Hemoglobin catabolism (Fate of old RBCs)
Prehepatic Jaundice
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Iron (Fe+2) MetabolismIron is essential for
formation of Heme part of Hemoglobin
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and other heme containing substances
Iron (Fe+2) Metabolism
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Normal serum iron level (50-170 g/dL)Total Iron Binding Capacity of blood (TIBC) ? Nr : 240 ? 450 g/dL
Serum ferritin=Normal value ? 25 -75 ng/mL
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Iron (Fe+2) Metabolism Distribution
The total body iron content is = 4 ? 5 gm
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Distribution in body-
Iron Regulation in body ?happens at the level of absorption-HOW
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HEPCIDIN is the key regulator of iron in our body by regulating itsabsorption and release
Hypoxia
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Hemoglobin Catabolism (destruction of old RBCs)
? Red cell destruction usual y occurs
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after an average life span of 120 days? The cells are removed extravascularly
by macrophages special y in the spleen
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but also in bone marrow and liver.Hemoglobin Catabolism (destruction of old RBCs)
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Hemoglobin Catabolism (destruction of old RBCs)Hemoglobin Catabolism (destruction of old RBCs)
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Hemoglobin Catabolism - JaundiceJaundice is also called icterus. It is yellow discoloration of the skin, subcutaneous tissue
and bulbar sclera, due to an increase of bile pigments in the blood
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Normal levels vary slightly from lab to lab; they range from about 0.2 ? 1.2 mg/dL.
According to causes of Jaundice-
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Pre-hepatic JaundiceHepatic Jaundice
Obstructive Jaundice
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Hemoglobin Catabolism - Jaundice
Self Assesment
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1. Normal serum iron level is--------------------------------------------------------
2. Total Iron Binding Capacity of blood (TIBC) ? Nr value--------------------
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3. Serum ferritin=Normal value ------------------------------------------------4. Low levels of ferritin are indicative of ----------------------------------------------------
5. Normal Iron distribution to Hb is ------------(g), to Myoglobin -----------(g)and to Ferritin---------(g)
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6. Avg daily intake - about ----------------- mg and the amount of iron absorbed is normally about
--------------% or --------------------- mg.
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7. Avg daily loss is about ---------------------------mg through ----------------------------------------
8. Excess iron combines with--------------------------forming tissue ferritin in macrophages in
-----------------------mainly and ----------------------.
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