Functions of the RBCs
Hematological Indices
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Red Blood CellsRBC are also known as erythrocytes or red blood corpuscles as it contains
haemoglobin which turns red on binding with oxygen.
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It also carries carbon dioxide away from tissues to lungs.It contains certain antigens on its surface membrane that determine blood
groups and makes basis of whole blood transfusion physiology.
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Red Blood Cells
Clinical Application :
Since RBC uses glucose constantly from plasma,
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whenever blood glucose level is to be tested, the sample is taken in thefluoride vial
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Red Blood Cells- Morphology-Size
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RBCs are anucleated discsRBC count : 4-6 million/mm3,
Life span - 120 days.
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Central pallor is seen due to presence of less haemoglobin
molecule in the centre.
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Size ? Diameter: 7-7.8 ?m,Thickness at the periphery-2.2 ?m and
Centre - 1 ?m
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Red Blood Cells- Shape
Shape - Normal biconcave disc
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Biconcave shape has many advantages :1 .Flexibility RBCs
2 .Greater surface area/volume ratio
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Red Blood Cells- Normal valuesRBCs Count-4-6 million/mm 3
Hb content-14-16 gm/dl
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O2 carrying Capacity of blood-1 gm Hb binds
to 1.34 ml of O2
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PCV=45?2 ml/100 ml of bloodHematological Indices
Red blood cell indices are blood tests that provide
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information about the average volume or size (MCV) and
hemoglobin content (MCH, MCHC) of red blood cell.
Mean Corpuscular Volume (MCV)
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Mean corpuscular volume (MCV) is the
average volume of a single rbc.
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We need values of:RBC count PCV
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= PCV X 10 ?RBCs
= 80-100 ?
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Mean Corpuscular Hemoglobin (MCH)
Mean corpuscular hemoglobin (MCH) is the average amount of
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hemoglobin of a single rbc.We need values of:
RBC count Hb
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= Hb X 10 pg
RBCs
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= 27-32 pgMean Corpuscular Hemoglobin Conc. (MCHC)
Mean corpuscular hemoglobin Concentration (MCHC) is the average
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concentration of hemoglobin per unit volume of red blood cells.We need values of:
PCV Hb
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= Hb X 100 g
PCV
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32-36 %
Self Asessment
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What is normal RBC Count-a. 4000-6000/mm3
b. 4lac-6 lac/mm3
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c. 4 million to 6 million/mm3
d. 4 billion to 6 billion/mm3
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What is the life span of RBCs-a. 1 month
b. 2 months
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c. 3 months
d. 4 months
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What is the term used to describe a cell of normal color??A.-Normochromic
?B. Hypochromic
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?C. Polychromic
?D Euchromic
Self Asessment
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What are the formula and normal value of MCV-------------------------------
What are the formula and normal value of MCH-------------------------------
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What are the formula and normal value of MCHC-----------------------------What are the causes of Normocytic normochromic anemia-----------------
What are the causes of Microcytic hypochromic anemia---------------------
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What are the causes of Macrocytic anemia----------------------------------
Thank you
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