Download MBBS Physiology Presentations 57 Hematology Rbcs Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) 1st Year, 2nd Year, 3rd Year and Final year Physiology 57 Hematology Rbcs PPT-Powerpoint Presentations and lecture notes


Red Blood Cell Physiology

Learning Objectives

Morphological Features of RBCs

Functions of the RBCs

Hematological Indices
Red Blood Cells

RBC are also known as erythrocytes or red blood corpuscles as it contains
haemoglobin which turns red on binding with oxygen.

It also carries carbon dioxide away from tissues to lungs.

It contains certain antigens on its surface membrane that determine blood

groups and makes basis of whole blood transfusion physiology.

Red Blood Cells

Clinical Application :
Since RBC uses glucose constantly from plasma,
whenever blood glucose level is to be tested, the sample is taken in the
fluoride vial






Red Blood Cells- Morphology-Size

RBCs are anucleated discs

RBC count : 4-6 million/mm3,

Life span - 120 days.

Central pallor is seen due to presence of less haemoglobin

molecule in the centre.

Size ? Diameter: 7-7.8 ?m,

Thickness at the periphery-2.2 ?m and

Centre - 1 ?m

Red Blood Cells- Shape

Shape - Normal biconcave disc

Biconcave shape has many advantages :

1 .Flexibility RBCs

2 .Greater surface area/volume ratio
Red Blood Cells- Normal values

RBCs Count-4-6 million/mm 3

Hb content-14-16 gm/dl

O2 carrying Capacity of blood-1 gm Hb binds

to 1.34 ml of O2

PCV=45?2 ml/100 ml of blood

Hematological Indices

Red blood cell indices are blood tests that provide

information about the average volume or size (MCV) and

hemoglobin content (MCH, MCHC) of red blood cell.
Mean Corpuscular Volume (MCV)

Mean corpuscular volume (MCV) is the

average volume of a single rbc.

We need values of:

RBC count PCV


= PCV X 10 ??

RBCs

= 80-100 ??

Mean Corpuscular Hemoglobin (MCH)

Mean corpuscular hemoglobin (MCH) is the average amount of

hemoglobin of a single rbc.

We need values of:

RBC count Hb

= Hb X 10 pg

RBCs

= 27-32 pg
Mean Corpuscular Hemoglobin Conc. (MCHC)

Mean corpuscular hemoglobin Concentration (MCHC) is the average

concentration of hemoglobin per unit volume of red blood cells.

We need values of:

PCV Hb


= Hb X 100 g

PCV

32-36 %

Self Asessment

What is normal RBC Count-

a. 4000-6000/mm3

b. 4lac-6 lac/mm3

c. 4 million to 6 million/mm3

d. 4 billion to 6 billion/mm3

What is the life span of RBCs-

a. 1 month

b. 2 months

c. 3 months

d. 4 months

What is the term used to describe a cell of normal color?

?A.-Normochromic

?B. Hypochromic

?C. Polychromic

?D Euchromic
Self Asessment

What are the formula and normal value of MCV-------------------------------

What are the formula and normal value of MCH-------------------------------

What are the formula and normal value of MCHC-----------------------------

What are the causes of Normocytic normochromic anemia-----------------

What are the causes of Microcytic hypochromic anemia---------------------

What are the causes of Macrocytic anemia----------------------------------

Thank you

This post was last modified on 08 April 2022