HEALTH SCIENCES
WARANGAL, TELANGANA STATE-506 002
MBBS FIRST YEAR EXAMINATIONS:
SEPTEMBER, 2025
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PHYSIOLOGYPAPER-I
Time: 3 Hours
Max Marks: 100
Note: Answer all questions
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Give Diagrammatic representation wherever necessaryMultiple Choice Questions:
1. Hering Breuer Reflex protects lung from
a) Circulating Toxins
c) Overinflation
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b) Circulating Phagocytesd) Under Ventilation
2. Which of the following organs has the greatest blood
flow per 100g of tissue?
a) Brain
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c) Kidneyb) Skin
d) Liver
3. The most appropriate index of left ventricular afterload
is
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a) Systolic arterial pressure
c) Systermic vascular resistance
b) Mean arterial pressure
d) Left ventricular systolic pressure
4. Major source of ammonia production in renal tubular
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cell is bya) Deamination of glutamine
b) Deamination of glutamic acid
c) Deamination of other amino acids, glycine,
asparagine, alanine
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d) Comes directly from arterial blood5. Cholerectics are the substances which causes
a) Contraction of gall bladder
c) Neutralization of acid from stomach
b) Increase biliary secretion from liver
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d) Solubility of fats in micelles6. First heart sound (HS1):
a) Marks the onset of ventricular systole
b) Caused by the closure of semilunar valves
c) Best heard over aortic and pulmonary areas
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d) Characterized by high pitch and sharp sound7. The renal "countercurrent" mechanism is dependent
upon the anatomic relationship between:
a) The distal tubule and the macula densa
c) The loop of Henle and the vasa recta
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b) The loop of Henle and the macula densad) The glomerulus and the afferent and efferent
arterioles
8. The adhesion of platelets to subendothelial collagen is
impaired in the absence of
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a) Von Willebrand factorc) Heparin
b) Plasmin
d) Antithrombin III
9. The function of axonemal dynein is?
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a) Moves particles to the 'mimas' end of microtubule.c) Responsible for the beating of flagella and cilia
b) Moves particles towards 'plus' end of microtubule
d) Binds to actin and produce motion by bending their
neck region.
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10. Cholesterol content of a cell membrane influenceswhich of the following characteristics of biological
membrane
a) Ion permeability
c) Glycosylation
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b) Fluidityd) Hydrophobicity
Essay/ Long Answer Questions:
11. An elderly male came to hospital with history of chest
pain and breathing difficulty on and off for 2 days. His
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ECG showed ST segment depression andechocardiography showed that his stroke volume in <50%.
a) Identify the condition.
b) Define stroke volume, cardiac output and cardiac
index with their normal value.
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c) Describe the factors regulating cardiac output.d) Define Fick's principle. Mention the methods to
measure cardiac output.
12. A young male went for trekking 2500m above sea
level. On arrival to his stay, he complained of
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breathlessness. His Spo, was 70% in room air.a) Identify the condition
b) Describe the classification and pathophysiology of
Hypoxia
c) Enumerate the treatment for the types of Hypoxia
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d) Discuss on Hyperbaric O, therapyShort Answer Questions:
13. Describe the mechanism of HCl secretion in stomach.
14. Name the different body fluid compartments. Give the
composition of extracellular and intracellular fluids.
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Mention the methods to measure ECF.15. Describe Defecation reflex.
16. Classify leukocytes. Describe the stages of
leucopoiesis.
17. Define haemostasis. Describe the extrinsic
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mechanism of coagulation.18. Enumerate the measures that strengthen the doctor
patient relationship.
19. Briefly explain water reabsorption by Kidney.
Very Short Answer Questions:
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20. Draw a neat labelled diagram of nerve actionpotential mentioning reasons for each phase.
21. List functions of plasma proteins.
22. Draw a neat labelled diagram of Juxtaglomerular
apparatus.
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23. Define uniport, symport and antiport with examples.24. Define urea clearance. How is it calculated. Name
any other 2 substances used to measure renal clearance.
25. Write the significance of Dietary fibers.
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