DZ-4006
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First Year M. B. B. S. Examination
June / July - 2016
Biochemistry: Paper - II
Time: 2 1/2 Hours] [Total Marks: 40
Instructions:
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(1)
? ? ? ? ? ? ?. Fillup strictly the details of signs on your answer book.
Name of the Examination:
First Year M. B. B. S.
Name of the Subject:
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BIOCHEMISTRY: PAPER - 2
Subject Code No.: 4 0 0 6 Section No. (1, 2,...) Nil
1 Short Notes: (2 out of 3) 8
(1) Molecular basis of Sickle cell disease.
(2) Urea cycle
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(3) Replication of DNA.
2 Write in Brief: (4 out of 6) 12
(1) Characteristic of Genetic code.
(2) Hyperuricemia and gout.
(3) Factors affecting enzyme activity.
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(4) Post translation modification
(5) Biochemical basis of scurvy
(6) Polymerase chain reaction.
3 Read Following Case & Answer the Question : 10
A 65 year old male who was unwell for past few days came
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for consultation. He had developed loss of appetite, weakness
malaise and nausea he also reported that his eyes were dark
yellow from last two weeks his urine is turned dark yellow
but colour of the stool is pale. His blood and urine reports
were as follows
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DZ-4006] 1 [Contd...
Blood chemistry
Total bilirubin 10.2 mg% Serum AST 28/IU/L
Indirect bilirubin 1.5 mg% Serum ALT 32 IU/L
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Direct bilirubin 8.7 mg% Serum ALP 220 U/I
APTT - Test : 60 sec APTT - Control : 30 sec
Urine examination
Bile pigment : Present
Urobilinogen : Absent
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Bile salts : Absent
(1) What is the difference between direct and indirect
bilirubin?
(2) Write about different types of jaundice and their causes?
(3) What are enzyme markers for different types of jaundice?
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(4) Give biochemical explanation for abnormal APTT level.
(5) Why bile salts are present in urine in this case
4 Write a justification in 2-3 lines: (5 out of 7) 10
(1) Vitamin B12 and folic acid deficiency can cause
hyperhomocysteinemia
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(2) Blood Buffers act quickly but not permanently.
(3) Phenobarbitone can precipitate acute intermittent
porphyria.
(4) Zwitterion has least buffering and solubility.
(5) Glutathione and NADPH play important role for
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maintain RBC membrane
(6) Biotin is known as anti-egg white injury factor
(7) Glycine does not exhibit optical isomerism
DZ-4006] 2 [600]
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This download link is referred from the post: VNSGU MBBS Last 15 Years 2010-2025 Previous Question Papers (Veer Narmad South Gujarat University)
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