Cytology slides (for spotting)
1. Fibroadenoma
2. Granulomatous reaction lymph node
3. Squamous cell carcinoma sputum
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4. Cervical smear Invasive squamous cell carcinoma5. Adenocarcinoma in body fluids
6. Papillary carcinoma thyroid
Recommended Textbooks
Pathologic Basis of Disease-Robbins and Cotran 7th edition
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Text Book of Pathology-Harsh Mohan 6th editionGeneral and Systematic Pathology-5th edition-JCE Underwood
Haematology-G E De Gruchy
Text and Practical Haematology MBBS-Tejinder singh
Manual of Basic Techniques for Health laboratory-WHO
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PHARMACOLOGYI. Goal:
The broad goal of teaching Pharmacology to undergraduates is
? To impart knowledge, skills and attitudes to the students so that they can prescribe drugs
safely, effectively and maintain competency in professional life.
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? To inculcate in them a rational and scientific basis of therapeutics.II. Educational Objectives. a)
Knowledge
At the end of the course, the learner shall be able to
? describe the pharmacokinetics and pharmacodynamics of essential and commonly used
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drugs? list the indications, contraindications, interactions and adverse reactions of commonly
used drugs
? indicate the use of appropriate drug in a particular disease with consideration of its cost,
efficacy and safety for individual needs, and mass therapy under national health
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programmes? integrate the list the drugs of addiction and recommend the management
? classify environmental and occupational pollutants and state the management issues
? explain pharmacological basis of prescribing drugs in special medical situations such as
pregnancy, lactation, infancy, old age, renal and hepatic failure
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? explain the concept of rational drug therapy in clinical pharmacology with special focusto usage of antimicrobial drugs.
? prescribe drugs for the control of fertility and be aware of the effects of drugs on the foetus.
? describe the clinical presentation and management of common poisoning including the
bites and stings.
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98? state the principles underlying the concept of `Essential Drugs'
? evaluate the ethics and modalities involved in the development and introduction of
new drugs
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? understand principles of Evidence based Medicine? understand the principles of pharmacoeconomics
(b) Psychomotor Skills:
At the end of the course, the learner shall be able to:
? prescribe drugs for common ailments
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? identify adverse reactions and interactions of commonly used drugs? interpret the data of experiments designed for the study of effects of drugs and
bioassays which are observed during the study
? scan information on common pharmaceutical preparations and critically evaluate
drug formulations
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? load the required dose of medicines accurately in hypodermic syringes; injectmedicines by the intradermal, subcutaneous, intramuscular and intravenous routes using
aseptic techniques.
? Set-up an intravenous drip and adjust the drip rate according to required dosage.
? calculate the drug dosage using appropriate formulae for an individual patient.
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? administer the required dose of different drug formulations using appropriate devicesand techniques (e.g., hypodermic syringes, inhalers, transdermal patches etc.)
? Advice and interpret the therapeutic monitoring reports of important drugs
? recognize and report adverse drug reactions to suitable authorities.
? analyse critically, drug promotional literature for proprietary preparations in terms of
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(a) Pharmacological actions of their ingredients(b) Claims of pharmaceutical companies
(c) Economics of use
(d) Rational or irrational nature of fixed dose drug combinations.
? retrieve drug information from appropriate sources especially electronic resources
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(c) Attitudes & Communication skills:At the end of the course, the learner shall be able to
? communicate with patients regarding proper use of drug
? take adequate precaution during prescribing drug(s)
? understand the legal aspects of prescription
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? counsel patients for compliance? take adequate care to write prescriptions legibly
? understand rationality of polypharmacy
? update themselves regarding recent advances
- Basic Clinical communication skills
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Examples of good and poor communication as Role Play - affecting rapport withpatient and family, therapeutic relationship, trust, diagnosis and management. The
stages of grief as described by Elisabeth Kubler Ross
(d) Integration
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Practical knowledge of rational use of drugs in clinical practice will be acquired through
integrated teaching vertically with pre-clinical & clinical subjects and horizontally with
other para-clinical subjects.
