Download MBBS Ophthalmology PPT 43 Posterior Uveitis Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) Ophthalmology PPT 43 Posterior Uveitis Lecture Notes




POSTERIOR UVEITIS

Definition & Classification of Uveitis-
? Inflammation of uveal tract is uveitis.

? CLASSIFICATION:

? I. ANATOMICAL CLASSIFICATION

? II. CLINICAL CLASSIFICATION

? III. ETIOLOGICAL CLASSIFICATION

? IV. PATHOLOGICAL CLASSIFICATION


A. Anatomical Classification ? (IUSG)

International Uveitis Study Group

1) Anterior Uveitis ? Inflammation of iris and anterior

part of ciliary body.

2) Intermediate Uveitis ? Involvement of posterior

part of ciliary body and extreme periphery of retina.

(Pars planitis)

3) Posterior uveitis ? Retinochoroiditis, choroiditis,

retinitis, chorioretinitis

4) Diffuse or pan uveitis ? Involvement of entire uveal

tract

B. Clinical Classification -

? 1) Acute ? sudden symptomatic onset. Persists

for 3 weeks or less.

? 2) Chronic ? Frequently insidious and

asymptomatic. Persists for months or years.

? 3) Recurrent


C. Etiological Classification

? 1) Exogenous-

Introduction of organism into the eye through a perforating

wound or ulcer. Acute iridocyclitis of suppurative type, pan-

ophthalmitis.

? 2) Secondary infection-

Due to direct spread from adjoining structures-

-- Cornea

-- Sclera

-- Retina

D. Pathological Classification

1) Granulomatous

2) Non-granulomatous


POSTERIOR UVEITIS

? Posterior uveitis refers to inflammation of the

choroid (choroiditis).

? Since the outer layers of retina are in close

contact with the choroid and also depend on it

for the nourishment, the choroidal inflammation

almost always involves the adjoining retina and

the resultant lesion is called chorioretinitis.

Clinical types

? I. Suppurative choroiditis (Purulent

inflammation of the choroid)

? I . Non-suppurative choroiditis

? 1. Diffuse choroiditis.

? 2. Disseminated choroiditis.

? 3. Circumscribed/localised/focal choroiditis.

i. Central choroiditis.

i . Juxtacaecal or juxtapapil ary choroiditis.

i i. Anterior peripheral choroiditis.

iv. Equatorial choroiditis.


Symptoms

? 1. Defective vision.

? 2. Photopsia.

? 3. Black spots floating in front of the eyes.

? 4. Metamorphopsia.

? 5. Micropsia

? 6. Macropsia

? 7. Positive scotoma

Signs

? 1. Vitreous opacities

? 2. Features of a patch of choroiditis.

i. In active stage it looks as a pale-yellow or

dirty white raised area with il -defined edges.

This results due to exudation and cellular

infiltration of the choroid which hide the

choroidal vessels. The lesion is typically

deeper to the retinal vessels. The overlying

retina is often cloudy and oedematous.




Signs

? i . In atrophic stage or healed stage, when

active inflammation subsides, the affected area

becomes more sharply defined and delineated

from the rest of the normal area. The involved

area shows white sclera below the atrophic

choroid and black pigmented clumps at the

periphery of the lesion.


Complications

These include extension of the inflammation to

anterior uvea,

complicated cataract,

vitreous degeneration,

macular oedema,

secondary periphlebitis retinae and

retinal detachment.

Treatment

? It is broadly on the lines of anterior uveitis.

? 1. Non-specific therapy: In the form of topical

and systemic steroids.

? 2. Specific treatment is required for the

causative disease.


PURULENT UVEITIS

? Purulent uveitis is suppurative inflammation of

the uveal tract occurring as a result of direct

invasion by the pyogenic organisms.

? Purulent iridocylitis

? Purulent choroiditis

? Endophthalmitis

? Panophthalmitis

ENDOPHTHALMITIS

? Endophthalmitis is defined as an inflammation

of the inner structures of the eyeball i.e., uveal

tissue and retina associated with pouring of

exudates in the vitreous cavity, anterior

chamber and posterior chamber.

? Etiologically endophthalmitis may be infectious

or non-infectious (sterile).


A. Infective endophthalmitis

? Exogenous infections.

