Download SGBAU B-Pharma 2019 Summer 5th Sem Sem V Medicinal Chemistry I Question Paper

Pages: 1

Time : Three Hours

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Max. Marks : 60

Notes :

All questions carry equal marks.

Answer any five questions.

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Discuss the reaction, mechanism wherever necessary.

Use of pen Blue/Black ink/refill only for writing the answer book.

1. Define Drug metabolism. Explain in detail Glucuronic acid and sulfate conjugation reactions.

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2. What are prodrugs? Explain types of prodrugs with examples. Discuss various applications of prodrugs.

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3. Define and classify sympathomimetic agents with examples.

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4. Explain biosynthesis of adrenergic neurotransmitters.

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5. Define and classify anticholinergic agents with examples.

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6. Discuss SAR of anticholinergic agents.

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7. What are cholinergic agents? Explain SAR of Acetylcholine. Write a note on Reversible cholinesterase inhibitors.

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8. Enlist various physicochemical parameters which affect biological action of drugs. Explain any four of them.

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9. Write a note on any two.

   1. P-adrenergic receptor antagonists.
   2. Role of cytochrome P-450 monooxygenase in oxidative metabolism of drugs.
   3. Acetylation and methylation phase — II reactions.

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   4. Factors affecting Drug metabolism.