinal uses of aztreonam.
17.
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Give examples of cationic surfactants with their specific uses.18.
What is lead molecule? Give examples.
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19.
Give the synthesis of Furazolidone
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20.Outline the synthesis of warfarin
21.
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Preservatives used in ocular products
* * * * *
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