KALOJI NARAYANA RAO UNIVERSITY OF
HEALTH SCIENCES
WARANGAL, TELANGANA STATE - 506 002
MBBS FIRST YEAR EXAMINATIONS:
SEPTEMBER, 2025

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PHYSIOLOGY
PAPER - I
(NEW SCHEME)
Time: 3 Hours
Max Marks: 100

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Note: Answer all questions
Give Diagrammatic representation wherever necessary
Multiple Choice Questions: 10 x 1 = 10
1. Hering Breuer Reflex protects lung from
a) Circulating Toxins

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c) Overinflation
b) Circulating Phagocytes
d) Under Ventilation
2. Which of the following organs has the greatest blood
flow per 100g of tissue?

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a) Brain
c) Kidney
b) Skin
d) Liver
3. The most appropriate index of left ventricular afterload

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is
a) Systolic arterial pressure
c) Systemic vascular resistance
b) Mean arterial pressure
d) Left ventricular systolic pressure

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4. Major source of ammonia production in renal tubular
cell is by
a) Deamination of glutamine
c) Deamination of other amino acids, glycine,
asparagine, alanine

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b) Deamination of glutamic acid
d) Comes directly from arterial blood
5. Cholerectics are the substances which causes
a) Contraction of gall bladder
c) Neutralization of acid from stomach

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b) Increase biliary secretion from liver
d) Solubility of fats in micelles
6. First heart sound (HS1):
a) Marks the onset of ventricular systole
c) Best heard over aortic and pulmonary areas

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b) Caused by the closure of semilunar valves
d) Characterized by high pitch and sharp sound
7. The renal "countercurrent" mechanism is dependent
upon the anatomic relationship between:
a) The distal tubule and the macula densa

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c) The loop of Henle and the vasa recta
b) The loop of Henle and the macula densa

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d) The glomerulus and the afferent and efferent
arterioles
8. The adhesion of platelets to subendothelial collagen is

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impaired in the absence of:
a) Von Willebrand factor
c) Heparin
b) Plasmin
d) Antithrombin III

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9. The function of axonemal dynein is?
a) Moves particles to the 'minus' end of microtubule.
c) Responsible for the beating of flagella and cilia.
b) Binds to actin and produce motion by bending their
neck region.

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d) Moves particles towards 'plus' end of microtubule.
10. Cholesterol content of a cell membrane influences
which of the following characteristics of biological
membrane
a) Ion permeability

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c) Glycosylation
b) Fluidity
d) Hydrophobicity
Essay/ Long Answer Questions: 2 x 15 = 30
11. An elderly male came to hospital with history of chest

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pain and breathing difficulty on and off for 2 days. His
ECG showed ST segment depression and
echocardiography showed that his stroke volume in <50%.
a) Identify the condition.

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b) Define stroke volume, cardiac output and cardiac

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index with their normal value.
c) Describe the factors regulating cardiac output.
d) Define Fick's principle. Mention the methods to
measure cardiac output.
(1+3+6+5)

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12. A young male went for trekking 2500m above sea
level. On arrival to his stay, he complained of
breathlessness. His Spo was 70% in room air.
a) Identify the condition.
b) Describe the classification and pathophysiology of

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Hypoxia
c) Enumerate the treatment for the types of Hypoxia
d) Discuss on Hyperbaric O therapy.
(1+6+6+2)
Short Answer Questions: 7 x 6 = 42

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13. Describe the mechanism of HCL secretion in stomach
[6]
14. Name the different body fluid compartments. Give the
composition of extracellular and intracellular fluids.
Mention the methods to measure ECF. [6]

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15. Describe Defecation reflex. [6]
16. Classify leukocytes. Describe the stages of
leucopoiesis. [6]
17. Define haemostasis. Describe the extrinsic
mechanism of coagulation. [6]

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18. Enumerate the measures that strengthen the doctor
patient relations. [6]
19. Briefly explain water reabsorption by Kidney. [6]
Very Short Answer Questions: 6 x 3 = 18
20. Draw a neat labelled diagram of nerve action

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potential mentioning reasons for each phase. [3]
21. List functions of plasma proteins [3]
22. Draw a neat labelled diagram of Juxtaglomerular
apparatus. [3]
23. Define uniport, symport and antiport with examples.

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[3]
24. Define urea clearance. How is it calculated. Name
any other 2 substances used to measure renal clearance.
[3]
25. Write the significance of Dietary fibres. [3]

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