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2106000102020102
Examination February-March 2024
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SECOND MBBS
PHARMACOLOGY ( PAPER - II ) - LEVEL 2
[Time: Three Hours] [Max. Marks: 100]
Instructions:
- Fill up strictly the following details on your answer book
- Name of the Examination: SECOND MBBS
- Name of the Subject: PHARMACOLOGY (PAPER - II) - LEVEL 2
- Subject Code No: 2106000102020102
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- Sketch neat and labelled diagram wherever necessary.
- Figures to the right indicate full marks of the question.
- All questions are compulsory.
- Answer should be precise and to the point.
- Give examples and figures if needed.
- First 20 mins have been allotted to solve multiple-choice questions.
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Seat No:
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Student's Signature
SECTION - I
Q.1 Multiple choice questions 1*20=20
- Each question carries one mark and there is no negative marking.
- Mechanism of action of digoxin is:
- Na+ K+ ATPase pump inhibition
- Na+H+ ATPase pump inhibition
- H+K+ ATPase pump inhibition
- Na+ Cl- ATPase pump inhibition
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- Which of the following antihypertensive is NOT used in pregnancy?
- Methyldopa
- Nifedipine
- Labetalol
- Enalapril
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- Which of the following is a class III antiarrhythmic drug?
- Phenytoin
- Pindolol
- Amiodarone
- Propafenone
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- Which of the following drug causes highest increases in serum High density lipoprotein (HDL)?
- Lovastatin
- Gemfibrozil
- Niacin
- Colestipol
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- Which of the following drug is preferentially a venodilator?
- Hydralazine
- Minoxidil
- Nifedipine
- Nitroprusside
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- Captopril causes all of the following adverse reactions EXCEPT
- Dry cough
- Hypokalemia
- Angioedema
- Dysguesia
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- All of the following antiplatelet drugs are GpIIb/IIIa antagonist EXCEPT:
- Prasugrel
- Abciximab
- Tirofiban
- Eptifibatide
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- Filgrastim is used in treatment of:
- Anemia
- Neutropenia
- Thrombocytopenia
- Polycythemia
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- Which of the following antithyroid drug is relatively safer in first trimester of pregnancy?
- Methimazole
- Propylthiouracil
- Amiodarone
- Carbimazole
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- Drug used in induction of ovulation is:
- Clofibrate
- Clomiphene
- Clozapine
- Clevidipine
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- Corticosteroids are contraindicated in all of the following EXCEPT:
- Congestive heart failure
- Ileocecal tuberculosis
- Bronchial asthma
- Peptic ulcer
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- Most common toxicity of bisphosphonates used in therapy of osteoporosis is:
- Esophageal irritation
- Osteonecrosis of jaw
- Chalkstick fracture of femur
- Osteomalacia
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- Which of the following is adverse effect of Cyclophosphamide?
- Cardiomyopathy
- Neuropathy
- Convulsion
- Hemorrhagic cystitis
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- Cyclosporine inhibits proliferation of which of the following cells:
- T Cells
- B cells
- Both T cells & B cells
- NK cells
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- The persistent suppression of bacterial growth after limited exposure to some antimicrobial drug is called:
- Time dependent killing
- Concentration dependent killing
- Post-antibiotic effect
- Quorum sensing
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- Aminoglycosides can cause which of the following toxicity?
- Ototoxicity
- Nephrotoxicity
- Neuromuscular Junction Blockade
- All of the above
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- Cilastatin is given as fixed dose combination (FDC) with:
- Clavulanic acid
- Amoxycillin
- Piperacillin
- Imipenem
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- Which of the following antitubercular drug act by inhibiting mycobacterial ATP synthase?
- Linezolid
- Levofloxacin
- Ethambutol
- Bedaquiline
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- Which of the following is not an indication of Metronidazole?
- Neurocysticercosis
- Pseudomembranous colitis
- Giardiasis
- Amoebiasis
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- Ondansetron act as an antiemetic by its which of the following action?
- Substance P antagonism
- D2 receptor antagonism
- 5-HT3 receptor antagonism
- Cannabinoid (CB1) receptor antagonism
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Q.2 Answer in short [any five]: 3*5=15
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- Enumerate drugs used in pharmacotherapy of peptic ulcer. Describe mechanism of action of proton pump inhibitors (PPIs).
- What is antimicrobial drug resistance? Describe mechanisms underlying antimicrobial drug resistance.
- Elaborate two prolactin inhibitors giving their uses and adverse effects.
- Write the mechanism of actions and adverse reactions of tetracycline.
- Enlist drugs used in osteoporosis. Write mechanism of action and two adverse reactions of bisphosphonates.
- What is informed consent? Explain its importance in clinical practice with an example.
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Q.3 Write answers in details [any three]: 5*3=15
- Discuss role of nitrates in angina pectoris.
- Describe the mechanism of action and therapeutic uses of ACE inhibitors.
- Enumerate oral iron preparation. Describe adverse effects and drug interactions of oral iron therapy.
- Pharmaco-therapy for urinary tract infection (UTI).
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Q.4 Answer the following questions based on the given case scenario: 10*1=10
A 35-year-old female patient had recurrent episodes of nose bleed accompanied by severe headache since last few days. On examination his blood pressure and pulse were 170/90 mm of Hg and 100/minute, respectively. The diagnosis is essential hypertension.
- Write drug therapy for managing this patient. 4
- Describe the mechanism of action and two adverse drug reactions to chosen drugs. 4
- Describe drugs used for treatment of hypertension in pregnancy? 2
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SECTION-II
Q.5 Write answers in short [any five]: 3*5=15
- Describe advantages of Low molecular weight heparin (LMWH) over unfractionated heparin (UFH).
- Describe the rationale of 'Boosted PI regimen' in pharmacotherapy of HIV.
- Write a short note on low dose aspirin.
- What is counterirritation? Describe various counterirritants used topically for relieving muscular pain.
- Write rationale of combining aluminium hydroxide and magnesium hydroxide as antacids.
- Describe mechanism of action of penicillin in treatment of gram-positive bacterial infection. Enumerate its clinically important adverse reactions.
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Q.6 Write answers in details [any three]: 5*3=15
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- Write a short note on thiazides.
- Outline pharmacotherapy of hyperthyroidism.
- Describe adverse drug reactions of corticosteroids.
- Mention mechanism of action and uses of fluroquinolones.
Q.7 Answer the following questions based on the given case scenario: 10*1=10
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A 21-year-old lady from Orrisa presents in clinic with a history of fever, anorexia and weakness since last two days. Fever is intermittent in nature accompanied by chills & rigors. Blood smear examination showed P. falciparum. The diagnosis is P. falciparum malaria.
- Mention suitable drug therapy for this patient. 3
- Explain the rationale behind artemisinin-based combination therapy (ACT). 4
- Enumerate two drugs used for chemoprophylaxis of malaria along with their adverse reactions. 3
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This download link is referred from the post: VNSGU MBBS Last 15 Years 2010-2025 Previous Question Papers (Veer Narmad South Gujarat University)
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