DETAILED SYLLABUS
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1. Period of training: 3rd, 4th & 5th Semester2. Duration of training: one and a half years
3. Eligibility: Must have cleared Phase I (Anatomy, Physiology, Biochemistry)
4. Time available for teaching: 300 hours
Lectures: 125 hours Practicals: 75 hours
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Innovative sessions & Internal Assessments: 100 hoursDETAILS OF LECTURES Topic Time (hours) Part I (Drug Oriented teaching)
1. General Pharmacology and basic concepts of clinical Pharmacology
16 hours
? Introduction ? definition, scope, various branches, drug nomenclature, orphan drugs
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? Mechanism of drug action /Pharmacodynamics (Receptor/Molecular mechanism is desirable to know)
? Scope & relevance of clinical pharmacology
? Routes of administration of drugs, new drug delivery system.
? Pharmacokinetics ? Absorption, distribution, metabolism and excretion.
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? Factors modifying drug action and drug dosage? Drug interactions and pharmacogenomics
? Adverse drug reactions and Pharmacovigilance; Therapeutic drug monitoring and
adherence
? Essential drugs and fixed drug combination including pharmacoeconomics
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? Rational use of drugs2. Autonomic nervous system
12 hours
? Cholinergic neurotransmission and cholinergic drugs
? Anticholinergics
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? Adrenergic neurotransmission and adrenergic drugs? Antiadrenergic drugs Skeletal muscle relaxants NO, VIP (self-study)
3 Autacoids and related drugs
3 hours
Histamine receptor antagonists, their pharmacological actions, indications, adverse
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effects and precautionsPharmacology of drugs on prostaglandins and leukotrienes
5HT receptors and their antagonists including treatment of migraine
4 Central nervous system
24 hours
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Drugs used in epilepsy and neuropathic pain ; selection of appropriate drug for various100
types of epilepsy and adverse drug effects
Sedative ? hypnotics used currently in clinical practice, indications contraindications, adverse
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effects, drug interactionsOpioid analgesics: Pharmacological actions, indications, contraindications adverse effects
and drug interactions of commonly used analgesics
NSAIDS: Pharmacological action, indications, contraindications, adverse effects and drug
interactions of commonly used drugs. WHO Analgesic ladderLadder Drugs and Emphasise
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on practical application of NSAIDs, weak and strong opioids.Drug used in the treatment of parkinson's disease: anticholinergic agents, dopamine agonists,
MAOI, COMTI: Their indications, contraindications, adverse effects and drug interactions.
Disease modifying agents in the treatment of rheumatoid arthritis.
Pharmacology of ethanol and methanol poisoning
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Agents used in the treatment of gout (acute and chronic)Antidepressants use in neuropathic pain
Drugs of addiction abuse and dependence (self-study)
Drugs in manic depressive illness and psychosis General
anaesthetics; cardinal features, merits and
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demerits of commonly used anaesthetics ,drug interactionsPreanaesthetic agents; uses, indications, contraindications adverse effects and drug
interactions.
Local anaesthetic agents: Pharmacological basis, adverse drug reactions, indications and
complications of spinal anaesthesia
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Adjuvant analgesics ? and use in chronic painDrugs for treatment of Alzheimer's disease and cognitive enhancers ? (seminar )
5 Cardiovascular System
15 hours
Anti-hypertensive drugs: MOA; adverse drug reactions drug interactions and basis of
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combining commonly used drugsPharmacology of calcium channel blockers Drugs
affecting Renin-Angiotensin system Approaches to
treatment of myocardial infarction. Drug used in
treatment of angina pectoris.
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Drug treatment of peripheral vascular disease (self-study)Management of pain in PV diseases Pharmacology of vasodilators
and cardiac glycosides; usage in CHF
Treatment of Paroxysmal supraventricular tachycardia, atrial dysrhythmias, sudden cardiac
arrest and ventricular filbrillation.
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Diuretics: Mechanism of action, pattern of electrolyte excretion under their influence, shortterm side effects and long term complications of diuretic therapy, therapeutic uses of
diuretics; antidiuretics.
6. Drugs affecting blood and blood formation
6 hours
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Anticoagulants: MOA of heparin and oral anticoagulants indications, monitoring of therapyand treatment of bleeding due to their overdose, drug interactions.
Drugs inhibiting platelet aggregations, their indications and precaution for their use
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Antianaemic drugs (seminar)Treatment of shock (seminar)
Fibrinolytics and antifibrinolytics: indications, adverse reactions.
