Download SGBAU B-Pharma 2019 Summer 4th Sem Sem IV Medical Chemistry I New Question Paper

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B.Pharm. Fourth Semester (New)

Medical Chemistry - I: BP 402 T

Pages: 3

Time: Three Hours

Notes:

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1. Answer all questions.
2. Illustrate your answer with the help of neat sketches.
3. Discuss the reaction, mechanism wherever necessary.
4. Use of pen Blue/Black ink/refill only for writing the answer book.

1. Multiple choice questions. 20

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1. If more the lipid / water partition coefficient more will be -------- -
   1. Water solubility
   2. Lipophilicity
   3. Hydrophilicity
   4. Both A & B

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2. Conjugation of a drug includes the following except.
   1. Glucuronidation
   2. Sulfate formation
   3. Hydrolysis
   4. Methylation

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3. Which of the following drugs produce positive inotropic & negative chronotropic action.
   1. Dopamine
   2. Epinephrine
   3. Digoxin
   4. Isoprenaline

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4. Which of the following is selective alpha receptor antagonist.
   1. Clonidine
   2. Phentolamine
   3. Prazosin
   4. Yohimbine

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5. One of the following is resistant to both true & Pseudo cholinesterase enzyme:
   1. Carbachol
   2. Acetilcholine
   3. Methacholine
   4. Pilocarpine

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6. An anti-cholinesterase which is used in Alzheimer’s disease is
   1. Arecolin
   2. Donepezil
   3. Isoproternol
   4. Physostigmine

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7. The neurotransmitter released at synaptic nerve vessels fiber is
   1. Epinephrine
   2. Nor-epinephrine
   3. Acetylcholine
   4. Physostigmine

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8. Skeletal muscle relaxation produced by the drug effectively antagonize by neostigmine.
   1. Diazepam
   2. Succinylcholine
   3. Tubocurarine
   4. Aminophylline

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9. Neuromuscular blocking agents a per action are
   1. Non-depolarizing blocking agent
   2. Depolarizing agent
   3. Both
   4. None of these

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10. Substitution of alkyl group on which position make the compound hypnotics.
    1. C6
    2. C4
    3. C2
    4. C6

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11. Hypnotic benzodiazepines increase the period of time spent in the following.
    1. Stage-II
    2. Stage - III
    3. Stage-IV
    4. Stage of REM

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12. Thioridazine have common ---------- as a side effects.
    1. Cardiac arrhythmias
    2. Interference with male sexual function
    3. Both a & b
    4. None of these

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13. Huntington’s disease is mostly treated by -------
    1. Flupenthixol
    2. Clozapine
    3. Trifluperidol
    4. Haloperidol

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14. The COX-2 inhibitor is not given if patient suffering or already taking.
    1. Anti-allergic drug
    2. Anxiolytic drug
    3. Antihypertensive drug
    4. Anti-diabetic drug

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15. Isoenzyme primarily responsible for PGs production by cells involve in inflammation.
    1. COX-I
    2. COX-II
    3. Both a & b
    4. None of these

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16. Following are the action of morphine except.
    1. Respiratory centre depression
    2. Cough centre depression
    3. Biliary colic
    4. Diarrhoea

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17. The nature of morphine molecule is
    1. Acidic
    2. Phenolic
    3. Basic
    4. Neutral

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18. Problem associated with nitrous oxide anaesthesia is
    1. Behavioural problem
    2. Sensitizes the heart to adrenaline
    3. Prolonged difficult induction
    4. Tachycardia or arrhythmia occurs

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19. Ketamine is a
    1. Short acting general anesthetic agents
    2. Local Anesthetic agents
    3. Antidepressive agent
    4. Hypnotic agent

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20. Which of the following NSAID’s is a selective COX — II inhibitor.
    1. Piroxicam
    2. Indometacin
    3. Celecoxib
    4. Diclofenac

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Solve any two. 20

1. Discuss the conjugation reaction for Glucuronic acid & Glycine from phase — II Drug metabolism reaction. Why cytochrome P — 450 called cytochrome P — 450?
2. Define & classify Antipsychotic agent & explain any one drug from each class. Add a note on SAR of Phenothiazine.
3. Define & classify sedative & Hypnotics drug write in detail about SAR of Benzodiazepines.

Solve any seven. 35

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1. Write a note on partition coefficient & Bioisosterism.
2. Explain SAR of sympathomimetic Agents.
3. Explain Biosynthesis & catabolism of Acetyl choline.
4. Discuss phase — II drug metabolism via Acetylation & methylation.
5. Add a note on Cholinesterase reactivator.

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6. Write a note on B blockers.
7. Explain any four drug from inhalation anesthetics.
8. Add a note on Narcotic Antagonist.
9. Explain Phase — I process of hydrolysis with eg.

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