Download MBBS Physiology Presentations 58 Hematology Erythropoiesis Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) 1st Year, 2nd Year, 3rd Year and Final year Physiology 58 Hematology Erythropoiesis PPT-Powerpoint Presentations and lecture notes

Erythropoiesis

Learning Objectives

Stem cells

Process of erythropoiesis - site, stages

Factors affecting erythropoiesis




Hematopoiesis

The process of formation of new blood cells

Lineage Cells of Hematopoiesis- HSCs

Blood (Hemopoietic) Stem Cells

Hemopoi

etic Stem

are divided into:

Cells

1. Myeloid stem cells or

2. Lymphoid stem cells

In bone marrow

4


Stem Cells

Stem cells : Cells that are able to

1) Self-renew to form `parent pool' (can create

more stem cells indefinitely)

2) Differentiate into (become) specialized,

mature cell types.

Site of Hematopoiesis

During fetal life

After birth

1) Yolk sac:

Active (red) BM:

2) Liver & Spleen:
3) Bone marrow (BM):

In infancy & childhood

In adult


Characteristics of Bone Marrow

One of the largest organs in body.

1011-1012 Cells are daily formed to be taken to the periphery through blood vessels

Steps of Erythropoiesis

Lymphoid Stem Cel s

COMMITTED STEM CELLS or

Progenitor cel s

HSC

Colony Forming Unit-Blast (CFU-B) Colony Forming Unit-Erythroblast

(CFU-E)

Myeloid Stem Cel s

Colony Forming Unit ? Spleen (CFU-S) CFU GM

CFU M

MSC CFU-B CFU-E
? Pronormoblast

? Basophilic normoblast
? Polychromatophilic Normoblast
? Orthrochromatophilic Normoblast
? Reticulocyte
? Mature Red Blood Cell




Stages of Erythropoiesis

Pronormoblast (Proerythroblast)

Stages of Erythropoiesis

Early Normoblast (basophilic normoblast)




Stages of Erythropoiesis

Intermediate normoblast

(polychromatic normoblast)

Stages of Erythropoiesis

Late Normoblast (Orthochromatic Normoblast)




Stages of Erythropoiesis

Reticulocyte

Mature RBC

Factors regulating Erythropoiesis

Growth or Developmental Factors

Nutritional Factors

Hormonal Factors

Healthy Liver and Bone marrow
Self Assessment

1) After birth all blood cells except ............................ are formed in bone marrow.
2) In adults hemopoietic bone marrow is confined to axial skeleton and ......................of humerus & femur.


3) Interleukins .........................................to convert PHSC to Committed Progenitor cells.
4) .................................can be stimulated to form any cell in the body.


5) Hemoglobin first appears in .....................................stage of Erythropoiesis.
6) In early normoblast stage of Erythropoiesis, cell cytoplasm is stained by ..................... dye.
7) Erythropoietin is secreted from ............................of kidney.
8) ...............................are important in the maturation of the RBCs.
9) RBCs do not contain a nucleus, endoplasmic reticulum and .........................
10) 1 gm of hemoglobin contains...............................iron.

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