At the end of this lecture student should be able to describe
Types of plasma proteins
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Characteristics of plasma proteins
Functions of plasma proteins
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Functions of plasma proteins
1. Col oid osmotic pressure in blood
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2. Viscosity of blood3. Buffer action
4. Clotting and fibrinolysis
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5. Defense function body
6. Transport function
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7. Plasma proteolytic enzyme system8. Plasma protease inhibitor system
9. Reserve Source
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Viscosity of blood
Blood is a viscous fluid and its viscosity is 4-5 times to water or 3.2
centipoise (cP).
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Viscosity of blood is contributed equally by blood cells & plasma proteins.
Viscosity of blood
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Among protein classes, the fibrous proteins fibrinogen - major
contributors of the viscosity.
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Blood viscosity is important to maintain diastolic blood pressure as itcontributes to resistance to blood flow.
Acid Base Buffer
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NH +
COO
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3
-
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PPs provide 15 %buffering capacity of blood. It is possible becauseof their amphoteric nature.
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Coagulation and Fibrinolysis
Process of Coagulation
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Process of AnticlottingBody Defense function
Immunoglobulins ? IMMUNITY
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Five distinct classes of immunoglobulins
Carrier or Transport Function
The bound portion may act as a reservoir or depot from which the drug is
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slowly released as the unbound form.
Unbound form is filtered, excreted and metabolized much faster.
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Examples-Plasma proteolytic enzyme system
There are three important proteolytic enzyme system-
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1. Complement system
2. Fibrinolytic system
3. Kinin system
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Plasma protease inhibitor system
There is a family of proteins which inactivate/ Inhibit the various
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activated enzymatic proteins to regulate many processes:1. Alpha1-protease inhibitor
2. Alpha 2-macroglobulins
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3. Anti thrombin III
4. Alpha 2 antiplasmin
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Reserve Source of Proteins - Act as a source of Aminoacids for body tissues at the time of need.
Plasma protein serves
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`Reserve Proteins'
Factors affecting synthesis of plasma proteins-
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Plasmapheresis (Whipple's Experiment)
Plasmapheresis: a method of removing
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blood plasma from the body bywithdrawing blood, separating it into
plasma and cells, and transfusing the
cells back into the bloodstream.
(Clinical use-It is performed especially to
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remove antibodies in treatingautoimmune conditions).
Self Assessment
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The person whose hematocrit is equal to 60 %with reference to normal has
...................... viscosity of blood.
Normal total plasma protein ranges from ........................
Which component of protein contribute to maximum percentage to total plasma
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protein......................Normal serum albumin level is ............................
Normal A/G ratio in blood is ...........................
Viscosity of blood increased with rise in...........................and..................................
Plasma proteins act as buffers because of ...............................................................
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Buffering capacity of plasma proteins is .......................................of total bufferingcapacity .
Thank you
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