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chemicals
? Regulation of water and electrolyte balances
? Regulation of body fluid osmolality and
electrolyte concentrations
? Regulation of arterial pressure
? Regulation of acid-base balance
? Secretion, metabolism and excretion of
? Gluconeogenesis
? Stellate cells located between endothelium
and basal lamina
? Common in between capillaries
? They are contractile
? Secrete extracellular matrix, take up
diseases
? They regulate GFR
Renal blood flow
? Sympathetic nervous system activation
decreases GFR
? Norepinephrine, Epinephrine and
and decrease GFR
? NO, Prostaglandins and Bradykinin
? Total blood flow through both kidneys is
1100 ml/min or 22% of cardiac output
? Kidneys consume twice the rate of the
brain but receives 7 times the blood flow
Tubulo-glomerular feedback mechanism
chemicals
? Regulation of water and electrolyte balances
? Regulation of body fluid osmolality and
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electrolyte concentrations
? Regulation of arterial pressure
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Functions of Kidneys? Regulation of acid-base balance
? Secretion, metabolism and excretion of
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hormones? Gluconeogenesis
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Mesangial Cells? Stellate cells located between endothelium
and basal lamina
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? Common in between capillaries
? They are contractile
? Secrete extracellular matrix, take up
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immune complexes and involved indiseases
? They regulate GFR
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Physiologic control of GFR andRenal blood flow
? Sympathetic nervous system activation
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decreases GFR
? Norepinephrine, Epinephrine and
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Endothelin constricts renal blood vesselsand decrease GFR
? NO, Prostaglandins and Bradykinin
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increase GFR? Total blood flow through both kidneys is
1100 ml/min or 22% of cardiac output
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? Kidneys consume twice the rate of the
brain but receives 7 times the blood flow
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as brainTubulo-glomerular feedback mechanism
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