Download MBBS KUHS 1st Year 2022 Feb 2019 Scheme 116001 Biochemistry Paper II Question Paper

Download MBBS (Bachelor of Medicine, Bachelor of Surgery) KUHS (Kerala University of Health Science) 1st Year (First Year) 2022 Feb 2019 Scheme 116001 Biochemistry Paper II Previous Question Paper


2019 Scheme

Q.P. Code: 116001

Reg. no.: .....................

First Professional MBBS Degree Regular/Supplementary Examinations

February 2022

Biochemistry - Paper II

Time: 3 Hours

Total Marks: 100

Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers ?

Indicate the question number correctly for the answer in the margin space

Answer all parts of a single question together ? Leave sufficient space between answers

Draw table/diagrams/flow charts wherever necessary



Long Essays

(2x15=30)

1. A 70-year-old male presented to his family physician with yellow discoloration of sclera

associated with epigastric pain and weight loss. Urine had become darker in color and
his stools pale. A CT scan of the abdomen revealed a tumor in the pancreas.
Investigations: Total Bilibrubin ? 4.2mg/dl; Direct Bilirubin ? 3.8mg/dl; ALP ? 510U/L;
AST ? 80U/L; ALT -76U/L. Answer the following using the above data:

What is the probable diagnosis



Define and classify Jaundice



Which enzyme is specific for this type of jaundice and why



Explain the urinary findings



Why urine is dark in color and stools pale



Enumerate the causes of jaundice



List the laboratory investigations used to differentiate between the types of

jaundice.

(1+2+2+2+2+3+3)

2. Describe the process of transcription by providing the details on the following

Requisites

(1)

Promoters

(1)

Pre ? initiation complex

(2)

Initiation, Elongation and termination

(2+2+2)

Inhibitors

(2)

Post ? transcriptional modifications

(3)

Short essays

(5x8=40)

3. What is the normal reference range for serum calcium. How is it regulated. (1+1+3+3)
4. Define metabolic alkalosis. What are the characteristic features and causes of

metabolic alkalosis. Mention the compensatory mechanisms.

(1+3+2+2)

5. Describe the various stages of replication and add a note on DNA repair mechanism



(4+4)

6. Primary and secondary immune response

(4+4)

7. What are the sources for purine ring. Enumerate the reactions in denovo synthesis of

purine nucleotide. Add a note on its regulation.

(2+4+2)





(PTO)





Short answers

(5x4=20)

8. Collagen
9. Antioxidants
10. Give two examples for Phase II detoxification reaction.
11. C peptide
12. Structure of tRNA and its function





Give Precise Answers

(10x1=10)

13. Reference level of S. creatinine and blood urea.
14. Mention any two applications of Electrophoresis
15. Two tumour suppressor genes.
16. Mention any two post translational modifications
17. Name any two Iron containing enzymes
18. Give the principle of RIA

19. Give the normal albumin : globulin ratio

20. Wobble effect

21. Two enzymes as tumor markers and their clinical relavance

22. Give the names of compounds used for estimating clearance



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This post was last modified on 11 April 2022