Hypolipidemics: MOA, adverse reactions and indications
7. Respiratory system
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2 hours? Drug use in treatment of bronchial asthma
? Antitussives, expectorants & mucolytics (seminar)
8. GIT
3 hours
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? Pharmacotherapy of peptic ulcer: MOA, adverse drug reactions, contraindication andprecautions
Antiemetics: MOA, uses, side effects.
Drug used in ulcerative colitis and irritable bowel
syndrome Management of constipation and diarrhoea
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(seminar)9. Drugs acting on Endocrine system
9 hours
?Thyroid hormones and antithyroid drugs: pharmacological action, indications,
contraindications and side effects
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?Drugs use for pharmacotherapy of diabetes mellitus, mechanism of actions,contraindications, precautions during the use and side effects. Management of iatrogenic
hypoglycemia and diabetic ketoacidosis.
? Sex hormones, their analogues and antagonists, uses in replacements
and pharmacotherapy. Outlining the rational for such use, C/l and side
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effects.? Pharmacological approaches to contraception, side effects, precautions during use and C/I.
? Uterine relaxants, and uterine stimulants, indications, side effects, C/I
? Hormones of adrenal cortex, their synthetic analogues, pharmacological actions,
therapeutic uses, precautions, side effects and contraindications. Hormones and drugs
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affecting calcium metabolism, therapeutic indications, contraindications and side effects? Drugs used in the treatment of infertility (self-study)
10. Chemotherapy
17 hours
? General principals of chemotherapy, rational use of antimicrobial agents, indications
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for prophylactic and combined uses of antimicrobials including pre and probiotics? Chemotherapeutic agents: penicillins, cephalosporins, aminoglycosides, broad
spectrum antimicrobial agents, quinolones, sulphonamides macrolides and other newer
drugs: their mechanism of actions, s/e, indications, resistance, and drug
interactions.Drugs used for the treatment and prevention of infections ? examples
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Tuberculosis, Leprosy, Malaria, Amoebiasis and other Protozoal infections, Fungalinfections, Viral infections including HIV, STD, Helminthiasis, Leptospirosis etc.
? Antiseptics, disinfectants and their use based on their pharmacological properties.
(Seminar) Anticancer drugs, mechanism of action, indications, s/e, C/I, Precautions ,
Pharmaco-economics.
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102Toxicology
General principles of treatment of poisoning
Management of overdosage with commonly used therapeutic agents
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Heavy metal poisoning and heavy metal antagonists (seminar)Miscellaneous
Vaccines (self-study)
Drugs modulating Immune system (seminar)
Vitamins, Nutritional supplement (self study)
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Gene therapy (seminar)Drugs acting on skin & mucus membrane (seminar)
Sports medicine (self-Study)
Antioxidants (self-Study)
Part II (Clinical Pharmacology and Therapeutics)
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National Health programmes like:1. Tuberculosis
2. Leprosy
3. HIV
4. Malaria
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5. Syphilis and gonorrhea & STD (seminar)6. Upper and lower respiratory infections;
7. OCP
8. Filariasis
9. Anaemia
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10. Diabetes MellitusRationale, regimen, prescription of the medicines and regimens used for national
programs, basic counseling in these scenarios .
Infective/Parasitic conditions
1. Influenza
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2. Urinary Tract infections (seminar)3. Typhoid and other GIT infections
4. Amoebiasis
5. Worm infestations (seminar)
6. Fungal infections
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7. Herpes and Hepatitis, other antiviralsMedical emergencies , Managing a Pain crisis
1. Acute myocardial infarction, acute angina attack, circulatory failure, sudden cardiac
arrest, hypertensive emergencies
2. Acute anaphylaxis and other acute allergic states
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3. Snake bites and insect bites103
4. Acute poisoning and drug overdosage
5. Status epilepticus, febrile convulsions, acute mania
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6. Acute severe asthma, acute rheumatic fever, acute gout7. Acute colicky pains-intestinal,biliary, renal
8. Post-partum haemorrhage, uterine inertia
Other topics
1. Treatment of pain , , Assessment, classification, management, Application of WHO
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Analgesics? as a seminar
2. Treatment of insomnia
3. Treatment of cough
4. Treatment of fever of unknown origin (PUO)
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5. Drugs used in labour6. IV fluids
7. Clinical uses of glucocorticoids
8. P-drug or how to select a drug for a given patient in a given situation
9. Essential drugs
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10. Drug therapy in special situations (pregnancy, lactation, children, geriatrics, renaland hepatic diseases)
Details of Practicals
1. Dosage forms Oral, Parenteral, Topical & Others
2. Routes of drug administration, setting up an intravenous drip
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3. Calculation of drug dosage4. Sources of drug information-how to retrieve information
5. ADR monitoring
6. Critical appraisal of drug promotional literature
7. Essentials of Clinical trials
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8. Communicating to patients on the proper use of medication.9. Prescription writing, prescription auditing based on rational drug use and FDC
10. Essential drugs list , National List of Essential drugs for India ? adults, children and why
are those particular drugs included.Controlled drugs amongst the essential list and their
availability.
