Download MBBS Physiology Presentations 60 Hematology Iron Metabolism Lecture Notes

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) 1st Year, 2nd Year, 3rd Year and Final year Physiology 60 Hematology Iron Metabolism PPT-Powerpoint Presentations and lecture notes

Iron metabolism & Hemoglobin catabolism

Learning Objectives

Iron metabolism

Hemoglobin catabolism (Fate of old RBCs)

Prehepatic Jaundice
Iron (Fe+2) Metabolism

Iron is essential for

formation of Heme part of Hemoglobin

and other heme containing substances

Iron (Fe+2) Metabolism

Normal serum iron level (50-170 g/dL)
Total Iron Binding Capacity of blood (TIBC) ? Nr : 240 ? 450 g/dL
Serum ferritin=Normal value ? 25 -75 ng/mL




Iron (Fe+2) Metabolism Distribution

The total body iron content is = 4 ? 5 gm

Distribution in body-

Iron Regulation in body ?happens at the level of absorption-HOW






HEPCIDIN is the key regulator of iron in our body by regulating its

absorption and release

Hypoxia

Hemoglobin Catabolism (destruction of old RBCs)

? Red cell destruction usual y occurs

after an average life span of 120 days

? The cells are removed extravascularly

by macrophages special y in the spleen
but also in bone marrow and liver.


Hemoglobin Catabolism (destruction of old RBCs)

Hemoglobin Catabolism (destruction of old RBCs)


Hemoglobin Catabolism (destruction of old RBCs)

Hemoglobin Catabolism - Jaundice

Jaundice is also called icterus. It is yellow discoloration of the skin, subcutaneous tissue

and bulbar sclera, due to an increase of bile pigments in the blood

Normal levels vary slightly from lab to lab; they range from about 0.2 ? 1.2 mg/dL.

According to causes of Jaundice-

Pre-hepatic Jaundice

Hepatic Jaundice

Obstructive Jaundice


Hemoglobin Catabolism - Jaundice

Self Assesment

1. Normal serum iron level is--------------------------------------------------------

2. Total Iron Binding Capacity of blood (TIBC) ? Nr value--------------------

3. Serum ferritin=Normal value ------------------------------------------------

4. Low levels of ferritin are indicative of ----------------------------------------------------

5. Normal Iron distribution to Hb is ------------(g), to Myoglobin -----------(g)and to Ferritin---------(g)

6. Avg daily intake - about ----------------- mg and the amount of iron absorbed is normally about


--------------% or --------------------- mg.

7. Avg daily loss is about ---------------------------mg through ----------------------------------------

8. Excess iron combines with--------------------------forming tissue ferritin in macrophages in
-----------------------mainly and ----------------------.
Thank you