Download MBBS Physiology Presentations 41 Hematology Functions of Plasma Proteins Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) 1st Year, 2nd Year, 3rd Year and Final year Physiology 41 Hematology Functions of Plasma Proteins PPT-Powerpoint Presentations and lecture notes

Cont... Functions of plasma proteins

Learning Objectives:

At the end of this lecture student should be able to describe

Types of plasma proteins

Characteristics of plasma proteins

Functions of plasma proteins


Functions of plasma proteins

1. Col oid osmotic pressure in blood

2. Viscosity of blood

3. Buffer action

4. Clotting and fibrinolysis

5. Defense function body

6. Transport function

7. Plasma proteolytic enzyme system

8. Plasma protease inhibitor system

9. Reserve Source

Viscosity of blood

Blood is a viscous fluid and its viscosity is 4-5 times to water or 3.2
centipoise (cP).

Viscosity of blood is contributed equally by blood cells & plasma proteins.


Viscosity of blood

Among protein classes, the fibrous proteins fibrinogen - major

contributors of the viscosity.

Blood viscosity is important to maintain diastolic blood pressure as it
contributes to resistance to blood flow.

Acid Base Buffer



NH +

COO

3

-

PPs provide 15 %buffering capacity of blood. It is possible because
of their amphoteric nature.




Coagulation and Fibrinolysis

Process of Coagulation

Process of Anticlotting

Body Defense function

Immunoglobulins ? IMMUNITY

Five distinct classes of immunoglobulins
Carrier or Transport Function

The bound portion may act as a reservoir or depot from which the drug is

slowly released as the unbound form.

Unbound form is filtered, excreted and metabolized much faster.

Examples-

Plasma proteolytic enzyme system

There are three important proteolytic enzyme system-

1. Complement system
2. Fibrinolytic system
3. Kinin system


Plasma protease inhibitor system

There is a family of proteins which inactivate/ Inhibit the various

activated enzymatic proteins to regulate many processes:

1. Alpha1-protease inhibitor

2. Alpha 2-macroglobulins

3. Anti thrombin III

4. Alpha 2 antiplasmin

Reserve Source of Proteins - Act as a source of Amino

acids for body tissues at the time of need.

Plasma protein serves

`Reserve Proteins'


Factors affecting synthesis of plasma proteins-

Plasmapheresis (Whipple's Experiment)

Plasmapheresis: a method of removing

blood plasma from the body by
withdrawing blood, separating it into
plasma and cells, and transfusing the
cells back into the bloodstream.
(Clinical use-It is performed especially to
remove antibodies in treating
autoimmune conditions).


Self Assessment

The person whose hematocrit is equal to 60 %with reference to normal has
...................... viscosity of blood.
Normal total plasma protein ranges from ........................
Which component of protein contribute to maximum percentage to total plasma
protein......................
Normal serum albumin level is ............................
Normal A/G ratio in blood is ...........................
Viscosity of blood increased with rise in...........................and..................................
Plasma proteins act as buffers because of ...............................................................
Buffering capacity of plasma proteins is .......................................of total buffering
capacity .


Thank you