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11. Use of drugs in pregnancy, lactation, children and elderly12. Use of drugs in liver disease and renal disease
13. Preparation of percentage solution
14. Preparation and use of oral rehydration solution
15. Informed Consent Form (To teach it more as a document of good communication,
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trust and shared planning for care than as a legal requirement. )16. Computer assisted learning (CAL)
17. Experimental pharmacology charts interpretation
18. Drug/drug and Drug/Food interaction.
19. Selection of P-drug
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20. Irrational drug combinations, fallacies of using pre-combined drugs104
Teaching-Learning methods:
Small group discussions, tutorials, project work and seminars. An overlap between
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theory and practical classes will serve to reinforce and complement the two. Points notcovered in theory can be covered during practical classes.
Project work
Each student has to collect data of one clinical case and write it down as project. Topics
for Seminars (2 hours each)
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1. Antianaemic drugs2. Antitussives
3. Shock
4. Alzheimer's disease and cognitive enchancers, neurodegenerative disorders.
5. Anthelmintics
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6. Calcium metabolism7. Dermatology ? drugs acting on skin and mucous membrane
8. UTI & STD
9. Irritable bowel syndrome, ulcerative colitis & Eye disorders
10. Immuno Pharmacology
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11. Laxatives and antidiarrhoeals12. Alcohol
13. Osteoporosis, obesity, genetherapy
14. Heavy metal poisoning and heavy metal antagonists
15. Antiseptics
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16. Superinfection, prophylactic use and misuse of antibiotics17. Using analgesics in patients with poor renal function
18. Management of infections which are to be cared for without antibiotics ? diarroheas,
URTI, Uro-genital
Topics for self-study
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1. Treatment of rhinitis2. Carminatives, digestants & antiflatulents
3. Vitamins and antioxidants
4. Vaccines
5. Drug induced blood dyscrasias
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6. Treatment of vertigo7. Other protozoal infections
8. Drugs in pregnancy and infants.
9. NO, VIP
10. Drugs of addiction
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11. Drug treatment of peripheral vascular disease12. Anterior pituitary hormones
13. Drugs used in the treatment of infertility
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14. Reactive oxygen species15. Speciality based prescriptions and the resultant Polypharmacy ? the new healthcare
issue
Recommended books for undergraduates
1. Essentials of Medical Pharmacology by K.D.Tripathi (Prescribed)
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2. Medical Pharmacology 3rd edition by Dr Padmaja Udaykumar (Prescribed)3. Principles of Pharmacology by H.L.Sharma, K.K.Sharma (Prescribed)
4. Pharmacology and Pharmacotherapeutics. R.S Sathoskar and Bhandarkar (Prescribed)
5. Basic and Clinical Pharmacology Lange publications by Bertram G Katzung (Reference)
6. Pharmacology by HP Rang. M M Dale, J.M Ritter, P.K.Morore (reference)
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7. The Pharmacological Basis of Therapeutics by Goodman & Gilman (reference)Evaluation
Internal Assessment ? 3 sessional examinations
One exam for theory at the end of each semester
The last sessional exam will be model examination (as per University pattern) ?
