Download OU B.Sc 2019 June-July 6th and 7th Semester 3301 Chemistry Question Paper

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Code No. 3301/E

FACULTY OF SCIENCE

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B.Sc. VI-Semester (CBCS) Examination, May / June 2019

Subject : Chemistry

Paper — VII (A) (DSE E-1) : Medicinal Chemistry

Time : 3 Hours Max. Marks: 60

PART - A (5 x 3 = 15 Marks)

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(Short Answer Type)

Note : Answer any FIVE of the following questions.

1. Define Pharmacology, Pharmacodynamics and Pharmacophore.
2. Give the generic name and trade name for any two drugs.
3. Explain briefly the role of OH group and double bond in drug-receptor complex formation.

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4. What are agonists and antagonists? Give examples.
5. What are anti-diabetic and antipyretic drugs? Give one example for each.
6. Write the synthesis and therapeutic activity of Dapson.
7. What are hormones? Give two examples.
8. What are micronutrients? How Na and Ca are helpful for good health?

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PART — B (45 Marks)

(Essay Answer Type)

Note: Answer ALL from the questions.

1. (a) (i) Give the classification of drugs based on therapeutic activity with examples. (ii) Discuss about routes-of administration of drugs
   OR
   

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   (b) (i) Describe briefly Phase I and Phase II reactions in metabolism of drugs. (ii) Write a short note on metabolites and antimetabolites.
2. (a) (i) Write the mechanism of enzyme catalyzed reactions. (ii) Discuss about different types of enzyme inhibition.
   OR
   (b) (i) Explain the factors affecting the enzymatic reactions. (ii) Explain the structure activity relationship studies of Sulfonamides.
3. (a) Write the synthesis and therapeutic activity of Omeprazole, Benzocaine and Cisplatin.
   

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   OR
   (b) (i) Discuss about general and local anesthetics. (ii) Write the semi synthesis and therapeutic activity of Penicillin — G.
4. (a) (i) What are adrenergic drugs? Write the structure and therapeutic activity of Salbutamol. (ii) Discuss about the sources and deficiency disorder of water soluble vitamins.
   OR
   (b) (i) Discuss about the sources and deficiency disorder of A, D, E vitamins. (ii) Discuss about the drug interaction of Pyridoxamine and Levodopa.

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