HEALTH SCIENCES
WARANGAL, TELANGANA STATE-506 002
MBBS FIRST YEAR SUPPLEMENTARY
EXAMINATIONS: FEBRUARY/MARCH, 2024
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BIOCHEMISTRY (New Regulation)PAPER - II
Time: 3 Hours
Max Marks: 100
Note: Answer all questions Draw diagrams whenever
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necessary with Black Ball point pen/HB pencil/any darkColour pencil
Multiple Choice Questions: 10 X 1=10
1) A Zwitter ion is
a) Positive
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c) No net chargeb) Negative
d) None of the above
2) The major donor of carbon atom to the one carbon pool
is
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a) Serinec) Threonine
b) Tyrosine
d) Proline
3) Which enzyme protects DNA from ageing.
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a) DNA polymerase
c) Deoxyribonuclease
b) Topoisomerase
d) Telomerase
4) Which amino acid is required for both purine and
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pyramidine synthesis.a) Glycine
c) Alanine
b) Aspartate
d) Glutamine
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5) Which one of the following is a termination codon inmitochondrial translation
a) UAA
c) UGA
b) UAG
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d) AGA6) Tumour marker for prostate cancer are
a) Alkaline phosphatase
c) Bence-Jones proteins
b) Prostate specific antigen
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d) Calcitonin7) Which of the following diseases are not attributed to
free radical damage.
a) Rheumatoid arthritis
c) Hypothyroidism
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b) Chronic glomerulonephritisd) Cataract
8) The predominant cation in extracellular fluid (ECF) is
a) Na
c) Ca
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b) Kd) Mg
9) At the pH of blood 7.4, the ratio between the carbonic
acid and bicarbonate fractions is
a) 1:10
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c) 1:30b) 1:20
d) 1:40
10) Monoclonal antibodies are useful for
a) Early detection of pregnancy
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c) Treatment of autoimmune diseasesb) Treatment of cancer
d) All the above
Essay/ Long Answer Questions: 2 X 15=30
11) Why is ammonia toxic to the body. Describe the
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metabolic reactions involved in the detoxification ofammonia. Add a note on the defects in the metabolic cycle
associated with detoxification of ammonia. (4+7+4)
12) What is the normal blood pH. Explain the role of
plasma buffers and renal mechanism in the maintenance
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of acid base balance of the body. (1+7+7)Short Answer Questions: 7X6=42
13) Describe the metabolism of polyamines; functions
and clinical importance.
14) Describe on biosynthesis of Haem, add a note on
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regulation of Haem synthesis.15) Describe the purine salvage pathway. Add a note
Lesch Nyhan syndrome.
16) Mention about the principles, basic mechanism and
tools of recombinant DNA technology.
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17) Discuss on the classification of liver function tests indetail. And explain the mechanism of Vanden Berg test
reaction.
18) Discuss how lifelong learning helps the growth of a
physician.
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19) Explain the mechanism of Hormone action.Very Short Answer Questions: 6X3=18
20) What is genetic code? Describe the characteristics of
genetic code.
21) Detoxification by conjugation.
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22) Structure of Immunoglobulin.23) Describe the composition and functions of
extracellular matrix.
24) Mention anticancer drugs used in chemotherapy and
their mode of action.
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25) Orotic Aciduria.***