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Red Blood Cell Physiology
Learning Objectives
Morphological Features of RBCs
Functions of the RBCs
Hematological Indices
Red Blood Cells
RBC are also known as erythrocytes or red blood corpuscles as it contains
haemoglobin which turns red on binding with oxygen.
It also carries carbon dioxide away from tissues to lungs.
It contains certain antigens on its surface membrane that determine blood
groups and makes basis of whole blood transfusion physiology.
Red Blood Cells
Clinical Application :
Since RBC uses glucose constantly from plasma,
whenever blood glucose level is to be tested, the sample is taken in the
fluoride vial
Red Blood Cells- Morphology-Size
RBCs are anucleated discs
RBC count : 4-6 million/mm3,
Life span - 120 days.
Central pallor is seen due to presence of less haemoglobin
molecule in the centre.
Size ? Diameter: 7-7.8 ?m,
Thickness at the periphery-2.2 ?m and
Centre - 1 ?m
Red Blood Cells- Shape
Shape - Normal biconcave disc
Biconcave shape has many advantages :
1 .Flexibility RBCs
2 .Greater surface area/volume ratio
Red Blood Cells- Normal values
RBCs Count-4-6 million/mm 3
Hb content-14-16 gm/dl
O2 carrying Capacity of blood-1 gm Hb binds
to 1.34 ml of O2
PCV=45?2 ml/100 ml of blood
Hematological Indices
Red blood cell indices are blood tests that provide
information about the average volume or size (MCV) and
hemoglobin content (MCH, MCHC) of red blood cell.
Mean Corpuscular Volume (MCV)
Mean corpuscular volume (MCV) is the
average volume of a single rbc.
We need values of:
RBC count PCV
= PCV X 10 ??
RBCs
= 80-100 ??
Mean Corpuscular Hemoglobin (MCH)
Mean corpuscular hemoglobin (MCH) is the average amount of
hemoglobin of a single rbc.
We need values of:
RBC count Hb
= Hb X 10 pg
RBCs
= 27-32 pg
Mean Corpuscular Hemoglobin Conc. (MCHC)
Mean corpuscular hemoglobin Concentration (MCHC) is the average
concentration of hemoglobin per unit volume of red blood cells.
We need values of:
PCV Hb
= Hb X 100 g
PCV
32-36 %
Self Asessment
What is normal RBC Count-
a. 4000-6000/mm3
b. 4lac-6 lac/mm3
c. 4 million to 6 million/mm3
d. 4 billion to 6 billion/mm3
What is the life span of RBCs-
a. 1 month
b. 2 months
c. 3 months
d. 4 months
What is the term used to describe a cell of normal color?
?A.-Normochromic
?B. Hypochromic
?C. Polychromic
?D Euchromic
Self Asessment
What are the formula and normal value of MCV-------------------------------
What are the formula and normal value of MCH-------------------------------
What are the formula and normal value of MCHC-----------------------------
What are the causes of Normocytic normochromic anemia-----------------
What are the causes of Microcytic hypochromic anemia---------------------
What are the causes of Macrocytic anemia----------------------------------
Thank you
This post was last modified on 08 April 2022