Q.P. Code: 116001
2019 Scheme
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Reg. no.: ........................
First Professional MBBS Degree Regular/Supplementary Examinations February 2022
Biochemistry - Paper II
Time: 3 Hours
Total Marks: 100
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- Answer all questions to the point neatly and legibly.
- Indicate the question number correctly for the answer in the margin space
- Answer all parts of a single question together.
- Draw table/diagrams/flow charts wherever necessary
Long Essays (2x15=30)
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A 70-year-old male presented to his family physician with yellow discoloration of sclera associated with epigastric pain and weight loss. Urine had become darker in color and his stools pale. A CT scan of the abdomen revealed a tumor in the pancreas. Investigations: Total Bilirubin 4.2mg/dl; Direct Bilirubin - 3.8mg/dl; ALP-510U/L; AST-80U/L; ALT-76U/L. Answer the following using the above data:
- What is the probable diagnosis
- Define and classify Jaundice
- Which enzyme is specific for this type of jaundice and why
- Explain the urinary findings
- Why urine is dark in color and stools pale
- Enumerate the causes of jaundice
- List the laboratory investigations used to differentiate between the types of jaundice. (1+2+2+2+2+3+3)
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Describe the process of transcription by providing the details on the following
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- Requisites (1)
- Promoters (1)
- Pre - initiation complex (2)
- Initiation, Elongation and termination (2+2+2)
- Inhibitors (2)
- Post - transcriptional modifications (3)
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Short essays (5x8=40)
- What is the normal reference range for serum calcium. How is it regulated. (1+1+3+3)
- Define metabolic alkalosis. What are the characteristic features and causes of metabolic alkalosis. Mention the compensatory mechanisms. (1+3+2+2)
- Describe the various stages of replication and add a note on DNA repair mechanism (4+4)
- Primary and secondary immune response (4+4)
- What are the sources for purine ring. Enumerate the reactions in denovo synthesis of purine nucleotide. Add a note on its regulation. (2+4+2)
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(PTO)
Short answers (5x4=20)
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- Collagen
- Antioxidants
- Give two examples for Phase II detoxification reaction.
- C peptide
- Structure of tRNA and its function
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Give Precise Answers (10x1=10)
- Reference level of S. creatinine and blood urea.
- Mention any two applications of Electrophoresis
- Two tumour suppressor genes.
- Mention any two post translational modifications
- Name any two Iron containing enzymes
- Give the principle of RIA
- Give the normal albumin: globulin ratio
- Wobble effect
- Two enzymes as tumor markers and their clinical relevance
- Give the names of compounds used for estimating clearance
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