? Endogenous or metastatic endophthalmitis.

? Secondary infections from surrounding

structures.

Causative organisms

? 1. Bacterial endophthalmitis.

S. epidermidis and S.aureus,



Streptococci,



Pseudomonas,



Pneumococci,


Cornebacterium.


Propionio bacterium acnes and actinomyces are

gram-positive organisms capable of producing

slow grade endophthalmitis.

? 2. Fungal endophthalmitis is caused by

aspergil us, fusarium, candida etc.

B. Non-infective

(sterile)endophthalmitis

? Sterile endophthalmitis refers to inflammation of

inner structures of eyeball caused by certain

toxins/toxic substances. It occurs in following

situations.

? 1. Postoperative sterile endophthalmitis

? 2. Post-traumatic sterile endophthalmitis

? 3. Intraocular tumour

? 4. Phacoanaphylactic endophthalmitis




Symptoms.

? Acute bacterial endophthalmitis usually

occurs within 7 days of operation and is

characterized by severe ocular pain, redness,

lacrimation, photophobia and marked loss of

vision.

Signs

? Lid swelling

? Conjunctival chemosis and

congestion

? Corneal edema

? Wound gape & necrosis

? Hypopyon

? Iris becomes edematous and

muddy

? Yellow reflex

? IOP may or may not be raised


Treatment

? Intravitreal antibiotics , S/C injections, Topical

fortified antibiotic drops & oral antibiotics.

? Cycloplegics

? Antiglaucoma therapy

? Vitrectomy

PANOPHTHALMITIS

? It is an intense purulent inflammation of the

whole eyeball including the Tenon's capsule.

? Symptoms.

? Severe ocular pain and headache

? Complete loss of vision

? Watering & discharge

? Marked redness and swelling of the eyes


Signs

? Lids swelling.

? Eyeball is slightly proptosed, ocular

movements are limited & painful.

? Ciliary as well as conjunctival

congestion.

? Cornea is cloudy and oedematous.

? Anterior chamber is full of pus.

? Vision is completely lost

? Intraocular pressure is markedly

raised.

? Complications include

? Orbital cellulitis

? Cavernous sinus thrombosis

? Meningitis or encephalitis


Treatment

? 1. Anti-inflammatory and analgesics

? 2. Broad spectrum antibiotics

? 3. Evisceration

Non-suppurative Uveitis

? I. UVEITIS ASSOCIATED WITH CHRONIC

SYSTEMIC BACTERIAL INFECTIONS:

1. Tubercular uveitis

2. Syphilitic uveitis

3. Leprotic uveitis

? UVEITIS ASSOCIATED WITH NONINFECTIOUS

SYSTEMIC DISEASES

1. Uveitis in sarcoidosis

2. Behcet's disease.


Non-suppurative Uveitis

? III. UVEITIS ASSOCIATED WITH ARTHRITIS

1. Uveitis with Ankylosing spondylitis

2. Reiter's syndrome

3. Stil 's disease

? IV. PARASITIC UVEITIS

1. Toxoplasmosis

2. Toxocariasis

3. Onchocerciasis

4. Amoebiasis

Non-suppurative Uveitis

? V. FUNGAL UVEITIS

1. Presumed ocular histoplasmosis syndrome

2. Candidiasis

? VI. VIRAL UVEITIS

1. Herpes simplex uveitis

2. Herpes zoster uveitis

3. Acquired cytomegalovirus uveitis

4. Uveitis in acquired immune deficiency

syndrome (AIDS)


Non-suppurative Uveitis

? VII. LENS INDUCED UVEITIS

1. Phacotoxic uveitis

2. Phacoanaphylactic endophthalmitis

? VIII. TRAUMATIC UVEITIS

? IX. UVEITIS ASSOCIATED WITH MALIGNANT

INTRAOCULAR TUMOURS

Non-suppurative Uveitis

? IDIOPATHIC SPECIFIC UVEITIS SYNDROMES

1. Fuchs' uveitis syndrome

2. Intermediate uveitis (pars planitis)

3. Sympathetic ophthalmitis

4. Glaucomatocyclitic crisis.

5. Vogt-Koyanagi-Harada's syndrome.

6. Bird shot retinochoroidopathy.

7. Acute multifocal placoid pigment

epitheliopathy (AMPPE)

8. Serpiginous choroidopathy.


VOGT-KOYANAGI-HARADA (VKH) SYNDROME

? It is an idiopathic multisystem disorder which includes

cutaneous, neurological and ocular lesions, more

common in Japanese who are usually positive for HLA-

DR4 and DW15.

