Process of erythropoiesis - site, stages
Factors affecting erythropoiesis
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Hematopoiesis
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The process of formation of new blood cells
Lineage Cells of Hematopoiesis- HSCs
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Blood (Hemopoietic) Stem CellsHemopoi
etic Stem
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are divided into:
Cells
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1. Myeloid stem cells or2. Lymphoid stem cells
In bone marrow
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4
Stem Cells
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Stem cells : Cells that are able to
1) Self-renew to form `parent pool' (can create
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more stem cells indefinitely)2) Differentiate into (become) specialized,
mature cell types.
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Site of Hematopoiesis
During fetal life
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After birth1) Yolk sac:
Active (red) BM:
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2) Liver & Spleen:
3) Bone marrow (BM):
In infancy & childhood
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In adult
Characteristics of Bone Marrow
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One of the largest organs in body.
1011-1012 Cells are daily formed to be taken to the periphery through blood vessels
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Steps of ErythropoiesisLymphoid Stem Cel s
COMMITTED STEM CELLS or
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Progenitor cel s
HSC
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Colony Forming Unit-Blast (CFU-B) Colony Forming Unit-Erythroblast(CFU-E)
Myeloid Stem Cel s
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Colony Forming Unit ? Spleen (CFU-S) CFU GM
CFU M
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MSC CFU-B CFU-E? Pronormoblast
? Basophilic normoblast
? Polychromatophilic Normoblast
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? Orthrochromatophilic Normoblast? Reticulocyte
? Mature Red Blood Cell
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Stages of Erythropoiesis
Pronormoblast (Proerythroblast)
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Stages of Erythropoiesis
Early Normoblast (basophilic normoblast)
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Stages of Erythropoiesis
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Intermediate normoblast(polychromatic normoblast)
Stages of Erythropoiesis
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Late Normoblast (Orthochromatic Normoblast)
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Stages of Erythropoiesis
Reticulocyte
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Mature RBCFactors regulating Erythropoiesis
Growth or Developmental Factors
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Nutritional Factors
Hormonal Factors
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Healthy Liver and Bone marrowSelf Assessment
1) After birth all blood cells except ............................ are formed in bone marrow.
2) In adults hemopoietic bone marrow is confined to axial skeleton and ......................of humerus & femur.
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3) Interleukins .........................................to convert PHSC to Committed Progenitor cells.
4) .................................can be stimulated to form any cell in the body.
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5) Hemoglobin first appears in .....................................stage of Erythropoiesis.
6) In early normoblast stage of Erythropoiesis, cell cytoplasm is stained by ..................... dye.
7) Erythropoietin is secreted from ............................of kidney.
8) ...............................are important in the maturation of the RBCs.
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9) RBCs do not contain a nucleus, endoplasmic reticulum and .........................10) 1 gm of hemoglobin contains...............................iron.
Thank you
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