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theory, Practical and viva voceInternal assessment for theory = 15 marks
Internal Assessment is calculated with following break up
Final theory -Paper I and Paper II = 80 marks
Seminar presentation and post-test = 20 marks
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Project = 10 marksViva voce = 20 marks
Best of first two theory exams out of (n-1) = 20 marks
Total = 150 marks
Internal assessment for theory = 150 / 10 = 15 marks
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Internal assessment for practicals = 15 marksRecord = 5 marks
Practicals = 25marks
Total 25+5= 30/ 2= 15 marks
University examinations marks break up are
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Theory -two papers of 40 marks each - 80 marksPractical - 25 marks
Viva voce - 15 marks
Internal assessment
(Theory-15; practical 15) - 30 marks
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Total - 150 marksPattern of Theory paper for final sessional exam and university exam
There will be 2 papers of 40 marks each. No division of question papers into section A
and section B
Duration is 2 hours/ paper
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106Paper I
(Topics: General Pharmacology, ANS, CVS, blood, diuretics, CNS, autacoids, Respiratory System
I.
Clinical Problem (1) = 5 marks
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I .Structured essay questions (1) = 5 marks
I I.
Short notes (4 x3 = 12 marks)
IV.
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Give reasons for the following (5 x1 = 5)V.
Give two uses and two adverse effects specific to the drug (4 x1= 4)
VI.
Choose the drug and justify (5 x 1 = 5)
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VI .Name two drugs (? x 8 = 4)
Paper II
(Topics: GIT, Hormones, antibiotics, chemotherapy and miscellaneous)
I.
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Clinical problem ( 1) = 5 marksI .
Structured essay questions (1) = 5 marks
I I.
Short notes (4 x3 = 12 marks)
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IV.Give reasons for the following (5 x1 = 5)
V.
Specify the mechanism of action of the following drugs (3 x1 = 3)
VI.
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Specify the spectrum (highly susceptible organism) for the following agents (2x1=2)VI .
Give two uses and two adverse effects specific to the drug (4 x1= 4)
VI I. Name two drugs (? x 8 = 4)
Practicals
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Total marks = 25 marksPractical I -Objective Structured Practical Examination (OSPE)
Response stations -10
Time at each station is 5 minutes.
1. Prescription writing for prescription for common ailments -1 = 2marks
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2. Prescription for special groups ? pregnant woman, children, elderly and patients withrenal or hepatic disease) -1 = 2 marks
3. Exercise on Drug interaction ? 1 = 2 marks
4. Drug dosage calculation -1 = 1 mark
5. Dosage forms -1 = 1 mark
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6. Drugs -3 nos from different: groups = 3 marks7. Device -1 = 1 mark
8. Diagram/Picture of plants or ADR-1 = 1 mark
9. Calculation of percentage solutions (normal saline, 5% dextrose/half normal
saline/others) /ORS procedure) -1 = 1 mark
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10. Sources of drug information? 1 = 1 markTotal = 15 marks
Practical II- (Interactive sessions)
107
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1. Clinical Pharmacology chart ? 1 = 2 marks2. Interpretation of experimental chart -1 = 3 marks
3. Interpretation of data (providing lab: reports) -1 = 1 mark
4. Criticize and rewrite informed consent form ? 1 = 3 marks
5. ADR (clinical problem) -1 = 1 mark
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OR6. Give an irrational prescription with wrong dosage, wrong route, wrong frequency
and inadequate supportive drugs. Exercise to correct the mistakes and form a rational
prescription-1=3marks
OR
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7. Demonstrate route of administration (loading syringe,cleaning,differentroutes IM.IV.SC etc) or demonstrate use of Inhaler or use of eye drops, OC etc)
-1= 3 marks
Total = 10marks
VIVA VOCE
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Total 4 stations each student to be examined by all the fourexaminers Total 15 marks
COMMUNITY MEDICINE
A. VISION
To develop a group of medical graduate who will be proactive in identifying and
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responding to public health challenges the society is facing.B. MISSION
To bring out a group of Medical Graduates who can practice the science of medicine with
Social responsibility and social accountability and provide cost effective, value based
comprehensive health care.
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C. GOALTo equip the students to function efficiently and effectively as first level physicians in the
community in accordance with the committed vision and mission of community
medicine.
D. DEPARTMENTAL OBJECTIVES
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D.1. GENERAL OBJECTIVETo train Medical Students with knowledge, attitude and skills required to become
doctors with empathy, and, who can effectively function as healthcare providers,
decision makers, communicators, community leaders and managers in rural and urban
settings.
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D.2. SPECIFIC OBJECTIVESD.2.1. KNOWLEDGE
1. To identify the multi-factorial determinants & dimensions of health and
disease, dynamics of community behaviours and human society
2. To understand the structure and process of the health care delivery system
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108