? Clinical features

? 1. Cutaneous lesions include: alopecia, poliosis and

vitiligo.

? 2. Neurological lesions are in the form of

meningism,encephalopathy, tinnitus, vertigo and

deafness.

? 3. Ocular features are bilateral chronic granulomatous

panuveitis and exudative retinal detachment.

? Treatment. It comprises steroids administered

topically, periocularly and systemically.

SYMPATHETIC OPHTHALMITIS

? It is a rare bilateral granulomatous panuveitis.

? Occurs following penetrating ocular trauma

associated with incarceration of uveal tissue

in the wound.

? The injured eye is called `exciting eye'

and the fellow eye which also develops uveitis

is called `sympathizing eye'.
? A. Predisposing factors

? 1. It almost always follows a penetrating wound.

? 2. Wounds in the ciliary region

? 3. Wounds with incarceration of the iris, ciliary

body or lens capsule are more vulnerable.

? 4. It is more common in children than in adults.

? 5. It does not occur when actual suppuration

develops in the injured eye.

? Dalen-Fuchs' nodules are formed due to

proliferation of the pigment epithelium (of the iris,

ciliary body and choroid) associated with invasion

by the lymphocytes and epitheloid cells.


Clinical picture

? I. Exciting (injured) eye. It shows clinical features of

persistent low grade plastic uveitis, which include

ciliary congestion, lacrimation and tenderness.

? 2. Sympathizing (sound) eye.

It is usually involved after 4-8 weeks of injury in the

other eye. Can occur upto 1 year after injury.

? Retrolental flare is first clinical sign.

? If not prevented loss of sight is inevitable

? Prophylaxis

? Treatment.




Ocular Toxoplasmosis
Clinical features



Unilateral focal chorio-retinitis adjacent to healed

chorioretinal scar



a. Healed scars may be multiple, but usually only

one reactivates at a time.

b. Atypical forms of extensive chorio-retinitis can

occur in immunocompromised individuals.

c. Active chorio-retinitis is yellow-white, slightly

elevated, with a relatively well-defined border.

Clinical features: Intraocular inflammation

a. Iritis. Often granulomatous & may be associated with

ocular hypertension

b. Vitritis. Often intensified over the lesion

c. Vasculitis. Variably present; Often arteritis, but

also periphlebitis and the vasculitis can be remote from

the chorio-retinitis

d. Optic neuritis or neuro-retinitis.




Appropriate Laboratory Testing

1. Conformation of exposure to toxoplasmosis by serum ab. titer;

high sensitivity and low specificity because of high prevalence

of positive antibody titers in general population

2. Determination of toxoplasmosis IgG or IgA titers in aqueous

humor useful in cases with atypical features

3. PCR of aqueous humor for toxoplasmosis DNA useful in older

patients with large lesions or in immunocompromised patients

Risk of congenital infection

Acquired toxoplasmosis infection in a pregnant woman

a. Most severe effects on fetus if acquired during first trimester

b. Risk of transmission greatest if acquired during third trimester

Seroconversion treated with antibiotic therapy

Prenatal treatment reduces fetal effects.




Differential Diagnosis

1. Toxocariasis

2. Cytomegalovirus retinitis

3. Necrotizing herpetic retinitis

4. Syphilis

5. Focal fungal or bacterial infections

6. Intraocular lymphoma

Treatment

Decision to treat based on proximity to macula and

optic nerve, amount of inflammation, and vision

1. Sight-threatening infections almost always treated.

2. Small, peripheral lesions often observed.

3. Infection is self-limited in most cases in healthy patients.


Treatment

1. Pyrimethamine is most common agent combined with

sulfadiazine or triple-sulfa, azithromycin, or clindamycin

Usually given with leukovorin to mitigate hematologic toxicity

2. Trimethoprim-sulfamethoxazole increasing in use combined

with clindamycin for increased efficacy

3. Monotherapy-generally reserved for non-sight-

threatening disease; Doxycycline or minocycline

Anti-inflammatory Treatment

Topical corticosteroids

Oral corticosteroids

Indicated for vision threatening inflammation

Low to moderate doses for 2 to 3 weeks

Not given alone because of risk of worsened infection

without antibiotic coverage

Periocular steroids felt to be contraindicated

because of reports of uncontrolled infection after injection

Generally not used in immunocompromised patients




INTERMEDIATE UVEITIS (PARS

PLANITIS)

? It denotes inflammation of pars plana part of

ciliary body and most peripheral part of the

retina.

