Jabalpur
MBBS Second Professional Examination
January-2025
Subject- Pharmacology
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Paper- II (new scheme)Time: 3:00 Hours
Maximum Marks :100
Instructions:
a) All questions are compulsory
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b) Draw diagrams wherever necessaryc) Answers of Questions and Sub-questions must be
written strictly according to serial order of question
paper.
d) MCQ has to be answered in theory answer book
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e) Please write MCQ answer neatly and in serial orderwith black or blue pen in brackets; for example: - 1.
(a) 2. (c)
f) MCQ has to be answered only once, any kind of
repetition or cutting or erasing or whitener will be
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considered as malpractice, such answers will not becounted in marks and action will be taken according to
UFM rules of university.
g) Subjective answer should be answered in up to 30
words per marks. For example, if a question having 2
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marks should answered in up to 60 marks.Q1. Total MCQs: 10
10 x 1 = 10
1. Which of the following drugs does not cause
hypoglycemia?
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(a) Acarbose(b) Insulin
(c) Glimepiride
(d) Nateglinide
2. Which drug is not included in Disease Modifying Anti-
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Rheumatoid Drugs (DMARDs)?(a) Chloroquine
(b) Vincristine
(c) Penicillamine
(d) Leflunomide
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3. The persistent suppression of bacterial growth thatoccurs after limited exposure to some antimicrobial drugs
is called:
(a) Time-dependent killing
(b) Post-Antibiotic effect
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(c) Concentration-dependent killing(d) Sequential Block
4. All of the following can be used to treat alcohol
dependence except:
(a) Naltrexone
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(b) Acamprosate(c) Flumazenil
(d) Disulfiram
5. Red man syndrome is caused by which drug?
(a) Linezolid
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(b) Clindamycin(c) Vancomycin
(d) Teicoplanin
6. Therapeutic indication of Donepezil:
(a) Parkinsonism
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(b) Alzheimer's Disease(c) Multiple sclerosis
(d) Myasthenia Gravis
7. Antihistamine used in motion sickness is:
(a) Cetirizine
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(b) Meclizine(c) Diphenhydramine
(d) Fexofenadine
8. Antipsychotic drug-induced parkinsonism is treated by:
(a) Centrally acting Anticholinergics
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(b) Levodopa(c) Selegiline
(d) Entacapone
9. In a patient on Isoniazid, which vitamin deficiency is
more likely to be seen?
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(a) Vitamin B9(b) Vitamin B12
(c) Vitamin B6
(d) Vitamin B3
10. Neuroleptics cause hyperprolactinemia by blocking
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the effect of the following on pituitary lactotropes:
(a) Dopamine
(b) Glycine
(c) Acetylcholine
(d) Serotonin
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Q2. Long Answer Questions2 x 20 = 40
a. A male aged 40 years, brought to hospital by his
relatives for having jerking of limbs and convulsions with
frothing from mouth. It was told that attack last for about
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2 minutes. Such attack also occurred in the past.I. Classify anti-epileptic drugs.
II. Write down mechanism of action of Sodium
Valproate.
III. Write down five non epileptic uses of anti-epileptic
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drugs.IV. Write treatment of status epilepticus
b. A 36 years old male was diagnosed as having severe
complicated falciparum malaria.
I. Write down the management of the above condition.
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II. Discuss in brief about therapeutic uses and adverseeffects of chloroquine.
III. Write a note on Artemisinin-based Combination
Therapy (ACT).
IV. What is the rationale of using primaquine in
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treatment of malaria?Q3. Brief Answer Questions
6 x 05 = 30
a. Write a note on SGLT-2 inhibitors.
b. Enumerate SSRIs Write basis of use of fluoxetine in
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depression.c. Why carbidopa is given with levodopa in parkinsonism
d. Write Antipseudomonal cephalosporins and their uses.
e. Write a short note on beta lactamase inhibitors.
f. Write the advantages of atypical antipsychotics over
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typical antipsychotics.Q4. Short Answer Questions
10 x 2 = 20
a. Write D2 Receptor partial agonists.
b. Write down important differences between
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propylthiouracil and carbimazole.c. Write down rationale of using Samidorphan with
Olanzapine in Schizophrenia.
d. Enumerate Adverse effects of aminoglycosides.
e. Explain Why sudden withdrawal of glucocorticoids
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after prolong therapy is Contraindicated.f. Explain why antitubercular drugs are given in
combination.
g. Write the mechanism of action of paracetamol as
antipyretic.
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h. Write note on Postcoital pills.i. Enumerate antiamoebic drugs. Write therapeutic uses
of metronidazole.
j. Two antiretroviral drugs use to prevent mother to child
transmissions.
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