Download RGUHS B.Pharm 2018 January 4th Year 2623 Pharmacy Practice II Rs 3 Question Paper

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Time: Three Hours



Max. Marks: 70 Marks

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PHARMACY PRACTICE ? II (RS-3)

a. Pharmacokinetics and Therapeutic Drug Monitoring

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Q.P. CODE: 2623

Your answers should be specific to the questions asked

Draw neat labeled diagrams wherever necessary

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LONG ESSAYS (Answer any Two)

2 x 10 = 20 Marks

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1.

Describe in detail about estimation of elimination kinetics of a drug by urinary excretion data.

2.

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Write a note on two-compartment open model after IV bolus administration.

3.

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Define protein binding of drugs. Discuss the kinetics involved in protein binding

SHORT ESSAYS (Answer any Six)

6 x 5 = 30 Marks

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4.

Differentiate between clearance and extraction ratio. Describe the significance of hepatic
clearance.

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5.

Describe AUC and its determination

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6.

Write a note on mono exponential decline

7.

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Physiological factors related to protein binding

8.

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Dosage adjustment in hepatic and renal impairment

9.

What is dosage regimen? Write the principle underlying in dosage regimen design

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10.

Write a note on drug dosing in pediatrics.

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11.

TDM of Methotrexate

SHORT ANSWERS

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10 x 2 = 20 Marks

12.

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Write any two applications of TDM

13.

Organization of TDM

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14.

Non-renal clearance

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15.

Advantages of compartment model

16.

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Name the factors affecting drug distribution

17.

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Concept of loading dose and its significance

18.

Biological half life

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19.

Define pharmacokinetics

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20.

Cmax and Tmax

21.

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What is drug accumulation?

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