[Max. marks : 70]
Medicinal Chemistry - II
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(RS ? 4)
QP Code: 2644
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Your answers should be specific to the questions asked.Draw neat labeled diagrams wherever necessary.
LONG ESSAYS (Answer any Two)
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2 X 10 = 20 Marks
1.
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What are antibiotics? Discuss the SAR & MOA of tetracyclines.2.
Classify antihypertensive agents? Write the MOA of calcium channels blockers & beta blockers with
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example.3.
Classify cephalosporins with examples. Write the structure and uses any two cephalosporins.
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SHORT ESSAYS (Answer any Six)
6 X 5 = 30 Marks
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4.What are anthelmintics? Write the synthesis of thiabendazole and albendazole.
5.
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What are antifungal antibiotics? Explain their mechanism of action.
6.
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Give the mechanism of action of sulphonamides. Write the structure and uses of Phthalylsulphathiazole and sulphadiazine.
7.
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What are anti-malarial drugs? Explain the life cycle of malaria.
8.
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Discus the mechanism of action of mercaptopurine and busulfan.9.
Define angina pectoris? Write the MOA of Antianginal agents? Write the structure and uses of
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nitroglycerine.10. Classify the alkylating agents with examples. Outline the synthesis of chlorambucil.
11. What are antiviral drugs? Classify them with examples.
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SHORT ANSWERS10 X 2 = 20 Marks
12.
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Write the structure of one prodrug and its active metabolites.
13.
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Mention the steric paramaters used in QSAR.14.
Give the structure and uses of ciprofloxacin.
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15.
What are antiviral agents? Give any two examples.
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16.Name any two sulfonamides used in the treatment of burn therapy.
17.
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What are calcium channel blockers? Give examples.
18.
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Name any two biguanides used in the treatment of hyperglycemia.19.
Give examples for synthetic estrogens.
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20.
Write the structure and uses of spironolactone.
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21.Mechanism of Acetazolamide
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