KALOJI NARAYANA RAO UNIVERSITY OF
HEALTH SCIENCES
WARANGAL, TELANGANA STATE-506 002
MBBS FIRST YEAR EXAMINATIONS:
SEPTEMBER, 2025

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BIOCHEMISTRY
PAPER-I
Time: 3 Hours
Max Marks: 100
Note: Answer all questions

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Give Diagrammatic representation wherever necessary
Multiple Choice Questions:
10 X 1 = 10
1) Which one of the following statement is correct
regarding HDL (High density lipoprotein)

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a) It transport dietary lipids from the intestine to various
tissues
c) It transports cholesterol from the peripheral tissues to
the liver
b) It transports endogenous lipids from the liver to the

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peripheral tissues
d) It transports the fatty acids released by lipolysis
2) During starvation, the brain derives most of its energy
needs by utilizing the following
a) Fatty acids

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c) Amino acids
b) Ketone bodies
d) Glucose
3) Enzymes catalyzing electron transport are present
mainly in the

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a) Ribosomes
b) Endoplasmic reticulum
c) Lysosomes Enolase
d) Inner mitochondrial membrane
4) The carbohydrate of the blood group substances is

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a) Sucrose
b) Fucose
c) Arabinose
d) Maltose
5) Fluoride inhibits __________________ and arrests

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glycolysis.
a) Glyceraldehyde-3-phosphate dehydrogenase
c) Enolase
b) Aconitase
d) Succinate DH

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6) All the following statements about carnitine are true
except
a) It can be synthesized in the human body
c) It is required for transport of short chain fatty acids
into mitochondria

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b) It can be synthesized from methionine and lysine
d) Its deficiency can occur due to haemodialysis

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7) Lieberman-Burchard reaction is performed to detect
a) Cholesterol
b) Glycerol

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c) Fatty acid
d) Vitamin D
8) The active form of vitamin D is
a) 1,25-DHCC
b) 1,24-DHCC

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c) 24,25-DHCC
d) 25-HCC
9) Kwashiorkor occurs when the diet is severely deficient
in
a) Iron

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c) Proteins
b) Calories
d) Essential fatty acids
10) Keshan disease occurs due to the deficiency of
a) Selenium

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c) Cobalt
b) Chromium
d) Manganese
Essay/ Long Answer Questions:
2 X 15 = 30

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11) A 60-year-old male presented with acute chest pain of
? hour duration. His past history reveals as a known
diabetic; known hypertensive, known smoker and known
alcoholic. The biochemical analysis are as follows: Blood

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glucose-380 mg%, Serum cholesterol = 300 mg% AST-60

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U/L, ALT-15 U/L, CPK & LDH were elevated.
a) Give your provisional diagnosis and meaning of it.
b) Explain in detail about cardiac markers with graph
patterns.
c) What are the other markers which can be estimated

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in this case.
d) Write the normal values of all of the above lab tests.
(3+5+3+4)
12) Write in detail on the metabolism of Iron- the
essential trace element in the following headings

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a) What are the other essential trace elements, name
them?
b) Describe the dietary source, daily requirement,
factors affecting 'Fe' absorption, transport, storage,
biochemical functions and deficiency manifestations of

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the mineral.
c) Specially explain the mucosal block theory of Iron
absorption to support the statement Iron is a one-way
element.
(1+10+4)

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Short Answer Questions:
7X6 = 42
13) Write about the structural and functional organization
of electron transport chain. Add a note on inhibitors of it.
14) Write about Ketone body's synthesis and discuss the

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importance.

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15) Describe the role of a physician in health care system
16) Discuss in detail on the regulation of blood glucose
level (Homeostasis of blood glucose level) and define
hypoglycaemia., Write in detail on various causes of

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Hypoglycaemia.
17) Define phospholipids. State their function and
importance
18) Write in detail on the biochemical function, RDA,
and deficiency manifestations of Vitamin A.

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19) Discuss in detail on the transport
mechanisms/process across the cell membranes.
Very Short Answer Questions:
6X3 = 18
20) What is the principle, procedure and clinical

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application of radio immunoassay.
21) Mention biological active form of folic acid. How is it
involved in one carbon metabolism?
22) Polysaccharides.
23) Vitamin K cycle-biochemical function of vitamin K.

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24) Glycogen storage disorders.
25) Biochemical function of selenium.
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