Download MBBS (Bachelor of Medicine, Bachelor of Surgery) KUHS (Kerala University of Health Science) 1st Year (First Year) 2022 Feb 2019 Scheme 116001 Biochemistry Paper II Previous Question Paper
2019 Scheme
Q.P. Code: 116001
Reg. no.: .....................
First Professional MBBS Degree Regular/Supplementary Examinations
February 2022
Biochemistry - Paper II
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers ?
Indicate the question number correctly for the answer in the margin space
Answer all parts of a single question together ? Leave sufficient space between answers
Draw table/diagrams/flow charts wherever necessary
Long Essays
(2x15=30)
1. A 70-year-old male presented to his family physician with yellow discoloration of sclera
associated with epigastric pain and weight loss. Urine had become darker in color and
his stools pale. A CT scan of the abdomen revealed a tumor in the pancreas.
Investigations: Total Bilibrubin ? 4.2mg/dl; Direct Bilirubin ? 3.8mg/dl; ALP ? 510U/L;
AST ? 80U/L; ALT -76U/L. Answer the following using the above data:
What is the probable diagnosis
Define and classify Jaundice
Which enzyme is specific for this type of jaundice and why
Explain the urinary findings
Why urine is dark in color and stools pale
Enumerate the causes of jaundice
List the laboratory investigations used to differentiate between the types of
jaundice.
(1+2+2+2+2+3+3)
2. Describe the process of transcription by providing the details on the following
Requisites
(1)
Promoters
(1)
Pre ? initiation complex
(2)
Initiation, Elongation and termination
(2+2+2)
Inhibitors
(2)
Post ? transcriptional modifications
(3)
Short essays
(5x8=40)
3. What is the normal reference range for serum calcium. How is it regulated. (1+1+3+3)
4. Define metabolic alkalosis. What are the characteristic features and causes of
metabolic alkalosis. Mention the compensatory mechanisms.
(1+3+2+2)
5. Describe the various stages of replication and add a note on DNA repair mechanism
(4+4)
6. Primary and secondary immune response
(4+4)
7. What are the sources for purine ring. Enumerate the reactions in denovo synthesis of
purine nucleotide. Add a note on its regulation.
(2+4+2)
(PTO)
Short answers
(5x4=20)
8. Collagen
9. Antioxidants
10. Give two examples for Phase II detoxification reaction.
11. C peptide
12. Structure of tRNA and its function
Give Precise Answers
(10x1=10)
13. Reference level of S. creatinine and blood urea.
14. Mention any two applications of Electrophoresis
15. Two tumour suppressor genes.
16. Mention any two post translational modifications
17. Name any two Iron containing enzymes
18. Give the principle of RIA
19. Give the normal albumin : globulin ratio
20. Wobble effect
21. Two enzymes as tumor markers and their clinical relavance
22. Give the names of compounds used for estimating clearance
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This post was last modified on 11 April 2022