? Etiology. It is an idiopathic disease usually

affecting both eyes of young adults.

? Symptoms. Most of the patients present with

history of floaters. Some patients may come

with defective vision due to associated cystoid

macular oedema.

Signs

? Fundus examination with indirect

ophthalmoscope reveals the whitish exudates

present near the ora serrata in the inferior

quadrant. These typical exudates are referred

as snow ball opacities. These may coalesce to

form a grey white plaque called snow banking.


Complications

? Cystoid macular oedema,

? Complicated cataract and

? Tractional retinal detachment

? Treatment

1. Corticosteroids ( Topical or systemic)

2. Immunosuppressive drugs may be helpful in

steroid resistant cases.

3. Peripheral cryotherapy is also reported to be

effective.

MCQ

1. A 60 yr old female having h/o cataract surgery 1 yr

back. She had complain of sudden onset painful

diminution of vision and was diagnosed as a case of

late onset endophthalmitis. Organism most

commonly implicated is?

? A. Pseudomonas aeruginosa

? B. Staphylococcus epidermidis

? C. Candida albicans

? D. Propionibacterium acnes




MCQ

2. Al of the following are involved in

endophthalmitis except?

? A. Retina

? B. Vitreous

? C. Sclera

? D. Uvea

MCQ

? 3. A 30 yr old female had complains of floaters

with blurring of vision. On indirect ophthalmoscopy

pt had clear central fundus but there was

inflammation of the pheripheral part. What is your

diagnosis?

? A. Panuveitis

? B. Posterior uveitis

? C. Endophthalmitis

? D. Pars planitis


MCQ

? 4. A 50 yr old female having h/o cataract surgery 1

week back. She had complains of sudden onset

painful diminution of vision, redness & watering. On

clinical examination she had hypopyon, AC cells

and flare with vitreous exudates on USG. What is

your diagnosis?

? A. Panuveitis

? B. Posterior uveitis

? C. Endophthalmitis

? D. Panophthalmitis

?

MCQ

? 5. A 30 yrs old male had history of trauma

followed by loss of vision, severe pain, redness

and watering. On clinical examination he had

inflammation of all ocular structures including

tenon's capsule. What is your diagnosis?

? A. Panuveitis

? B. Posterior uveitis

? C. Endophthalmitis

? D. Panophthalmitis


MCQ

? 6. A 50 yr old female having h/o cataract surgery 1

week back. She had complains of sudden onset

painful diminution of vision, redness & watering.

On clinical examination she had hypopyon, AC

cells and flare with vitreous exudates on USG.

Which is the most common organism responsible

for the condition?

? A. Pseudomonas aeruginosa

? B. Staphylococcus epidermidis

? C. Candida albicans

? D. Propionibacterium acnes



MCQ

? 7. A 15 yrs old male had history of penetrating

trauma to right eye followed by loss of vision,

severe pain, redness and watering in the left eye 3

months after trauma . On clinical examination he

retrolental flare with signs of panuveitis. What is

your diagnosis?

? A. Sympathetic ophthalmitis

? B. Posterior uveitis

? C. Endophthalmitis

? D. Panophthalmitis


MCQ

? 8. What is the most common cause of loss of

vision in pars planitis?

? A. Panuveitis

? B. Posterior uveitis

? C. Cystoid macular edema

? D.Floaters

MCQ

9. Snow banking is seen in:

A. Panuveitis

B. Posterior uveitis

C. Endophthalmitis

D. Pars planitis


MCQ

? 10. Dalen-Fuchs' nodules are seen in:

? A. Sympathetic ophthalmitis

? B. Posterior uveitis

? C. Endophthalmitis

? D. Panophthalmitis

THANK YOU

This post was last modified on 07 April 2022